Retraction
Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies
Paper Information
Record ID:
48633
Author(s):
Publication Date:
October 25, 2010
Retraction Date:
September 19, 2023
(2.2 years years ago)
Subjects:
Institutions:
- Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada
- Department of Chemical and Physical Sciences, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada
- Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, 6900 Lake Nona Boulevard, Orlando, Florida 32827, United States
Countries:
Article Type:
Publisher:
American Chemical Society (ACS)
Open Access:
Yes
DOI:
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
Nature of Retraction:
Retraction
Retraction Notice:
10.1021/acsmedchemlett.3c00405Additional Notes:
see also: https://pubpeer.com/publications/6F8751BC51B45ED295C7EFD0BB31AD
Citations (39)
39
Total Citations2
Post-Retraction(5.1%)
37
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
0
Within 1 year
0
After 2+ years
652
Days since retraction (latest)
Revisiting multi-pathway modulation with theophylline derivatives: Targeting STAT3, NF-κB, and apoptotic signaling in breast cancer
Ola S Afifi, Amira A. Abdellatef, Heba A. Abd El Razik et al. (10 authors)
Bioorganic Chemistry
Published: Jul 2025
652 days after retraction
Facile green diversity-oriented synthesis, molecular docking, and cytotoxicity evaluation of quinoline -triazole appended peptidomimetics as inhibitors of human breast cancer cell line MCF-7
K. Ramya, Seena Chakko, V. S. Shinu et al. (6 authors)
Results in Chemistry
Open Access
Published: Mar 2025
529 days after retraction
Discovery of STAT3 Inhibitors: Recent Advances and Future Perspectives
Jiatao Song, Jiawei Wang, Sheng Tian et al. (4 authors)
Current Medicinal Chemistry
Published: Aug 2022
22 citations
22 citations
395 days before retraction
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation
Jinyun Dong, Xiangdong Cheng, Weidong Zhang et al. (4 authors)
Journal of Medicinal Chemistry
Published: Jun 2021
162 citations
162 citations
816 days before retraction
BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells <i>via</i> the signal transducer and activator of transcription 3/fascin-1 pathway
Guodong Qian, Jian Xu, Xiaoxu Shen et al. (8 authors)
International Journal of Neuroscience
Published: Apr 2020
3 citations
3 citations
1243 days before retraction
Triazolopyrimidinium Salts: Discovery of a New Class of Agents for Cancer Therapy
Mariateresa Badolato, Fabrizio Manetti, Antonio Garofalo et al. (4 authors)
Future Medicinal Chemistry
Published: Feb 2020
3 citations
3 citations
1320 days before retraction
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Qiuyao Huang, Yan Zhong, Hui Dong et al. (10 authors)
European Journal of Medicinal Chemistry
Published: Nov 2019
73 citations
73 citations
1391 days before retraction
Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3
Xuebao Wang, Qin He, Kaiqi Wu et al. (10 authors)
European Journal of Medicinal Chemistry
Published: Jun 2019
20 citations
20 citations
1551 days before retraction
STAT3: A Potential Drug Target for Tumor and Inflammation
Yang Hu, Xu Han, Xin Hua Liu
Current Topics in Medicinal Chemistry
Published: Jun 2019
63 citations
63 citations
1552 days before retraction
Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer
Wei Wen, Ernest Han, Thanh H. Dellinger et al. (9 authors)
Translational Oncology
Open Access
Published: May 2019
9 citations
9 citations
1577 days before retraction
An efficient green diversity oriented synthesis of pyrimidinone and indole appended macrocyclic peptidomimetics
Rajeena Pathoor, Thasnim Puthiyedath, D. Bahulayan
Tetrahedron Letters
Published: Dec 2018
4 citations
4 citations
1749 days before retraction
Computational Approaches in the Development of Small-molecule Transcription Factor Inhibitors
Paul J. Jackson, Shirin Jamshidi, Doaa Boshra Farag
The Royal Society of Chemistry eBooks
Published: Sep 2018
2 citations
2 citations
1840 days before retraction
Targeting Signal Transducer and Activator of Transcripion (STAT) 3 with Small Molecules
Andrew E. Shouksmith, Patrick T. Gunning
The Royal Society of Chemistry eBooks
Published: Sep 2018
1 citation
1 citation
1840 days before retraction
MCR-click synthesis, molecular docking and cytotoxicity evaluation of a new series of indole–triazole–coumarin hybrid peptidomimetics
Rajeena Pathoor, D. Bahulayan
New Journal of Chemistry
Published: Jan 2018
28 citations
28 citations
2087 days before retraction
STAT3 Inhibitors in Cancer: A Comprehensive Update
Uddalak Bharadwaj, Moses M. Kasembeli, David J. Tweardy
Cancer drug discovery and develogment/Cancer drug discovery and development
Published: Jan 2016
20 citations
20 citations
2818 days before retraction
A STAT inhibitor patent review: progress since 2011
Ping‐Shan Lai, David A. Rosa, Ahmed M. Ali et al. (7 authors)
Expert Opinion on Therapeutic Patents
Published: Sep 2015
55 citations
55 citations
2919 days before retraction
Rhodium(II) Proximity‐Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti‐Leukemia Activity
Matthew B. Minus, Wei Liu, Farrukh Vohidov et al. (12 authors)
Angewandte Chemie
Published: Sep 2015
13 citations
13 citations
2934 days before retraction
Rhodium(II) Proximity‐Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti‐Leukemia Activity
