Retraction
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2
Paper Information
Record ID:
38498
Author(s):
Journal:
Publication Date:
April 20, 2020
Retraction Date:
August 04, 2022
(3.3 years years ago)
Subjects:
Institutions:
- Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
- Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Elsevier - Cell Press
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (81)
81
Total Citations20
Post-Retraction(24.7%)
61
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
1
Within 30 days
13
Within 1 year
1
After 2+ years
757
Days since retraction (latest)
gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination
Yamei Han, Mingming Xiao, Shaorong Zhao et al. (6 authors)
iScience
Open Access
Published: Aug 2024
1 citation
1 citation
757 days after retraction
Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases
Jie Wen, Jingwei Zhang, Hao Zhang et al. (9 authors)
Journal of Translational Medicine
Open Access
Published: Apr 2024
39 citations
39 citations
634 days after retraction
Multimodal fused deep learning for drug property prediction: Integrating chemical language and molecular graph
Xiaohua Lu, Liangxu Xie, Lei Xu et al. (6 authors)
Computational and Structural Biotechnology Journal
Open Access
Published: Apr 2024
11 citations
11 citations
617 days after retraction
The oncogene MYBL2 promotes the malignant phenotype and suppresses apoptosis through hedgehog signaling pathway in clear cell renal cell carcinoma
Wenjie Yang, Hualin Chen, Lin Ma et al. (9 authors)
Heliyon
Open Access
Published: Mar 2024
3 citations
3 citations
575 days after retraction
A Protein Phosphatase 2A-Based Assay to Detect Okadaic Acids and Microcystins
Tsuyoshi Ikehara, Naomasa Oshiro
Journal of Marine Science and Engineering
Open Access
Published: Jan 2024
4 citations
4 citations
544 days after retraction
Altering phosphorylation in cancer through PP2A modifiers
Hannah Johnson, Satya Narayan, Arun Sharma
Cancer Cell International
Open Access
Published: Jan 2024
19 citations
19 citations
520 days after retraction
Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice
Xianming Zhou, Qian Xu, Wangzi Li et al. (7 authors)
Transplantation
Published: Oct 2023
1 citation
1 citation
438 days after retraction
Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death
Rita A. Avelar, Amy J. Armstrong, Gracie Carvette et al. (23 authors)
Molecular Cancer Therapeutics
Open Access
Published: Feb 2023
17 citations
17 citations
194 days after retraction
PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages
Winson S. Ho, Isha Mondal, Beisi Xu et al. (15 authors)
Journal of Clinical Investigation
Open Access
Published: Feb 2023
20 citations
20 citations
189 days after retraction
Transcription factor E2F8 is a therapeutic target in the basal-like subtype of breast cancer
Jing Zheng, Jingyi Huang, Jinquan Xia et al. (8 authors)
Frontiers in Oncology
Open Access
Published: Feb 2023
7 citations
7 citations
186 days after retraction
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
Brendan T. Finicle, Kazumi Eckenstein, Alexey S. Revenko et al. (11 authors)
Nucleic Acids Research
Open Access
Published: Feb 2023
18 citations
18 citations
182 days after retraction
Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation
Gaifen Li, Jia Liu, Mengyuan Guo et al. (8 authors)
Cell Death Discovery
Open Access
Published: Nov 2022
25 citations
25 citations
118 days after retraction
Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation
Xunming Ji, Gaifen Li, Jia Liu et al. (8 authors)
Research Square (Research Square)
Open Access
Published: Nov 2022
89 days after retraction
The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
Mingxing Teng, Damian W. Young, Zhi Tan
Journal of Medicinal Chemistry
Published: Oct 2022
4 citations
4 citations
77 days after retraction
Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation
Abhijit Deb Roy, Evan G. Gross, Gayatri S. Pillai et al. (6 authors)
The Journal of Cell Biology
Open Access
Published: Oct 2022
15 citations
15 citations
