Expression of concern
PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis
Paper Information
Record ID:
43648
Journal:
Publication Date:
March 31, 2017
Retraction Date:
March 01, 2022
(3.7 years years ago)
Subjects:
Institutions:
- Department of Physiology, Pharmacology and Neuroscience, City University of New York School of Medicine, New York, NY, USA
- Department of Biology and Neuroscience, Graduate school of the City University of New York, New York, NY, USA
- Department of Physiology, Pharmacology and Neuroscience, City University of New York School of Medicine, New York, NY, USA
- Department of Physiology, Pharmacology and Neuroscience, City University of New York School of Medicine, New York, NY, USA
- Department of Biology and Neuroscience, Graduate school of the City University of New York, New York, NY, USA
- Pain Therapeutics, Inc, Austin, TX, USA
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Elsevier
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Not indexed in PubMed
Expression of concern Details
Retraction Reason:
Nature of Retraction:
Expression of concern
Retraction Notice:
10.1016/j.neurobiolaging.2022.03.012Citations (39)
39
Total Citations24
Post-Retraction(61.5%)
15
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
8
Within 1 year
4
After 2+ years
1193
Days since retraction (latest)
The Emerging Role of Filamin A and FLNA Gene in Central Nervous System Functions: Insights into Neurodevelopment and Disease
Nikita I Golushko, A. D. Shevlyakov, Daniil Martynov et al. (6 authors)
Journal of Integrative Neuroscience
Open Access
Published: Jun 2025
1193 days after retraction
Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications
Nagaraju Bandaru, Sarad Pawar Naik Bukke, Veera Mani Deepika Pedapati et al. (10 authors)
Drugs and Drug Candidates
Open Access
Published: May 2025
1172 days after retraction
The potential of ARL4C and its-mediated genes in atherosclerosis and agent development
Shilin Liu, Jie Wang, Shuangshuang Zhang et al. (7 authors)
Frontiers in Pharmacology
Open Access
Published: Mar 2025
1114 days after retraction
Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus
Pavel P. Tregub, Yulia K. Komleva, Maria V. Kukla et al. (8 authors)
Cells
Open Access
Published: Jan 2025
4 citations
4 citations
1055 days after retraction
A Systematic Review on Drugs Acting as Nicotinic Acetylcholine Receptor Agonists in the Treatment of Dementia
Alessio Crestini, Elena Carbone, Roberto Rivabene et al. (11 authors)
Cells
Open Access
Published: Jan 2024
9 citations
9 citations
696 days after retraction
Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Marzia Di Donato, Antimo Moretti, Carmela Sorrentino et al. (8 authors)
Cell Death Discovery
Open Access
Published: Dec 2023
6 citations
6 citations
641 days after retraction
Insights to develop tau‐directed therapeutics to protect the synaptic integrity for tauopathies
Eunji Cha, Hak Joong Kim, Sang Min Lim
Bulletin of the Korean Chemical Society
Published: Oct 2023
3 citations
3 citations
598 days after retraction
Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification
Jeffrey L. Cummings, Amanda M. Leisgang Osse, Jefferson W. Kinney
Drugs
Open Access
Published: Sep 2023
71 citations
71 citations
568 days after retraction
Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer’s Disease
Hoau-Yan Wang, Erika Cecon, Julie Dam et al. (6 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2023
14 citations
14 citations
559 days after retraction
Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies
Francesca R. Buccellato, Marianna D’Anca, Gianluca Martino Tartaglia et al. (6 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2023
55 citations
55 citations
557 days after retraction
Failure, Success, and Future Direction of Alzheimer Drugs Targeting Amyloid‐β Cascade: Pros and Cons of Chemical and Biological Modalities
Jimin Kim, Hanna Jeon, Hye Yun Kim et al. (4 authors)
ChemBioChem
Published: Jul 2023
8 citations
8 citations
513 days after retraction
Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Yun Zhang, Huaqiu Chen, Ran Li et al. (5 authors)
Signal Transduction and Targeted Therapy
Open Access
Published: Jun 2023
455 citations
455 citations
486 days after retraction
Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes
Hoau-Yan Wang, Zhe Pei, Kuo-Chieh Lee et al. (8 authors)
Frontiers in Aging
Open Access
Published: Jun 2023
7 citations
7 citations
485 days after retraction
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development
Lindsay H. Burns, Zhe Pei, Hoau‐Yan Wang
Drug Development Research
Published: Jun 2023
27 citations
27 citations
464 days after retraction
Alzheimer’s Disease Treatment: The Search for a Breakthrough
Allison B. Reiss, Dalia Muhieddine, Berlin Jacob et al. (9 authors)
Medicina
Open Access
Published: Jun 2023
20 citations
20 citations
460 days after retraction
Therapies for Tau-associated neurodegenerative disorders: targeting molecules, synapses, and cells
Miranda Robbins
Neural Regeneration Research
Open Access
Published: Apr 2023
10 citations
10 citations
408 days after retraction
Alzheimer’s drug saga prompts journal to scrutinize whistle-blowers
Holly Else
Nature