Matthew B. Minus, Wei Liu, Farrukh Vohidov et al. (12 authors)
Angewandte Chemie International Edition
Open Access
Published: Sep 2015
33 citations
33 citations
2934 days before retraction
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors
Jean‐René Pallandre, Christophe Borg, Didier Rognan et al. (8 authors)
European Journal of Medicinal Chemistry
Published: Sep 2015
34 citations
34 citations
2940 days before retraction
Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach
Giulio Poli, Arianna Gelain, Federica Porta et al. (6 authors)
Journal of Enzyme Inhibition and Medicinal Chemistry
Open Access
Published: Aug 2015
36 citations
36 citations
2948 days before retraction
Dual-inhibitors of STAT5 and STAT3: studies from molecular docking and molecular dynamics simulations
Shengjuan Shao, Rilei Yu, Yanqing Yu et al. (4 authors)
Journal of Molecular Modeling
Published: Aug 2014
15 citations
15 citations
3336 days before retraction
Small Molecule Inhibitors of Stat3 Protein as Cancer Therapeutic Agents
Brent D. G. Page
Unknown Journal
Published: Jun 2014
3379 days before retraction
Comparative screening and validation as a novel tool to identify STAT-specific inhibitors
Małgorzata Szeląg, Anna Czerwoniec, Joanna Wesoły et al. (4 authors)
European Journal of Pharmacology
Published: Jun 2014
9 citations
9 citations
3395 days before retraction
Computer-aided design and discovery of protein–protein interaction inhibitors as agents for anti-HIV therapy
A. V. Veselovsky, M. S. Zharkova, Vladimir Poroikov et al. (4 authors)
SAR and QSAR in environmental research
Published: Apr 2014
23 citations
23 citations
3450 days before retraction
Electrochemical detection of the Fc-STAT3 phosphorylation and STAT3–Fc-STAT3 dimerization and inhibition
Sanela Martić, Meghan K. Rains, Sina Haftchenary et al. (8 authors)
Molecular BioSystems
Published: Dec 2013
5 citations
5 citations
3567 days before retraction
Synthesis and biological evaluation of tetrahydropyridinepyrazoles (‘PFPs’) as inhibitors of STAT3 phosphorylation
Revanna C. N, Basappa Basappa, Vanita Srinivasa et al. (12 authors)
MedChemComm
Published: Oct 2013
9 citations
9 citations
3611 days before retraction
Activation of STAT3 in Human Gastric Cancer Cells via Interleukin (IL)-6-Type Cytokine Signaling Correlates with Clinical Implications
Zhengguang Wang, Xiulian Si, Aman Xu et al. (10 authors)
PLoS ONE
Open Access
Published: Oct 2013
75 citations
75 citations
3634 days before retraction
Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma
Brent D. G. Page, Danielle Croucher, Zhihua Li et al. (13 authors)
Journal of Medicinal Chemistry
Published: Aug 2013
35 citations
35 citations
3680 days before retraction
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells
Vijay Shahani, Daniel P. Ball, Allan V. Ramos et al. (9 authors)
Bioorganic & Medicinal Chemistry
Published: May 2013
9 citations
9 citations
3785 days before retraction
Progress towards the development of SH2 domain inhibitors
Dziyana Kraskouskaya, Eugenia Duodu, Carolynn C. Arpin et al. (4 authors)
Chemical Society Reviews
Published: Jan 2013
110 citations
110 citations
3913 days before retraction
Development of new N-arylbenzamides as STAT3 dimerization inhibitors
Murali K. Urlam, Roberta Pireddu, Yiyu Ge et al. (9 authors)
MedChemComm
Open Access
Published: Jan 2013
21 citations
21 citations
3913 days before retraction
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain
John S. McMurray, Pijus K. Mandal, Warren S.‐L. Liao et al. (5 authors)
JAK-STAT
Open Access
Published: Oct 2012
23 citations
23 citations
4005 days before retraction
Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
Pijus K. Mandal, Zhiyong Ren, Xiaohong Chen et al. (6 authors)
International Journal of Peptide Research and Therapeutics
Open Access
Published: Jul 2012
16 citations
16 citations
4091 days before retraction
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.
Edmond J. Auzenne, Jim Klostergaard, Pijus K. Mandal et al. (9 authors)
PubMed
Published: Jan 2012
36 citations
36 citations
4279 days before retraction
Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions
Jeremy L. Yap, Jay Chauhan, Kwan‐Young Jung et al. (6 authors)
MedChemComm
Published: Jan 2012
29 citations
29 citations
4279 days before retraction
The Jak-STAT Signal Transduction Pathway in Melanoma
Courtney Nicholas, Bernard Gregory
InTech eBooks
Open Access
Published: Jun 2011
15 citations
15 citations
4464 days before retraction
STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment
Antonio Lavecchia, Carmen Di Giovanni, Ettore Novellino
Current Medicinal Chemistry
Published: May 2011
69 citations
69 citations
4495 days before retraction
Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
Steven Fletcher, Brent D. G. Page, Xiaolei Zhang et al. (12 authors)
ChemMedChem
Open Access
Published: May 2011
51 citations
51 citations
4500 days before retraction
Signal Transducer and Activator of Transcription 3 (STAT3): A Promising Target for Anticancer Therapy
D. Masciocchi, Arianna Gelain, Stefania Villa et al. (5 authors)
Future Medicinal Chemistry
Published: Apr 2011
76 citations
76 citations
4554 days before retraction
Quick Stats
Total Citations:
39
Years Since Retraction:
2.2 years
Open Access:
Yes
Last Checked:
Jul 24, 2025