69 days after retraction
<scp>MYC</scp> and therapy resistance in cancer: risks and opportunities
Giulio Donati, Bruno Amati
Molecular Oncology
Open Access
Published: Oct 2022
60 citations
60 citations
67 days after retraction
Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity
Thomas Kokot, Maja Köhn
Journal of Cell Science
Open Access
Published: Oct 2022
25 citations
25 citations
58 days after retraction
Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen
Victor Clausse, Yuhong Fang, Dingyin Tao et al. (18 authors)
ACS Pharmacology & Translational Science
Open Access
Published: Sep 2022
8 citations
8 citations
55 days after retraction
Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML
Nam Nguyen, Roya Rafiee, Abderrahmane Tagmount et al. (17 authors)
Blood Advances
Open Access
Published: Sep 2022
13 citations
13 citations
43 days after retraction
Targets for Renal Carcinoma Growth Control Identified by Screening FOXD1 Cell Proliferation Pathways
Kyle Bond, Sunder Sims‐Lucas, Leif Oxburgh
Cancers
Open Access
Published: Aug 2022
4 citations
4 citations
12 days after retraction
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors
Jing Liu, Xufen Yu, He Chen et al. (8 authors)
Journal of the American Chemical Society
Open Access
Published: Jul 2022
42 citations
42 citations
30 days before retraction
Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061
Gianmatteo Vit, Joana Duro, Girish Rajendraprasad et al. (16 authors)
The EMBO Journal
Open Access
Published: Jun 2022
24 citations
24 citations
52 days before retraction
Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death
Rita A. Avelar, Amy J. Armstrong, Gracie Carvette et al. (22 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Jun 2022
53 days before retraction
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
Jie Pan, Lisha Zhou, Chenyang Zhang et al. (5 authors)
Signal Transduction and Targeted Therapy
Open Access
Published: Jun 2022
69 citations
69 citations
61 days before retraction
Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
Satya Narayan, Asif Raza, Iqbal Mahmud et al. (8 authors)
iScience
Open Access
Published: Jun 2022
7 citations
7 citations
62 days before retraction
Synergistic antitumor effects of compound-composed optimal formula from Aidi injection on hepatocellular carcinoma and colorectal cancer
Pei An, Lu Dong, Lijun Zhang et al. (14 authors)
Phytomedicine
Published: Jun 2022
19 citations
19 citations
63 days before retraction
Overexpression of the global regulator FnVeA upregulates antitumor substances in endophytic <i>Fusarium nematophilum</i>
Min Qin, Yongjie Li, Lu Cai et al. (6 authors)
Canadian Journal of Microbiology
Published: Jun 2022
2 citations
2 citations
64 days before retraction
Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models
Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi et al. (16 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: May 2022
2 citations
2 citations
65 days before retraction
Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells
Ganesh babu Manoharan, Sunday Okutachi, Daniel Abankwa
PLoS ONE
Open Access
Published: May 2022
13 citations
13 citations
70 days before retraction
Regulation of XPO5 phosphorylation by PP2A in hepatocellular carcinoma
Jiao Li, Jiankang Zhou, Xiaoyu Mu et al. (10 authors)
MedComm
Open Access
Published: Apr 2022
10 citations
10 citations
111 days before retraction
Pre-Clinical Study Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Neuroblastoma
Laura V. Bownes, Raoud Marayati, Colin H. Quinn et al. (13 authors)
Cancers
Open Access
Published: Apr 2022
13 citations
13 citations
113 days before retraction
PP2A and cancer epigenetics: a therapeutic opportunity waiting to happen
Samantha L. Tinsley, Brittany L. Allen-Petersen
NAR Cancer
Open Access
Published: Jan 2022
17 citations
17 citations
203 days before retraction
PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
Mohd Moin Khan, Ubaid Ullah Kalim, Meraj Hasan Khan et al. (4 authors)
Frontiers in Immunology
Open Access
Published: Jan 2022
