Retraction

Melatonin promotes angiogenesis during repair of bone defects: a radiological and histomorphometric study in rabbit tibiae

Paper Information

Record ID:

34919

Author(s):

María Piedad Ramírez-Fernández
José Luis Calvo-Guirado
José Eduardo-Maté Sánchez de-Val
Rafael Arcesio Delgado-Ruiz
Bruno Negri
Guillermo Pardo-Zamora
David Peñarrocha
Cristina Barona
Jose Manuel Granero
Miguel Alcaraz-Baños

Journal:

Clinical Oral Investigations ( Springer )

Publication Date:

February 11, 2012

Retraction Date:

January 03, 2022 (3.9 years years ago)

Subjects:

Broad Categories:
Medicine Biology Biochemistry Toxicology

Specific Fields:
Biochemistry Biology - Cellular Toxicology Medicine - Orthopedics

Institutions:

Country:

🇪🇸 Spain

Article Type:

Research Article

Publisher:

Springer

Open Access:

Yes

DOI:

10.1007/s00784-012-0684-6

PubMed ID:

22323056

Retraction PubMed ID:

34978599

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction

Retraction Notice:

10.1007/s00784-021-04350-4

Citations (60)

60

Total Citations

9

Post-Retraction
(15.0%)

51

Pre-Retraction

0

Same Day

Post-Retraction Citation Analysis

0 Within 30 days

6 Within 1 year

2 After 2+ years

1109 Days since retraction (latest)

The Effect of Local Melatonin Application on Bone Fracture Healing in Rat Tibias

Murat Tanrısever, Bahar Tekin, Ümit Koray Can et al. (8 authors)

Medicina Open Access

Published: Jan 2025

1109 days after retraction

Significant Interaction between Melatonin and Titanium Bone Implants: Available Evidence and Future Research Directions

Azam Hosseinzadeh, Abolfazl Bagherifard, Mohammad Sheibani et al. (6 authors)

Current Pharmaceutical Biotechnology

Published: Jun 2024
1 citation

905 days after retraction

Histopathological evaluation of the effect of melatonin gel on bone regeneration in rat model

Leila Golpasandhagh, Neda Samie, Soroush Sabiza et al. (4 authors)

Journal of Indian Society of Periodontology Open Access

Published: Jul 2023
3 citations

544 days after retraction

Does Melatonin Associated with Nanostructured Calcium Phosphate Improve Alveolar Bone Repair?

Camila Diuana de Almeida, Suelen Cristina Sartoretto, Adriana Terezinha Neves Novellino Alves et al. (10 authors)

Medicina Open Access

Published: Nov 2022
10 citations

325 days after retraction

Histological and Immunohistochemical Analysis of the Effects of Topical Melatonin Treatment Associated with Collagen Sponge and rhBMP-2 Protein on Bone Remodeling

Letícia Ferreira Montarele, Dimítrius Leonardo Pitol, Bruno Fiorelini Pereira et al. (6 authors)

Biomolecules Open Access

Published: Nov 2022
6 citations

324 days after retraction

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Ming Yi, Ying Yin, Jiwei Sun et al. (6 authors)

Frontiers in Molecular Biosciences Open Access

Published: Sep 2022
9 citations

255 days after retraction

The Effect of Melatonin on Nasal Septal Wound Healing in an Experimental Animal Model

Doğan Çakan, Semih Uşaklıoğlu

Facial Plastic Surgery

Published: Jul 2022
3 citations

204 days after retraction

Regeneration of <scp>critical‐sized</scp> grade <scp>II</scp> furcation using a novel injectable <scp>melatonin‐loaded</scp> scaffold

Mohamed Roshdy Abdelrasoul, Ahmed Abd El‐Fattah, Gehan Kotry et al. (7 authors)

Oral Diseases

Published: Jul 2022
13 citations

193 days after retraction

Melatonin Accelerates Osteoporotic Bone Defect Repair by Promoting Osteogenesis–Angiogenesis Coupling

