Retraction

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease

Paper Information

Record ID:

30094

Author(s):

Antonella Caccamo
Ramona Belfiore
Salvatore Oddo

Journal:

Neurobiology of Aging ( Elsevier )

Publication Date:

April 05, 2018

Retraction Date:

June 20, 2021 (4.4 years years ago)

Subjects:

Broad Categories:
Neuroscience Biology Genetics

Specific Fields:
Biology - Cellular Genetics Neuroscience

Institutions:

The Arizona State University-Banner, Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
School of Life Sciences, Arizona State University, Tempe, AZ, USA

Country:

🇺🇸 United States

Article Type:

Research Article

Publisher:

Elsevier

Open Access:

Yes

DOI:

10.1016/j.neurobiolaging.2018.03.032

PubMed ID:

29729422

Retraction PubMed ID:

34162481

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction

Retraction Notice:

10.1016/j.neurobiolaging.2021.04.004

Citations (28)

28

Total Citations

6

Post-Retraction
(21.4%)

22

Pre-Retraction

0

Same Day

Post-Retraction Citation Analysis

1 Within 30 days

3 Within 1 year

2 After 2+ years

996 Days since retraction (latest)

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Current Nutraceuticals Open Access

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Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits

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Cells Open Access

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Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer’s Disease Induced by Aluminum

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Neurotoxicity Research

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Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles

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Alzheimer s & Dementia Open Access

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26 citations

156 days after retraction

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Henry Querfurth, Hankyu Lee

Molecular Neurodegeneration Open Access

Published: Jul 2021
201 citations

12 days after retraction

mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder

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Free Radical Biology and Medicine Open Access

Published: Apr 2021
97 citations

51 days before retraction

Regulation and metabolic functions of mTORC1 and mTORC2

Angelia Szwed, Eugene Kim, Estela Jacinto

Physiological Reviews Open Access

Published: Feb 2021
517 citations

122 days before retraction

Alzheimer’s Disease and Protein Kinases

Ayşe Başak Engin, Atilla Engin

Advances in experimental medicine and biology

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30 citations

170 days before retraction

Interaction of human IAPP and Aβ1-42 aggravated the AD-related pathology and impaired the cognition in mice

Haichao Chen, Jia‐Xin Cao, Yiting Cai et al. (9 authors)

Experimental Neurology

Published: Sep 2020
7 citations

263 days before retraction

Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

Fang Luo, Aaron F. Sandhu, Wiramon Rungratanawanich et al. (8 authors)

International Journal of Molecular Sciences Open Access

Published: Sep 2020
135 citations

265 days before retraction

Astaxanthin Improved the Cognitive Deficits in APP/PS1 Transgenic Mice Via Selective Activation of mTOR

Cuiqin Huang, Caiyan Wen, Mei Yang et al. (10 authors)

Journal of Neuroimmune Pharmacology

Published: Sep 2020
30 citations

275 days before retraction

A Comprehensive Review of Alzheimer’s Association with Related Proteins: Pathological Role and Therapeutic Significance

Deepak Kumar, Aditi Sharma, Lalit Sharma

Current Neuropharmacology Open Access

Published: Mar 2020
26 citations

461 days before retraction

Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Artem P. Gureev, В. Н. Попов, Anatoly A. Starkov

Experimental Neurology Open Access

Published: Mar 2020
65 citations

467 days before retraction

Geniposide effectively reverses cognitive impairment and inhibits pathological cerebral damage by regulating the mTOR Signal pathway in APP∕PS1 mice

Zhihua Zhang, Wenping Gao, Xiaojian Wang et al. (6 authors)

Neuroscience Letters

Published: Jan 2020
14 citations

526 days before retraction

Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice

Rasika Vartak, Alexis Rodin, Salvatore Oddo

Neurobiology of Aging

Published: Sep 2019
25 citations

656 days before retraction

Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Jessica L. Hoffman, Sara Faccidomo, Michelle Kim et al. (9 authors)

bioRxiv (Cold Spring Harbor Laboratory) Open Access

Published: Aug 2019
7 citations

684 days before retraction

Ketamine: A Neglected Therapy for Alzheimer Disease

Neil R. Smalheiser

Frontiers in Aging Neuroscience Open Access

Published: Jul 2019
23 citations

697 days before retraction

The db mutation improves memory in younger mice in a model of Alzheimer's disease

Le Zhang, Sun-Ok Fernandez-Kim, Tina L. Beckett et al. (9 authors)

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Published: Apr 2019
3 citations

786 days before retraction

Oxidative Stress, DNA Damage and Repair Pathways in Patients with Type 2 Diabetes Mellitus

Jéssica Ellen Barbosa de Freitas Lima, Danilo J. Xavier, Elza Tiemi Sakamoto‐Hojo

IntechOpen eBooks Open Access

Published: Apr 2019
1 citation

788 days before retraction

Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology

Men Su, Kambiz Naderi, Nathalie Samson et al. (9 authors)

Molecular Neurobiology Open Access

Published: Jan 2019
40 citations

877 days before retraction

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

Matt Kaeberlein, Verónica Galván

Science Translational Medicine Open Access

Published: Jan 2019
154 citations

879 days before retraction

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease

Jessica L. Hoffman, Sara Faccidomo, Michelle Kim et al. (9 authors)

International review of neurobiology Open Access

Published: Jan 2019
89 citations

901 days before retraction

Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line

Xiaogang Shen, JiaRui Zhang, Xiaolong Zhang et al. (6 authors)

Cellular and Molecular Neurobiology

Published: Dec 2018
15 citations

918 days before retraction

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice

Ramona Belfiore, Alexis Rodin, Eric Ferreira et al. (7 authors)

Aging Cell Open Access

Published: Nov 2018
244 citations

935 days before retraction

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto et al. (19 authors)

Neurobiology of Aging Open Access

Published: Nov 2018
28 citations

946 days before retraction

Are you <i> <scp>TORC</scp> ing tau </i> me? Amyloid‐β blocks the conversation between lysosomes and mitochondria

Juan Carlos Polanco, Jürgen Götz

The EMBO Journal Open Access

Published: Nov 2018
4 citations

961 days before retraction

Metabolic aspects of neuronal degeneration: From a NAD+ point of view

Yo Sasaki

Neuroscience Research Open Access

Published: Jul 2018
32 citations

1075 days before retraction

Quick Stats

Total Citations: 28

Years Since Retraction: 4.4 years

Open Access: Yes

Last Checked: Jul 24, 2025

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