Retraction
Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase (RRM2): a novel therapeutic strategy in pancreatic cancer
Paper Information
Record ID:
42612
Author(s):
Publication Date:
August 04, 2004
Retraction Date:
February 10, 2023
(2.8 years years ago)
Subjects:
Institution:
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass USACountry:
🇺🇸 United StatesArticle Type:
Publisher:
Elsevier
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (58)
58
Total Citations1
Post-Retraction(1.7%)
57
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
1
Within 30 days
1
Within 1 year
0
After 2+ years
5
Days since retraction (latest)
microRNAs Associated with Gemcitabine Resistance via EMT, TME, and Drug Metabolism in Pancreatic Cancer
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Cancers
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12 citations
12 citations
5 days after retraction
Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
Zanwen Zuo, Zerong Zhou, Yuzhou Chang et al. (7 authors)
Genes & Diseases
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Published: Dec 2022
56 citations
56 citations
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Gemcitabine Resistance in Pancreatic Ductal Carcinoma Cell Lines Stems from Reprogramming of Energy Metabolism
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International Journal of Molecular Sciences
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17 citations
17 citations
210 days before retraction
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment
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Mini-Reviews in Medicinal Chemistry
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4 citations
4 citations
322 days before retraction
Harnessing pH-Sensitive Polycation Vehicles for the Efficient siRNA Delivery
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ACS Applied Materials & Interfaces
Published: Jan 2021
34 citations
34 citations
764 days before retraction
MiR-20a-5p regulates gemcitabine chemosensitivity by targeting RRM2 in pancreatic cancer cells and serves as a predictor for gemcitabine-based chemotherapy
Huimin Lü, Shan Lu, Dujiang Yang et al. (7 authors)
Bioscience Reports
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Published: Feb 2019
35 citations
35 citations
1453 days before retraction
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OncoTargets and Therapy
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24 citations
24 citations
1501 days before retraction
Small Molecules and Pancreatic Cancer Trials and Troubles
Sneha Govardhanagiri, Shipra Reddy Bethi, Ganji Purnachandra Nagaraju
Elsevier eBooks
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16 citations
16 citations
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Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer
Kei Kawaguchi, Kentaro Miyake, Qinghong Han et al. (17 authors)
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78 citations
78 citations
1697 days before retraction
The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers
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Biomaterials
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Published: May 2018
51 citations
51 citations
1718 days before retraction
Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment
Xiao Zhao, Xiuchao Wang, Wei Sun et al. (17 authors)
Biomaterials
Published: Dec 2017
31 citations
31 citations
1878 days before retraction
Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
Guanggai Xia, Hongcheng Wang, Ziliang Song et al. (6 authors)
Journal of Experimental & Clinical Cancer Research
Open Access
Published: Aug 2017
81 citations
81 citations
2010 days before retraction
Drug resistance in pancreatic cancer: Impact of altered energy metabolism
Cristoforo Grasso, Gerrit Jansen, Elisa Giovannetti
Critical Reviews in Oncology/Hematology
Open Access
Published: Mar 2017
224 citations
224 citations
2150 days before retraction
Utilization of a PNA-peptide conjugate to induce a cancer protease-responsive RNAi effect
Eun Kyung Lee, Chan Woo Kim, Hiroyuki Kawanami et al. (7 authors)
RSC Advances
Published: Jan 2015
1 citation
1 citation
2962 days before retraction
Investigation of approaches for overcoming chemoresistance in pancreatic cancer
Sau Wai Hung
Unknown Journal
Published: Aug 2014
3115 days before retraction
Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
Yimon Aye, M Li, Marcus J. C. Long et al. (4 authors)
Oncogene
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Published: Jun 2014
396 citations
396 citations
3168 days before retraction
Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma
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Oncology Reports
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Published: Apr 2014
17 citations
17 citations
3215 days before retraction
Targeting ribonucleotide reductase for cancer therapy
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Expert Opinion on Therapeutic Targets
Published: Oct 2013
84 citations
84 citations
3419 days before retraction
<i>IN VIVO</i> IMAGING AND DELIVERY OF siRNA
Zdravka Medarova, Anna Moore
Unknown Journal
Published: Sep 2013
1 citation
1 citation
3430 days before retraction
Small Interfering RNA (siRNA)-Mediated Silencing of the M2 Subunit of Ribonucleotide Reductase
Meng Zhang, Jing Wang, Ruyong Yao et al. (4 authors)
International Journal of Gynecological Cancer
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25 citations
25 citations
3628 days before retraction
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3876 days before retraction
Paper citing Retrovirally mediated RNA interference targeting t...