Sheng Zheng, Chunhao Zhou, Han Yang et al. (7 authors)

Frontiers in Endocrinology Open Access

Published: Feb 2022
48 citations

50 days after retraction

Melatonin ameliorates aging-related impaired angiogenesis in gastric endothelial cells via local actions on mitochondria and VEGF-survivin signaling

Amrita Ahluwalia, Khushin Patel, Neil Hoa et al. (6 authors)

AJP Gastrointestinal and Liver Physiology

Published: Oct 2021
10 citations

75 days before retraction

Melatonin having Therapeutic Bone Regenerating Capacity in Biomaterials

Jinming Huang, Yi Li, Chengqi He

Current Pharmaceutical Biotechnology

Published: Jul 2021
5 citations

175 days before retraction

The influence of functional pinealectomy and exogenous melatonin application on healing of a burr hole in adult rat calvaria: a histological and immunohistochemical study

H. Kübra Başaloğlu, Mehmet Turgut, Cansın Şirin et al. (6 authors)

Folia Morphologica Open Access

Published: May 2021
4 citations

231 days before retraction

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Xiaofeng Lu, Shaoling Yu, Guangjin Chen et al. (7 authors)

International Journal of Molecular Medicine Open Access

Published: Mar 2021
76 citations

292 days before retraction

Role of Melatonin in Bone Remodeling around Titanium Dental Implants: Meta-Analysis

Nansi López-Valverde, Beatriz Pardal-Peláez, Antonio López‐Valverde et al. (4 authors)

Coatings Open Access

Published: Feb 2021
11 citations

312 days before retraction

Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease

Afshin Rahbarghazi, Marefat Siahkouhian, Reza Rahbarghazi‬ et al. (8 authors)

Journal of Inflammation Open Access

Published: Feb 2021
29 citations

335 days before retraction

The effect of melatonin on prevention of bisphosphonate-related osteonecrosis of the jaw: an animal study in rats

Afshin Yadegari, Atousa Aminzadeh, Samad Seyyedkhamesi et al. (4 authors)

Journal of the Korean Association of Oral and Maxillofacial Surgeons Open Access

Published: Aug 2020
10 citations

493 days before retraction

Effect of melatonin versus injectable platelet rich fibrin on critical wound healing in submandibular salivary glands of diabetic rats

Amira M. Elsherbini, Samah K. Ezzat

Journal of Oral Biology and Craniofacial Research Open Access

Published: Aug 2020
17 citations

495 days before retraction

Application of growth hormone to reduce osseointegration time in dental implants

Ana Rego, Jesus Af. Tresguerres, Jose M Tallon et al. (4 authors)

Journal of Dental Health Oral Disorders and Therapy Open Access

Published: Aug 2020
2 citations

497 days before retraction

Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats

Viviane Lopes Rocha Corrêa, Juliana Assis Martins, Tainara Ribeiro de Souza et al. (7 authors)

International Journal of Biological Macromolecules

Published: Aug 2020
90 citations

513 days before retraction

A possible use of melatonin in the dental field: Protein adsorption and in vitro cell response on coated titanium

Andreia Cerqueira, Francisco Romero‐Gavilán, Nuno Araújo‐Gomes et al. (11 authors)

Materials Science and Engineering C Open Access

Published: Jul 2020
25 citations

549 days before retraction

Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition

Kai Chen, Changci Tong, JingeYang et al. (15 authors)

Journal of Material Science and Technology

Published: Jun 2020
54 citations

562 days before retraction

RETRACTED: Experimental Study on the Influence of Apigenin K and Melatonin in Socket Preservation as Bone Stimulators: An Experimental Study in Beagle Dogs

José Luís Calvo‐Guirado, Manuel Fernández‐Domínguez, Juan Manuel Aragoneses et al. (10 authors)

Applied Sciences Open Access

Published: Apr 2020
4 citations

618 days before retraction

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Mohammad Mirza‐Aghazadeh‐Attari, Russel J. Reíter, Reza Rikhtegar et al. (8 authors)

