Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study

Institutions:

• Department of Internal Medicine, Fukushima Red Cross Hospital
• Department of Rheumatology, Hikarigaoka Spellman Hospital
• Munakata Yasuhiko Clinic
• Department of Rheumatology, Tsugaru General Hospital
• Suminoya Rheumatism & Orthopedics Clinic
• Department Orthopedic Surgery, Tohoku Rosai Hospital
• Yoshida Orthopedic Surgery and Rheumatology Clinic
• Center for Arthritis and Rheumatic Diseases, Tohoku Pharmaceutical University Hospital
• Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University
• Department of Orthopedic Surgery, Tohoku Orthopedic Clinic
• Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
• Nakazawa Sports Clinic
• Department of Rheumatology, Aomori Prefectural Central Hospital
• Department of Orthopedics, General Hanamaki Hospital
• Department of Rheumatology, Ohta Nishinouchi Hospital
• Komagamine Orthopedic and Rheumatology Clinic
• Yu Family Clinic
• Department of Internal Medicine, Ogachi Central Hospital
• Department of Rheumatology and Department of Orthopedic Surgery, Hoshi General Hospital
• Murai Clinic
• Department of Orthopedic Surgery, Yamagata University Faculty of Medicine
• Department of Orthopedic Surgery, Hirosaki Memorial Hospital
• Department of Rheumatology, Kaiyama Central Hospital
• Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine
• Department of Public Health and Hygiene/Nephrology and Collagen Disease
• Department of Internal Medicine, Morioka National Hospital
• Muryoi Clinic
• Minami-Fukushima Clinic
• NTT East Tohoku Hospital
• Ogura Orthopedic Surgery Clinic
• Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
• Department of Rheumatology and Collagen Disease, Fukushima Medical University Hospital
• Department of Internal Medicine, Saiseikai Yamagata Hospital
• Department of Internal Medicine, Yuri Kumiai General Hospital
• Izumi Himawari Clinic
• Department of Internal Medicine, Nihonkai General Hospital
• Department of Orthopedic Surgery, Wakuya-Town National Health Insurance Hospital
• Department of Orthopedic Surgery, Tohoku University Graduate School of Medicine