Retraction
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease
Paper Information
Record ID:
39567
Author(s):
Journal:
Publication Date:
March 12, 2013
Retraction Date:
October 05, 2022
(3.1 years years ago)
Subjects:
Institutions:
- Center for Translational Medicine and Temple University School of Medicine, Philadelphia, PA, USA
- Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA
- Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA
- Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Springer - Nature Publishing Group
Open Access:
Yes
DOI:
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (55)
55
Total Citations1
Post-Retraction(1.8%)
54
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
1
Within 30 days
1
Within 1 year
0
After 2+ years
5
Days since retraction (latest)
Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans
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Published: Oct 2022
8 citations
8 citations
5 days after retraction
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness
Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali et al. (7 authors)
Frontiers in Immunology
Open Access
Published: Apr 2022
16 citations
16 citations
159 days before retraction
Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans
Fabrício A. Pamplona, Gabriela Vitória, Felipe C. Ribeiro et al. (22 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Nov 2021
2 citations
2 citations
326 days before retraction
Comparison of different extraction methods of Brazilian “pacová” (Renealmia petasites Gagnep.) oilseeds for the determination of lipid and terpene composition, antioxidant capacity, and inhibitory effect on neurodegenerative enzymes
Luana Cristina dos Santos, Gerardo Álvarez‐Rivera, José David Sánchez-Martínez et al. (9 authors)
Food Chemistry X
Open Access
Published: Oct 2021
3 citations
3 citations
351 days before retraction
Interrelationship between the 5-lipoxygenase pathway and microbial dysbiosis in the progression of Alzheimer's disease
Steven Mathis, Sobha R. Bodduluri, Bodduluri Haribabu
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Published: May 2021
5 citations
5 citations
494 days before retraction
5-Lipoxygenase as an emerging target against age-related brain disorders
Mengdie Yan, Siran Zhang, Cheng-Tan Li et al. (8 authors)
Ageing Research Reviews
Published: May 2021
22 citations
22 citations
513 days before retraction
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
Johanna Michael, Julia Zirknitzer, Michael S. Unger et al. (10 authors)
International Journal of Molecular Sciences
Open Access
Published: Mar 2021
29 citations
29 citations
575 days before retraction
Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
J. Michael, Michael S. Unger, Rodolphe Poupardin et al. (7 authors)
Acta Neuropathologica Communications
Open Access
Published: Aug 2020
34 citations
34 citations
788 days before retraction
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation
Zonglin He, Tao Di, Jiaming Xiong et al. (9 authors)
Neurochemical Research
Published: Jul 2020
17 citations
17 citations
812 days before retraction
Molecular Pathogenesis and Interventional Strategies for Alzheimer’s Disease: Promises and Pitfalls
Shashikala Bhute, Deepaneeta Sarmah, Aishika Datta et al. (10 authors)
ACS Pharmacology & Translational Science
Open Access
Published: Mar 2020
27 citations
27 citations
923 days before retraction
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease
Fang Chen, Arijit Ghosh, Jingran Lin et al. (9 authors)
Brain Behavior and Immunity
Published: Mar 2020
62 citations
62 citations
923 days before retraction
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
Julia Marschallinger, Barbara Altendorfer, Edward Rockenstein et al. (16 authors)
Neurotherapeutics
Open Access
Published: Feb 2020
28 citations
28 citations
960 days before retraction
5-LIPOXYGENASE INHIBITOR (ZILEUTON) PRODUCES ANTI-DEPRESSION EFFECT IN STRESS INDUCE CRS MICE MODEL
Saptarshi Panigrahi, Somnath Surai, Hao Hong
Asian Journal of Pharmaceutical and Clinical Research
Open Access
Published: Dec 2019
1 citation
1 citation
1012 days before retraction
Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration
Changmo Kim, Izhar Livne‐Bar, Karsten Gronert et al. (4 authors)
Molecular Nutrition & Food Research
Open Access
Published: Dec 2019
17 citations
17 citations
1036 days before retraction
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar et al. (10 authors)
Nature Communications
Open Access
Published: Aug 2019
276 citations
276 citations
1133 days before retraction
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Rongcan Luo, Ling-Yan Su, Guiyu Li et al. (12 authors)
Autophagy
Open Access
Published: Mar 2019
296 citations
296 citations
1293 days before retraction
The leukotriene signaling pathway: a druggable target in Alzheimer’s disease
Johanna Michael, Julia Marschallinger, Ludwig Aigner
Drug Discovery Today
Open Access
Published: Sep 2018
57 citations
57 citations
1478 days before retraction
Leukotriene biosynthetic enzymes as therapeutic targets
Jesper Z. Haeggström
Journal of Clinical Investigation
Open Access
Published: Jul 2018
142 citations
142 citations
1557 days before retraction
Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase
Elisabetta Lauretti, Domenico Praticò
Journal of Alzheimer s Disease
Open Access
Published: May 2018
9 citations
9 citations
1608 days before retraction
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy
Antonio Di Meco, Jianguo Li, Carlos A. Barrero et al. (5 authors)
Molecular Psychiatry
Open Access
Published: Apr 2018
29 citations
29 citations
1619 days before retraction
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
Phillip F. Giannopoulos, Jian Chiu, Domenico Praticò
Aging Cell
Open Access
Published: Apr 2018
17 citations
17 citations
1648 days before retraction
The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Translational Psychiatry
Open Access
Published: Dec 2017
30 citations
30 citations
1755 days before retraction
Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology
Antonio Di Meco, Li Jianguo, Domenico Praticò