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3937 days before retraction
Human Telomerase Reverse Transcriptase Gene Antisense Oligonucleotide Increases the Sensitivity of Pancreatic Cancer Cells to Gemcitabine In Vitro
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InTech eBooks
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Published: Mar 2012
3976 days before retraction
Overcoming nucleoside analog chemoresistance of pancreatic cancer: A therapeutic challenge
Sau Wai Hung, Hardik Mody, Rajgopal Govindarajan
Cancer Letters
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Published: Mar 2012
80 citations
80 citations
3986 days before retraction
Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth
Mohammad Aminur Rahman, A.R.M. Ruhul Amin, Xu Wang et al. (14 authors)
Journal of Controlled Release
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Published: Feb 2012
87 citations
87 citations
4020 days before retraction
Vaccinia Virus–Encoded Ribonucleotide Reductase Subunits Are Differentially Required for Replication and Pathogenesis
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PLoS Pathogens
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86 citations
86 citations
4600 days before retraction
The role of 5'-nucleotidases and Deoxynucleoside Kinases in Responses to Nucleoside Analogues
Saeedeh Mirzaee
Unknown Journal
Published: Apr 2010
4669 days before retraction
Inhibitory RNA Molecules in Immunotherapy for Cancer
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Methods in molecular biology
Open Access
Published: Jan 2010
12 citations
12 citations
4788 days before retraction
RNA interference: a potent technology in studying and modulating of dendritic cells, and potential in clinical therapy
Cheng Fang, Song He
Molecular Biology Reports
Published: Sep 2009
5 citations
5 citations
4900 days before retraction
Long‐term RNA interference and its application to hepatitis B virus
Jin‐Shui Pan, Xiao Zhong Wang, Jian Ren
Journal of Digestive Diseases
Published: Jul 2009
6 citations
6 citations
4950 days before retraction
Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase.
Glen Reid, Natacha Coppieters, Rachna Patel et al. (8 authors)
PubMed
Published: Mar 2009
32 citations
32 citations
5086 days before retraction
Paper citing RNAi-mediated inhibition of cathepsin B and uPAR l...
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5094 days before retraction
Tumor BRCA1, RRM1 and RRM2 mRNA Expression Levels and Clinical Response to First-Line Gemcitabine plus Docetaxel in Non-Small-Cell Lung Cancer Patients
Ioannis Boukovinas, Chara Papadaki, Pedro Méndez et al. (13 authors)
PLoS ONE
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Published: Nov 2008
126 citations
126 citations
5205 days before retraction
Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer.
Seiji Ohhashi, Kenoki Ohuchida, Kazuhiro Mizumoto et al. (10 authors)
PubMed
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106 citations
106 citations
5277 days before retraction
Paper citing Retrovirally mediated RNA interference targeting t...
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5398 days before retraction
Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
John Souglakos, Ioannis Boukovinas, Miquel Tarón et al. (11 authors)
British Journal of Cancer
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Published: Apr 2008
115 citations
115 citations
5414 days before retraction
Paper citing Retrovirally mediated RNA interference targeting t...
Unknown Authors
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5428 days before retraction
Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine
Hamdi Jarjanazi, Jeffrey Kiefer, Sevtap Savas et al. (9 authors)
Human Mutation
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20 citations
20 citations
5450 days before retraction
Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players
Michael P. Kim, Gary E. Gallick
Clinical Cancer Research
Published: Mar 2008
166 citations
166 citations
5459 days before retraction
siRNAs with high specificity to a target: A systematic design by the CRM algorithm
Tariq Alsheddi, Л. А. Васин, Ramakrishna Meduri et al. (6 authors)
Molecular Biology
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7 citations
7 citations
5488 days before retraction
Down-regulation of CXCR4 by Inducible Retrovirally Mediated RNA Interference Inhibits Human Cervix Carcinoma Cell Invasion in Vitro
Hu Li
Clinical Oncology and Cancer Research
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5519 days before retraction
Gemcitabine
Andries M. Bergman, Godefridus J. Peters
Humana Press eBooks
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1 citation
1 citation
5575 days before retraction
An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK
Pachiyappan Kamarajan, Yvonne L. Kapila
APOPTOSIS
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32 citations
32 citations
5624 days before retraction
Effects of tumor selective replication-competent herpes viruses in combination with gemcitabine on pancreatic cancer
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Cancer Chemotherapy and Pharmacology
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39 citations
39 citations
5645 days before retraction
Review of recent studies on resistance to cytotoxic deoxynucleoside analogues
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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85 citations
85 citations
5658 days before retraction
RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research
Hong Chang
Cancer Gene Therapy
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31 citations
31 citations
5733 days before retraction
Immunological research using RNA interference technology
Chih‐Ping Mao, Yen‐Yu Lin, Chien‐Fu Hung et al. (4 authors)
Immunology
Open Access
Published: Apr 2007
18 citations
18 citations
5783 days before retraction
Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation <i>In vitro</i> and <i>In vivo</i>
Jeremy D. Heidel, Joanna Yi-Ching Liu, Yun Yen et al. (8 authors)
Clinical Cancer Research
Open Access
Published: Apr 2007
159 citations
159 citations
5794 days before retraction
RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo
Tina Avolio, Yoon Lee, Ningping Feng et al. (9 authors)
Anti-Cancer Drugs
Published: Feb 2007
14 citations
14 citations
5828 days before retraction
RRM2 induces NF-κB-dependent MMP-9 activation and enhances cellular invasiveness
Mark Duxbury, Edward E. Whang
Biochemical and Biophysical Research Communications
Published: Dec 2006
87 citations
87 citations
5886 days before retraction
Quick Stats
Total Citations:
58
Years Since Retraction:
2.8 years
Open Access:
Yes
Last Checked:
Jul 24, 2025