IUBMB Life Open Access

Published: Apr 2020
20 citations

619 days before retraction

Rapamycin could increase the effects of melatonin against age-dependent bone loss

Zhou-Shan Tao, Hanli Lu, Nengfeng Ma et al. (7 authors)

Zeitschrift für Gerontologie und Geriatrie

Published: Nov 2019
17 citations

767 days before retraction

Melatonin improves the osseointegration of hydroxyapatite-coated titanium implants in senile female rats

Tao Sun, Jian Li, Hai-Lin Xing et al. (5 authors)

Zeitschrift für Gerontologie und Geriatrie

Published: Oct 2019
17 citations

801 days before retraction

Role of melatonin in controlling angiogenesis under physiological and pathological conditions

Qiang Ma, Russel J. Reíter, Yundai Chen

Angiogenesis

Published: Oct 2019
152 citations

802 days before retraction

Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury

Geir Bjørklund, Maryam Dadar, Jan Aaseth et al. (4 authors)

Current Medicinal Chemistry

Published: Jul 2019
11 citations

895 days before retraction

Hyaluronic Acid/Bone Substitute Complex Implanted on Chick Embryo Chorioallantoic Membrane Induces Osteoblastic Differentiation and Angiogenesis, but not Inflammation

Laura Cîrligeriu, Anca Maria Cîmpean, Horia Călniceanu et al. (7 authors)

International Journal of Molecular Sciences Open Access

Published: Dec 2018
17 citations

1111 days before retraction

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health

Chengliang Luo, Qiang Yang, Yuancai Liu et al. (19 authors)

Free Radical Biology and Medicine

Published: Oct 2018
65 citations

1180 days before retraction

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis

İzzet Acıkan, Mehmet Gül, Gökhan Artaş et al. (9 authors)

Brazilian Oral Research Open Access

Published: Sep 2018
16 citations

1200 days before retraction

Daily melatonin administration improves osseointegration in pinealectomized rats

Leticia Pitol‐Palin, Tárik Ocon Braga Polo, Fábio Roberto de Souza Batista et al. (10 authors)

Journal of Applied Oral Science Open Access

Published: Jul 2018
33 citations

1273 days before retraction

The multiple functions of melatonin in regenerative medicine

Maryam Majidinia, Russel J. Reíter, Seyed Kazem Shakouri et al. (10 authors)

Ageing Research Reviews

Published: Apr 2018
90 citations

1368 days before retraction

One-pot preparation of polymer microspheres with different porous structures to sequentially release bio-molecules for cutaneous regeneration

Pingyun Yuan, Xinyu Qiu, Ronghua Jin et al. (6 authors)

Biomaterials Science

Published: Jan 2018
22 citations

1463 days before retraction

Prophylactic supplement with melatonin successfully suppresses the pathogenesis of periodontitis through normalizing <scp>RANKL</scp>/<scp>OPG</scp> ratio and depressing the <scp>TLR</scp>4/MyD88 signaling pathway

Ting‐Yi Renn, Yung‐Kai Huang, Sheng‐Wei Feng et al. (10 authors)

Journal of Pineal Research

Published: Dec 2017
62 citations

1471 days before retraction

Efficacy of topical melatonin hormone on implant osseointegration

mohammad mohammad alsehimy, Ayman Al-Dharrab, Ahmad Jan

Egyptian Journal of Oral & Maxillofacial Surgery

Published: Oct 2017

1555 days before retraction

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

María Permuy, Mónica López‐Peña, Antonio González‐Cantalapiedra et al. (4 authors)

International Journal of Molecular Sciences Open Access

Published: Apr 2017
69 citations

1720 days before retraction

Purmorphamine increased adhesion, proliferation and expression of osteoblast phenotype markers of human dental pulp stem cells cultured on beta-tricalcium phosphate

Maryam Rezia Rad, Moein Khojaste, Mehrnoosh Hasan Shahriari et al. (5 authors)