20 citations
20 citations
211 days before retraction
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells
Qian Zeng, Fangfang Jin, Husun Qian et al. (10 authors)
Carcinogenesis
Open Access
Published: Dec 2021
11 citations
11 citations
237 days before retraction
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities
Nicola M. Sergienko, D. Donner, Lea M.D. Delbridge et al. (5 authors)
Cellular Signalling
Published: Dec 2021
11 citations
11 citations
237 days before retraction
PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia
Swagata Goswami, Rajeswaran Mani, Jessica Nunes et al. (29 authors)
Blood
Open Access
Published: Nov 2021
28 citations
28 citations
260 days before retraction
Relationship between osteoporosis and benign paroxysmal positional vertigo based on evidence-based medicine and bioinformatics
Tuanmao Guo, Yanli Xing, Hai-Yun Zhu et al. (6 authors)
Archives of Osteoporosis
Published: Nov 2021
3 citations
3 citations
262 days before retraction
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)
Po‐Han Chen, Zhenyi Hu, Elvira An et al. (9 authors)
ACS Chemical Biology
Open Access
Published: Nov 2021
92 citations
92 citations
262 days before retraction
A highly predictive autoantibody-based biomarker panel for prognosis in early-stage NSCLC with potential therapeutic implications
Akshay J. Patel, Ti-Myen Tan, Alex Richter et al. (6 authors)
British Journal of Cancer
Open Access
Published: Nov 2021
37 citations
37 citations
275 days before retraction
Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
Bruno Rizzuti, Wenjun Lan, Patricia Santofimia‐Castaño et al. (10 authors)
Biomolecules
Open Access
Published: Oct 2021
24 citations
24 citations
305 days before retraction
MYBL2 Gene Polymorphism Is Associated With Acute Lymphoblastic Leukemia Susceptibility in Children
Haixia Guo, Na Li, Yaping Sun et al. (7 authors)
Frontiers in Oncology
Open Access
Published: Sep 2021
4 citations
4 citations
330 days before retraction
Cellular feedback dynamics and multilevel regulation driven by the hippo pathway
Jiwon Park, Carsten Gram Hansen
Biochemical Society Transactions
Open Access
Published: Aug 2021
17 citations
17 citations
359 days before retraction
Cancer stem cell phosphatases
Majid Momeny, Tiina Arsiola, Jukka Westermarck
Biochemical Journal
Published: Jul 2021
3 citations
3 citations
372 days before retraction
Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
Satya Narayan, Asif Raza, Iqbal Mahmud et al. (8 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Jul 2021
377 days before retraction
Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia
Xueliang Gao, Shenghui Qin, Yongxia Wu et al. (14 authors)
Journal of Clinical Investigation
Open Access
Published: Jul 2021
39 citations
39 citations
387 days before retraction
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease
Iris Verbinnen, Pieter Vaneynde, Sara Reynhout et al. (7 authors)
Biochemical Society Transactions
Open Access
Published: Jul 2021
39 citations
39 citations
391 days before retraction
Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting
Gianmatteo Vit, Joana Duro, Girish Rajendraprasad et al. (14 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Jul 2021
3 citations
3 citations
391 days before retraction
PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition
Bob Meeusen, Emanuela Elsa Cortesi, Judit Domènech Omella et al. (6 authors)
Cancer Letters
Open Access
Published: Jun 2021
12 citations
12 citations
400 days before retraction
Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents
David L. Brautigan, Caroline Farrington, Goutham Narla
Clinical Science
Open Access
Published: Jun 2021
19 citations
19 citations
400 days before retraction
Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer
Qiuyue Zhang, Zhongjiao Fan, Lianshan Zhang et al. (5 authors)
Journal of Medicinal Chemistry
Published: Jun 2021
26 citations
26 citations
408 days before retraction
Quick Stats
Total Citations:
81
Years Since Retraction:
3.3 years
Open Access:
Yes
Last Checked:
Jul 24, 2025