Open Access
Published: Jan 2023
3 citations
3 citations
317 days after retraction
Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy
Brandon Lucke‐Wold
Biomedical Research and Clinical Reviews
Open Access
Published: Dec 2022
4 citations
4 citations
297 days after retraction
Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease
Étienne Aumont, Cyntia Tremblay, Stéphanie Levert et al. (6 authors)
Frontiers in Aging Neuroscience
Open Access
Published: Nov 2022
6 citations
6 citations
268 days after retraction
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
Stéphanie Levert, Julie Pilliod, Étienne Aumont et al. (7 authors)
Molecular Neurobiology
Open Access
Published: Nov 2022
6 citations
6 citations
262 days after retraction
Scaffold proteins as dynamic integrators of biological processes
Christopher J. DiRusso, Maryam Dashtiahangar, Thomas D. Gilmore
Journal of Biological Chemistry
Open Access
Published: Oct 2022
35 citations
35 citations
233 days after retraction
Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis
Ilaria Tortorella, Chiara Argentati, Carla Emiliani et al. (5 authors)
Cells
Open Access
Published: Oct 2022
28 citations
28 citations
214 days after retraction
Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia
Boris Decourt, Keith Noorda, Kevin Noorda et al. (5 authors)
Journal of Experimental Pharmacology
Open Access
Published: Oct 2022
20 citations
20 citations
214 days after retraction
Amyloid-beta Targeted Therapeutic Approaches for Alzheimer’s Disease: Long Road Ahead
Yuxuan Dai, Chenyi Lei, Zhenhao Zhang et al. (6 authors)
Current Drug Targets
Published: Apr 2022
9 citations
9 citations
52 days after retraction
Amyloid Cascade Hypothesis for the Treatment of Alzheimer’s Disease: Progress and Challenges
Tong Wu, Lin Ding, Ya‐Qian Cheng et al. (9 authors)
Aging and Disease
Open Access
Published: Jan 2022
43 citations
43 citations
59 days before retraction
Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease
Rishika Dhapola, Subhendu Shekhar Hota, Phulen Sarma et al. (6 authors)
Inflammopharmacology
Open Access
Published: Nov 2021
264 citations
264 citations
98 days before retraction
Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain
Siobhan Robinson, Allison S. Mogul, Elisa M. Taylor-Yeremeeva et al. (6 authors)
Neuroscience
Open Access
Published: Jul 2021
13 citations
13 citations
223 days before retraction
Cognition
Richard Young
Burger's Medicinal Chemistry and Drug Discovery
Published: Apr 2021
309 days before retraction
The function and pathogenic mechanism of filamin A
Jie Zhou, Xinmei Kang, Han‐Xiang An et al. (5 authors)
Gene
Published: Mar 2021
69 citations
69 citations
348 days before retraction
Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer’s Disease
Sofia Toniolo, Arjune Sen, Masud Husain
International Journal of Molecular Sciences
Open Access
Published: Dec 2020
74 citations
74 citations
449 days before retraction
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
Ryan P. Kreiser, Aidan K. Wright, Natalie R. Block et al. (9 authors)
International Journal of Molecular Sciences
Open Access
Published: Nov 2020
35 citations
35 citations
469 days before retraction
Primate differential redoxome (PDR) – A paradigm for understanding neurodegenerative diseases
Nachiyappan Venkatachalam, Shamchal Bakavayev, Daniel R. Engel et al. (5 authors)
Redox Biology
Open Access
Published: Aug 2020
3 citations
3 citations
566 days before retraction
Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations
Longbo Zhang, Tianxiang Huang, Shannon Teaw et al. (8 authors)
Science Translational Medicine
Open Access
Published: Feb 2020
43 citations
43 citations
741 days before retraction
Aβ42-α7-like nicotinic acetylcholine receptors and Alzheimer’s disease
Hoau-Yan Wang, Amber Khan
Elsevier eBooks
Published: Jan 2020
2 citations
2 citations
790 days before retraction
PTI-125 REDUCES BIOMARKERS OF ALZHEIMER’S DISEASE IN PATIENTS
H.-Y. Wang, Zhen‐Ming Pei, K.-C. Lee et al. (10 authors)
The Journal of Prevention of Alzheimer s Disease
Published: Jan 2020
35 citations
35 citations
790 days before retraction
A model of lipid dysregulation and altered nutrient status in Alzheimer's disease
Keith Fluegge
Alzheimer s & Dementia Translational Research & Clinical Interventions
Open Access
Published: Jan 2019
7 citations
7 citations
1155 days before retraction
Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review
Maria Avila-Vazquez, Nelly Altamirano-Bustamante, Myriam M. Altamirano‐Bustamante
Molecules
Open Access
Published: Dec 2017
9 citations
9 citations
1523 days before retraction
Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer’s disease
Lindsay H. Burns, Hoau-Yan Wang
Neuroimmunology and Neuroinflammation
Open Access
Published: Dec 2017
25 citations
25 citations
1544 days before retraction
RETRACTED ARTICLE: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis
Hoau-Yan Wang, Caryn Trocme‐Thibierge, Andres Stucky et al. (15 authors)
Alzheimer s Research & Therapy
Open Access
Published: Jul 2017
14 citations
14 citations
1678 days before retraction
Quick Stats
Total Citations:
39
Years Since Retraction:
3.7 years
Open Access:
Yes
Last Checked:
Jul 24, 2025