Journal of Alzheimer s Disease
Open Access
Published: Dec 2017
17 citations
17 citations
1758 days before retraction
Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre et al. (4 authors)
Pharmacological Reviews
Open Access
Published: Dec 2017
357 citations
357 citations
1763 days before retraction
Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice
Dandan Li, Hang Xie, Yifeng Du et al. (9 authors)
Journal of Affective Disorders
Published: Nov 2017
27 citations
27 citations
1787 days before retraction
RETRACTED ARTICLE: Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
Phillip F. Giannopoulos, Domenico Praticò
Molecular Neurobiology
Published: Nov 2017
15 citations
15 citations
1789 days before retraction
Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Aging Cell
Open Access
Published: Nov 2017
35 citations
35 citations
1796 days before retraction
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
Jianguo Li, Carlos A. Barrero, Salim Merali et al. (4 authors)
Scientific Reports
Open Access
Published: Apr 2017
28 citations
28 citations
2008 days before retraction
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology
Jianguo Li, Carlos A. Barrero, Salim Merali et al. (4 authors)
Human Molecular Genetics
Open Access
Published: Mar 2017
11 citations
11 citations
2038 days before retraction
Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease
Jin Chu, Elisabetta Lauretti, Domenico Praticò
Molecular Psychiatry
Published: Jan 2017
82 citations
82 citations
2073 days before retraction
Potential Treatments for Alzheimer’s Disease
Akhlaq A. Farooqui
Elsevier eBooks
Published: Jan 2017
2103 days before retraction
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation
Li Jianguo, Carlos A. Barrero, Sapna Gupta et al. (6 authors)
Aging Cell
Open Access
Published: Nov 2016
44 citations
44 citations
2136 days before retraction
The mechanism of 5-lipoxygenase in the impairment of learning and memory in rats subjected to chronic unpredictable mild stress
Ying Luo, Shengnan Kuang, Lai Xue et al. (4 authors)
Physiology & Behavior
Published: Sep 2016
33 citations
33 citations
2210 days before retraction
The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target
Jin Chu, Domenico Praticò
Brain Research Bulletin
Open Access
Published: Mar 2016
34 citations
34 citations
2391 days before retraction
Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index
Omar Šerý, Lýdia Hlinecká, Jana Povová et al. (9 authors)
Journal of the Neurological Sciences
Published: Jan 2016
28 citations
28 citations
2455 days before retraction
N-3 PUFAs and neuroinflammatory processes in cognitive disorders
Quentin Leyrolle, Sophie Layé, Agnès Nadjar
OCL
Open Access
Published: Jan 2016
1 citation
1 citation
2469 days before retraction
The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
Grzegorz A. Czapski, Kinga Czubowicz, Joanna B. Strosznajder et al. (4 authors)
Neurochemical Research
Open Access
Published: Dec 2015
116 citations
116 citations
2485 days before retraction
Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways
Jee Hyun Yi, Hey Jin Park, Seungheon Lee et al. (8 authors)
Journal of Ethnopharmacology
Published: Dec 2015
46 citations
46 citations
2489 days before retraction
Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?
David Vauzour, Anneloes Martinsen, Sophie Layé
Neurochemistry International
Open Access
Published: Aug 2015
54 citations
54 citations
2615 days before retraction
The role of lipoxygenases in pathophysiology; new insights and future perspectives
Ryuichi Mashima, Torayuki Okuyama
Redox Biology
Open Access
Published: Aug 2015
368 citations
368 citations
2615 days before retraction
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence
Jin Chu, Jianguo Li, Nicholas E. Hoffman et al. (6 authors)
Scientific Reports
Open Access
Published: Jun 2015
9 citations
9 citations
2668 days before retraction
RETRACTED: Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy
Phillip F. Giannopoulos, Jin Chu, Margaret Sperow et al. (8 authors)
Biological Psychiatry
Open Access
Published: Feb 2015
45 citations
45 citations
2797 days before retraction
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
Yash B. Joshi, D PraticÃ
Frontiers in Cellular Neuroscience
Open Access
Published: Jan 2015
67 citations
67 citations
2821 days before retraction
Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice
Jin Chu, J. G. Li, Phillip F. Giannopoulos et al. (7 authors)
Molecular Psychiatry
Open Access
Published: Jan 2015
41 citations
41 citations
2829 days before retraction
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor
Elisabetta Lauretti, Antonio Di Meco, Jin Chu et al. (4 authors)
Neurobiology of Aging
Published: Oct 2014
12 citations
12 citations
2914 days before retraction
Retracted: Absence of <i>ALOX5</i> gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease
Yash B. Joshi, Phillip F. Giannopoulos, Jin Chu et al. (7 authors)
Human Molecular Genetics
Open Access
Published: Aug 2014
30 citations
30 citations
2975 days before retraction
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014
Wolfgang Froestl, Andreas Muhs, Andrea Pfeifer
Journal of Alzheimer s Disease
Published: Aug 2014
24 citations
24 citations
2977 days before retraction
Pharmacological Modulation of GSAP Reduces Amyloid-β Levels and Tau Phosphorylation in a Mouse Model of Alzheimer's Disease with Plaques and Tangles
Jin Chu, Elisabetta Lauretti, Caryne P. Craige et al. (4 authors)
Journal of Alzheimer s Disease
Published: Jul 2014
32 citations
32 citations
3003 days before retraction
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice
Antonio Di Meco, Elisabetta Lauretti, Alana N. Vagnozzi et al. (4 authors)
Neurobiology of Aging
Open Access
Published: May 2014
61 citations
61 citations
3053 days before retraction
Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles
Jianguo Li, Jin Chu, Carlos A. Barrero et al. (5 authors)
Annals of Neurology
Open Access
Published: Mar 2014
116 citations
116 citations
3122 days before retraction
Quick Stats
Total Citations:
55
Years Since Retraction:
3.1 years
Open Access:
Yes
Last Checked:
Jul 24, 2025