Retraction

Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine

Paper Information

Record ID:

28136

Author(s):

Teng Zeng
William A Mitch

Journal:

Carcinogenesis ( Oxford Academic )

Publication Date:

March 18, 2016

Retraction Date:

May 04, 2021 (4.5 years years ago)

Subjects:

Broad Categories:
Medicine Toxicology

Specific Fields:
Toxicology Medicine - Urology/Nephrology

Institutions:

Department of Civil and Environmental Engineering, Syracuse University, 151 Link Hall, Syracuse, NY 13244, USA
Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA 94305, USA
National Science Foundation Engineering Research Center for Re-Inventing the Nation’s Urban Water Infrastructure (ReNUWIt), 473 Via Ortega, Stanford, CA 94305, USA

Country:

🇺🇸 United States

Article Type:

Clinical Study

Publisher:

Oxford Academic

Open Access:

Yes

DOI:

10.1093/carcin/bgw034

PubMed ID:

26992900

Retraction PubMed ID:

33942056

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction

Retraction Notice:

10.1093/carcin/bgab029

Citations (46)

46

Total Citations

20

Post-Retraction
(43.5%)

26

Pre-Retraction

0

Same Day

Post-Retraction Citation Analysis

3 Within 30 days

14 Within 1 year

1 After 2+ years

853 Days since retraction (latest)

Investigating the possibility of N-Nitrosodimethylamine (NDMA) in famotidine containing products

A Safdari, Farnaz Monajjemzadeh, Samin Hamidi

Journal of Drug Delivery Science and Technology

Published: Sep 2023
2 citations

853 days after retraction

A Bioanalytical Method for Quantification of N-nitrosodimethylamine (NDMA) in Human Plasma and Urine with Different Meals and following Administration of Ranitidine

Ryan De Palma, Vikram Patel, Jeffry Florian et al. (8 authors)

Journal of Pharmaceutical Sciences Open Access

Published: Feb 2023
7 citations

638 days after retraction

Orthogonal Chemical Reporter Strategy Enables Sensitive and Specific SERS Detection of Hydrazine Derivatives

Anwei Zhou, Xiaofeng Chen, Chaowei Li et al. (11 authors)

ACS Applied Materials & Interfaces

Published: Dec 2022
9 citations

604 days after retraction

Association between ranitidine use with potential NDMA impurities and risk of cancer in Korea

Kyung-In Joung, Jung Eun Hwang, In‐Sun Oh et al. (5 authors)

Scientific Reports Open Access

Published: Dec 2022
5 citations

602 days after retraction

An update on the current status and prospects of nitrosation pathways and possible root causes of nitrosamine formation in various pharmaceuticals

Wisut Wichitnithad, Siriwan Nantaphol, Kachathong Noppakhunsomboon et al. (4 authors)

Saudi Pharmaceutical Journal Open Access

Published: Dec 2022
44 citations

599 days after retraction

Nitrosamines in medicinal products

Katarzyna Dominiak, Marta Lewandowska, Katarzyna Dettlaff

Farmacja Polska Open Access

Published: May 2022

391 days after retraction

N-Nitrosodimethylamine (NDMA) and Some Prescribed Medicines

Chidiebere V. Ugwueze, Chidiebele M. Ezeude, Chinweuba M. Abonyi et al. (6 authors)

International Journal of Medicine and Health Development Open Access

Published: Mar 2022

303 days after retraction

A Full Evaporation Static Headspace Gas Chromatography Method with Nitrogen Phosphorous Detection for Ultrasensitive Analysis of Semi-volatile Nitrosamines in Pharmaceutical Products

Jinjian Zheng, Christine L. Kirkpatrick, Daniel Lee et al. (12 authors)

The AAPS Journal Open Access

Published: Jan 2022
23 citations

242 days after retraction

Dysregulation of fatty acid metabolism associated with esophageal inflammation of ICR mice induced by nitrosamines exposure

Hu Zhang, Chao Zhao, Qiwei Liu et al. (7 authors)

Environmental Pollution

Published: Dec 2021
17 citations

223 days after retraction

N-Nitrosodimethylamine-contaminated ranitidine and risk of cancer in South Korea: a nationwide cohort study

In Kyung Yoo, Dominic C. Marshall, Joo Young Cho et al. (5 authors)

Life Cycle Open Access

Published: Dec 2021
31 citations

215 days after retraction

Ranitidine and Risk of Bladder and Kidney Cancer: A Population-Based Cohort Study

Mette Nørgaard, Ina Trolle Andersen, Uffe Heide‐Jørgensen et al. (7 authors)

Cancer Epidemiology Biomarkers & Prevention Open Access

Published: Oct 2021
3 citations

163 days after retraction

Influencing Factors in N-nitrosodimethylamine (NDMA) Impurity Detection in Ranitidine and Possible Reactivity of other Histamine H2 Receptor Antagonists

