Expression of concern
FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity
Paper Information
Record ID:
40797
Author(s):
Journal:
Publication Date:
July 29, 2022
Retraction Date:
November 11, 2022
(3.0 years years ago)
Subjects:
Institutions:
- Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China
- “2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China
- Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A
- Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200040, China
Country:
🇨🇳 ChinaArticle Type:
Publisher:
Portland Press
Open Access:
Yes
DOI:
PubMed ID:
Retraction PubMed ID:
Expression of concern Details
Retraction Reasons:
Nature of Retraction:
Expression of concern
Retraction Notice:
10.1042/BSR-2015-0032_EOCCitations (32)
32
Total Citations9
Post-Retraction(28.1%)
23
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
1
Within 30 days
6
Within 1 year
0
After 2+ years
592
Days since retraction (latest)
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The role of the Rho family small GTPases in regulation of normal and pathological processes
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Role of Rho Family Small GTPases in the Regulation of Normal and Pathological Processes
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Cell and Tissue Biology
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1 citation
568 days after retraction
Efficacy and mechanism of Wuzi Yanzong pill on the prevention and treatment of EAE
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Heliyon
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324 days after retraction
Paper citing FSD-C10: A more promising novel ROCK inhibitor tha...
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298 days after retraction
Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies
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Neural Regeneration Research
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2 citations
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276 days after retraction
Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis
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Neural Regeneration Research
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7 citations
7 citations
251 days after retraction
Therapeutic Perspectives on ROCK Inhibition for Cerebral Cavernous Malformations
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Kinases and Phosphatases
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5 citations
5 citations
104 days after retraction
Neuroprotective effects of nobiletin on cerebral ischemia/reperfusion injury rats by inhibiting Rho/ROCK signaling pathway
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205 days before retraction
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases
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Neural Regeneration Research
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40 citations
40 citations
314 days before retraction
Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
William Guiler, Addison Koehler, Christi Boykin et al. (4 authors)
Frontiers in Cellular Neuroscience
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44 citations
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548 days before retraction
Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice
Wenyue Wei, Yuyin Wang, Jing Zhang et al. (10 authors)
Folia Neuropathologica
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26 citations
26 citations
679 days before retraction
Computational systematic selectivity of the Fasalog inhibitors between ROCK-I and ROCK-II kinase isoforms in Alzheimer’s disease
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Computational Biology and Chemistry
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4 citations
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871 days before retraction
Paper citing FSD-C10: A more promising novel ROCK inhibitor tha...
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Unknown Journal
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1161 days before retraction
Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage
Gonzalo I. Gómez, Victoria Velarde, Juan C. Sáez
International Journal of Molecular Sciences
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Published: Sep 2019
25 citations
25 citations
1161 days before retraction
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease
Lisa McKerracher, Robert Shenkar, Matthew Abbinanti et al. (16 authors)
Translational Stroke Research
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36 citations
36 citations
1175 days before retraction
Behavioural phenotypes in the cuprizone model of central nervous system demyelination
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Neuroscience & Biobehavioral Reviews
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83 citations
83 citations
1179 days before retraction
Protein Kinase Inhibitors for the Treatment of Multiple Sclerosis
Ana Martı́nez, Carmen Gil
The Royal Society of Chemistry eBooks
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1242 days before retraction
Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis
Shang‐De Guo, Chunyun Liu, Jingwen Yu et al. (12 authors)
CNS Neuroscience & Therapeutics
Open Access
Published: Feb 2019
14 citations
14 citations
1362 days before retraction
Protective effects of the ROCK inhibitor fasudil against cognitive dysfunction following status epilepticus in male rats
Xiaojie Song, Rong He, Wei Han et al. (9 authors)
Journal of Neuroscience Research
Published: Nov 2018
16 citations
16 citations
1460 days before retraction
Therapeutic effect of Rho kinase inhibitor FSD‑C10 in a mouse model of Alzheimer's disease
Qingfang Gu, Jie‐Zhong Yu, Hao Wu et al. (9 authors)
Experimental and Therapeutic Medicine
Open Access
Published: Sep 2018
23 citations
23 citations
1528 days before retraction
FSD-C10 Shows Therapeutic Effects in Suppressing oxidized low-density lipoprotein (ox-LDL)-Induced Human Brain Microvascular Endothelial Cells Apoptosis via Rho-Associated Coiled-Coil Kinase (ROCK)/Mitogen-Activated Protein Kinase (MAPK) Signaling
Xin Wang, Rongyan Mao, Weiwei Chen
Medical Science Monitor
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Published: Aug 2018
5 citations
5 citations
1556 days before retraction
Fasudil in Combination With Bone Marrow Stromal Cells (BMSCs) Attenuates Alzheimer’s Disease-Related Changes Through the Regulation of the Peripheral Immune System
Jie‐Zhong Yu, Yuqing Yan, Qingfang Gu et al. (15 authors)
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15 citations
15 citations
1579 days before retraction
Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease
Zhongwei Liu, Raouf A. Khalil
Biochemical Pharmacology
Open Access
Published: Feb 2018
138 citations
138 citations
1731 days before retraction
The Rho-associated kinase inhibitors Y27632 and fasudil promote microglial migration in the spinal cord via the ERK signaling pathway
Xiang Luo, Peicai Fu, Ronghua Tang et al. (6 authors)
Neural Regeneration Research
Open Access
Published: Jan 2018
21 citations
21 citations
1775 days before retraction
Rho‐associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease
Aaron Y. Lai, JoAnne McLaurin
Journal of Neurochemistry
Open Access
Published: Jul 2017
29 citations
29 citations
1941 days before retraction
Paper citing FSD-C10: A more promising novel ROCK inhibitor tha...
Unknown Authors
Unknown Journal
Published: Feb 2017
2095 days before retraction
FSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms
Yànhuá Lǐ, Chong Xie, Yuan Zhang et al. (11 authors)
Scientific Reports
Open Access
Published: Jan 2017
23 citations
23 citations
2118 days before retraction
Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis
Jingwen Yu, Yanhua Li, Guobin Song et al. (12 authors)
Journal of Molecular Neuroscience
Published: Aug 2016
17 citations
17 citations
2264 days before retraction
Fasudil inhibits LPS-induced migration of retinal microglial cells via regulating p38-MAPK signaling pathway.
Fan Xu, Yue Xu, Liqiong Zhu et al. (8 authors)
PubMed
Published: Jan 2016
9 citations
9 citations
2506 days before retraction
High-throughput screening against $$\sim $$ ∼ 6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery
Gong Hao-ling, Zhicheng Yuan, Liping Zhan
Molecular Diversity
Published: Dec 2015
9 citations
9 citations
2515 days before retraction
Quick Stats
Total Citations:
32
Years Since Retraction:
3.0 years
Open Access:
Yes
Last Checked:
Jul 24, 2025