Biomedicine & Pharmacotherapy

Published: Jun 2016
14 citations

2041 days before retraction

Retracted: Histologic evaluation of new bone in post‐extraction sockets induced by melatonin and apigenin: an experimental study in American fox hound dogs

José Luís Calvo‐Guirado, Patricia J. López‐López, Manuel Fernández Domínguez et al. (6 authors)

Clinical Oral Implants Research Open Access

Published: May 2016
7 citations

2056 days before retraction

Melatonin as a pro‐osteogenic agent in oral implantology: a systematic review of histomorphometric outcomes in animals and quality evaluation using <scp>ARRIVE</scp> guidelines

Himanshu Arora, Sašo Ivanovski

Journal of Periodontal Research

Published: Apr 2016
13 citations

2083 days before retraction

Investigational drugs for fracture healing: preclinical & clinical data

Michail E. Klontzas, Eustathios Kenanidis, Robert J MacFarlane et al. (8 authors)

Expert Opinion on Investigational Drugs

Published: Mar 2016
31 citations

2131 days before retraction

Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs

Oscar Salomó‐Coll, José‐Eduardo Maté‐Sánchez, Maria Piedad Ramírez Fernández et al. (6 authors)

Clinical Oral Implants Research

Published: Feb 2016
20 citations

2135 days before retraction

Melatonin in functionalized biomimetic constructs promotes rapid tissue regeneration in Wistar albino rats

Ragothaman Murali, P. Thanikaivelan, Cheirmadurai Kalirajan

Journal of Materials Chemistry B

Published: Jan 2016
19 citations

2194 days before retraction

Melatonin facilitates adipose‐derived mesenchymal stem cells to repair the murine infarcted heart<i>via</i>the SIRT1 signaling pathway

Dong Han, Wei Huang, Xiang Li et al. (12 authors)

Journal of Pineal Research

Published: Nov 2015
109 citations

2230 days before retraction

Multiple Integrated Complementary Healing Approaches: Energetics & Light for bone

Michael G. Gray, Brett R. Lackey, Evelyn F. Patrick et al. (5 authors)

Medical Hypotheses

Published: Nov 2015
5 citations

2232 days before retraction

Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces

H Shino, Akira Hasuike, Yoshinori Arai et al. (6 authors)

Medicina oral, patología oral y cirugía bucal Open Access

Published: Nov 2015
36 citations

2238 days before retraction

An insight into the scientific background and future perspectives for the potential uses of melatonin

Md Jamir Anwar, Bala Yauri Muhammad, Ahmed Abdul-Sabour Bader et al. (6 authors)

Egyptian Journal of Basic and Applied Sciences Open Access

Published: May 2015
26 citations

2411 days before retraction

Biomaterial-mediated strategies targeting vascularization for bone repair

José R. García, Andrés J. Garcı́a

Drug Delivery and Translational Research Open Access

Published: May 2015
84 citations

2414 days before retraction

Osseoinductive elements for promoting osseointegration around immediate implants: a pilot study in the foxhound dog

Oscar Salomó‐Coll, José Eduardo Maté Sánchez de Val, Maria Piedad Ramírez Fernández et al. (6 authors)

Clinical Oral Implants Research

Published: Apr 2015
22 citations

2468 days before retraction

Therapeutic Effects of Melatonin on Alveolar Bone Resorption After Experimental Periodontitis in Rats: A Biochemical and Immunohistochemical Study

Taner Arabacı, Eda Kermen, Seçkin Özkanlar et al. (8 authors)

Journal of Periodontology

Published: Mar 2015
79 citations

2474 days before retraction

Outcomes of Topical Applications of Melatonin in Implant Dentistry

Gerardo Gómez‐Moreno, Antonio Aguilar‐Salvatierra, Ana Boquete‐Castro et al. (8 authors)

Implant Dentistry Open Access

Published: Jan 2015
19 citations

2536 days before retraction

Quick Stats

Total Citations: 60

Years Since Retraction: 3.9 years

Open Access: Yes

Last Checked: Jul 24, 2025

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