Farnaz Monajjemzadeh, Thomas A. Robertson

Journal of Pharmaceutical Innovation

Published: Aug 2021
7 citations

101 days after retraction

Simultaneous Estimation of Six Nitrosamine Impurities in Valsartan Using Liquid Chromatographic Method

Kunjan B. Bodiwala, Bhoomi G. Panchal, S. S Savale et al. (7 authors)

Journal of AOAC International Open Access

Published: Jul 2021
13 citations

87 days after retraction

No association between chronic use of ranitidine, compared with omeprazole or famotidine, and gastrointestinal malignancies

Yeseong Kim, Jiasheng Wang, Fahmi Shibli et al. (6 authors)

Alimentary Pharmacology & Therapeutics

Published: Jul 2021
7 citations

69 days after retraction

Effect of Oral Ranitidine on Urinary Excretion ofN-Nitrosodimethylamine (NDMA)

Jeffry Florian, Murali K. Matta, Ryan DePalma et al. (18 authors)

JAMA Open Access

Published: Jun 2021
27 citations

55 days after retraction

Ranitidine and Risk ofN-Nitrosodimethylamine (NDMA) Formation

C Michael White, Adrían V. Hernández

JAMA

Published: Jun 2021
16 citations

55 days after retraction

In Vitro Analysis ofN-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

Zongming Gao, Michael Karfunkle, Wei Ye et al. (12 authors)

JAMA Network Open Open Access

Published: Jun 2021
16 citations

55 days after retraction

Exposure to Ranitidine and Risk of Bladder Cancer: A Nested Case-Control Study

Chris R. Cardwell, Ronald McDowell, Carmel Hughes et al. (5 authors)

The American Journal of Gastroenterology Open Access

Published: May 2021
12 citations

17 days after retraction

A Review on Carcinogenic Impurities Found in Marketed Drugs and Strategies for its Determination by Analytical Methods

Amitkumar J. Vyas, Jayshree P. Godhaniya, Ajay I. Patel et al. (7 authors)

Asian Journal of Pharmaceutical Analysis

Published: May 2021
24 citations

9 days after retraction

Nitrosamine Contamination in Pharmaceuticals: Threat, Impact, and Control

Bodin Tuesuwan, Vorasit Vongsutilers

Journal of Pharmaceutical Sciences

Published: May 2021
98 citations

7 days after retraction

Use of less-than-lifetime (LTL) durational limits for nitrosamines: Case study of N-Nitrosodiethylamine (NDEA)

Joel P. Bercu, Melisa Masuda-Herrera, George E. Johnson et al. (12 authors)

Regulatory Toxicology and Pharmacology Open Access

Published: Apr 2021
22 citations

21 days before retraction

Ranitidine’s N-nitrosodimethylamine Problem May be Tip of the Iceberg

C Michael White

JAMA Network Open Open Access

Published: Jan 2021
12 citations

95 days before retraction

Occurrence of N-nitrosamines and their precursors in the middle and lower reaches of Yangtze River water

Yingjie Chen, Wenwen Chen, Huanfang Huang et al. (8 authors)

Environmental Research

Published: Jan 2021
23 citations

97 days before retraction

Risk of Cancer Following the Use of N-Nitrosodimethylamine (NDMA) Contaminated Ranitidine Products: A Nationwide Cohort Study in South Korea

Hong Jin Yoon, Jie‐Hyun Kim, Gi Hyeon Seo et al. (4 authors)

Journal of Clinical Medicine Open Access

Published: Jan 2021
38 citations

119 days before retraction

Determination of N-nitrosodimethylamine in Ranitidine Dosage Forms by ESI-LC-MS/MS; Applications for Routine Laboratory Testing.

Jiao Liu, Zhi Zhao, Xiuling Yang et al. (7 authors)

PubMed

Published: Jan 2021
7 citations

123 days before retraction

Role of ranitidine in N-nitrosodimethylamine formation during chloramination of competing micropollutants

Mingizem Gashaw Seid, Jaeshik Chung, Jaewan Choe et al. (5 authors)

The Science of The Total Environment

Published: Nov 2020
8 citations

157 days before retraction

Impact of biological wastewater treatment on the reactivity of N-Nitrosodimethylamine precursors

Xiaolu Zhang, Daekyun Kim, David L. Freedman et al. (4 authors)

Water Research

Published: Aug 2020
8 citations

259 days before retraction

The U.S. medicine chest: Understanding the U.S. pharmaceutical supply chain and the role of the pharmacist

Ryan C. Costantino

Journal of the American Pharmacists Association Open Access

Published: Aug 2020
13 citations

259 days before retraction

Temperature-Dependent Formation of N-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets

Yasuhiro Abe, Eiichi Yamamoto, Hiroyuki Yoshida et al. (15 authors)

Chemical and Pharmaceutical Bulletin Open Access

Published: Aug 2020
36 citations

270 days before retraction

Pharmacists are key in interpreting clinical implications of N-nitrosodimethylamine contamination in medications

Andrea V Eads

Journal of the American Pharmacists Association

Published: Jul 2020
3 citations

277 days before retraction

Optimal management of severe symptomatic gastroesophageal reflux disease

Nicholas J. Talley, Mudar Zand Irani

Journal of Internal Medicine Open Access

Published: Jul 2020
41 citations

287 days before retraction

Analysis of Crowdsourced Metformin Tablets from Individuals Reveals Widespread Contamination with N-Nitrosodimethylamine (NDMA) and N,N-Dimethylformamide (DMF) in the United States

Qian Wu, Evgenia Kvitko, Amber Hudspeth et al. (7 authors)

medRxiv (Cold Spring Harbor Laboratory) Open Access

Published: May 2020
5 citations

343 days before retraction

Urinary exposure of N-nitrosamines and associated risk of esophageal cancer in a high incidence area in China

Chao Zhao, Jingjing Zhou, Yun Gu et al. (12 authors)

The Science of The Total Environment

Published: May 2020
41 citations

343 days before retraction

The Finding of N-Nitrosodimethylamine in Common Medicines

Richard H. Adamson, Bruce A. Chabner

The Oncologist Open Access

Published: Apr 2020
22 citations

391 days before retraction

Medicine and Media: The Ranitidine Debate

Jennifer A. Wagner, Jennifer M. Colombo

Clinical and Translational Science Open Access

Published: Feb 2020
26 citations

432 days before retraction

Source characterization and removal of N-nitrosamine precursors during activated sludge treatment

Xiaolu Zhang, Daekyun Kim, David L. Freedman et al. (4 authors)

Environmental Science Water Research & Technology

Published: Jan 2020
1 citation

489 days before retraction

Understanding and Preventing (N-Nitrosodimethylamine) NDMA Contamination of Medications

C Michael White

Annals of Pharmacotherapy Open Access

Published: Nov 2019
39 citations

525 days before retraction

Estimation of nizatidine gastric nitrosatability and product toxicity via an integrated approach combining HILIC, in silico toxicology, and molecular docking

Rania El‐Shaheny, Mohamed O. Radwan, Koji Yamada et al. (4 authors)

Journal of Food and Drug Analysis Open Access

Published: Aug 2019
11 citations

621 days before retraction

Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an, China

Chao Zhao, Qiang Lü, Yun Gu et al. (13 authors)

Chemosphere

Published: Jun 2019
69 citations

687 days before retraction

Application of biomarkers in the study of the health effects of disinfection by-products

Zhiyuan Chen, Lan Yang, Ziqi Li et al. (9 authors)

Current Opinion in Environmental Science & Health

Published: Jan 2019
7 citations

836 days before retraction

Comparing industrial and domestic discharges as sources of N-nitrosamines and their chloramine or ozone-reactive precursors

Yi-Hsueh Chuang, Farzaneh Shabani, J. A. Muñoz et al. (6 authors)

Environmental Science Water Research & Technology

Published: Jan 2019
16 citations

854 days before retraction

Critical review of major sources of human exposure to N-nitrosamines

Adam J. Gushgari, Rolf U. Halden

Chemosphere

Published: Jul 2018
127 citations

1019 days before retraction

Reduction of N-nitrosodimethylamine formation from ranitidine by ozonation preceding chloramination: influencing factors and mechanisms

Rusen Zou, Xiaobin Liao, Lei Zhao et al. (4 authors)

Environmental Science and Pollution Research

Published: Feb 2018
29 citations

1161 days before retraction

Prevention of bladder cancer incidence and recurrence

Christian D. Fankhauser, Hugh Mostafid

Current Opinion in Urology Open Access

Published: Oct 2017
53 citations

1309 days before retraction

Nitric Oxide Synthase and Nitric Oxide Involvement in Different Toxicities

Emine Atakişi, Oğuz MERHAN

InTech eBooks Open Access

Published: May 2017
12 citations

1448 days before retraction

Total organic halogen (TOX) in human urine: A halogen-specific method for human exposure studies

Susana Y. Kimura, Weiwei Zheng, Taylor N. Hipp et al. (5 authors)

Journal of Environmental Sciences

Published: Apr 2017
43 citations

1475 days before retraction

Quick Stats

Total Citations: 46

Years Since Retraction: 4.5 years

Open Access: Yes

Last Checked: Jul 24, 2025

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Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine

Paper Information

Institutions:

Country:

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction Notice:

Citations (46)

46

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26

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