Retraction
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth
Paper Information
Record ID:
53227
Author(s):
Journal:
Publication Date:
January 18, 2016
Retraction Date:
April 22, 2024
(1.6 year years ago)
Subjects:
Institutions:
- Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, USA
- Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois, USA
- Department of Biology and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, Shenzhen, China
- Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USA
- Departments of Orthopedic Surgery & Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA
- Novozymes Biopharma US, Franklinton, North Carolina, USA
- Alomone Labs Ltd, Jerusalem, Israel
- Department of Internal Medicine (Section of Rheumatology), Rush University Medical Center, Chicago, Illinois, USA
- Department of Bioengineering, University of Illinois at Chicago, Illinois, USA
- Jesse Brown Veterans Affairs Medical Center at Chicago, Illinois, USA
Countries:
Article Type:
Publisher:
BMJ Publishing
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
Nature of Retraction:
Retraction
Retraction Notice:
10.1136/annrheumdis-2015-208444retAdditional Notes:
See also: https://pubpeer.com/publications/AF151687718F32174F99039FF4CB4A; see also https://www.federalregister.gov/documents/2023/11/03/2023-24342/findings-of-research-misconduct
Citations (51)
51
Total Citations3
Post-Retraction(5.9%)
48
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
2
Within 1 year
0
After 2+ years
456
Days since retraction (latest)
PTHrP buffers Wnt/β-catenin activity through a PKC-ζ involved negative feedback loop to maintain articular cartilage homeostasis and attenuate osteoarthritis
Wenxue Tong, H.J. Chen, Zi Ling Huang et al. (5 authors)
Journal of Orthopaedic Translation
Published: Jul 2025
456 days after retraction
Neurobiological Correlates of Rheumatoid Arthritis and Osteoarthritis: Remodelling and Plasticity of Nociceptive and Autonomic Innervations in Synovial Joints
Sharon Mathew, Sadaf Ashraf, Susan Shorter et al. (6 authors)
The Neuroscientist
Published: Dec 2024
1 citation
1 citation
234 days after retraction
β-hydroxybutyrate ameliorates osteoarthritis through activation of the ERBB3 signaling pathway in mice
Zhiqing Cai, Zhimin Zhang, Jiarong Leng et al. (12 authors)
Journal of Bone and Mineral Research
Published: Nov 2024
4 citations
4 citations
197 days after retraction
Skeletal interoception in osteoarthritis
Dinglong Yang, Jiawen Xu, Ke Xu et al. (4 authors)
Bone Research
Open Access
Published: Apr 2024
14 citations
14 citations
21 days before retraction
NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats
Zixiu Liu, Mingchao Li, Li Zhang et al. (8 authors)
Pain Research and Management
Open Access
Published: Feb 2024
7 citations
7 citations
63 days before retraction
Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model
Gurjit Singh, InSug O‐Sullivan, Arivarasu Natarajan Anbazhagan et al. (13 authors)
Gene
Published: Oct 2023
1 citation
1 citation
180 days before retraction
Anti-NGF treatment worsens subchondral bone and cartilage measures while improving symptoms in floor-housed rabbits with osteoarthritis
Stephanie Menges, M. Michaelis, Kerstin Kleinschmidt‐Dörr
Frontiers in Physiology
Open Access
Published: Jun 2023
10 citations
10 citations
301 days before retraction
Small molecule inhibitors of osteoarthritis: Current development and future perspective
Dan Liu, Xingxing Li, Lin Zhang et al. (7 authors)
Frontiers in Physiology
Open Access
Published: Apr 2023
7 citations
7 citations
381 days before retraction
miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction
Ke Lu, Qingyun Wang, Liu‐Zhi Hao et al. (10 authors)
Bioactive Materials
Open Access
Published: Mar 2023
24 citations
24 citations
399 days before retraction
Targeting Vascular Endothelial Growth Factor Receptors as a Therapeutic Strategy for Osteoarthritis and Associated Pain
Kaige Ma, Gurjit Singh, Jun Wang et al. (9 authors)
International Journal of Biological Sciences
Open Access
Published: Jan 2023
18 citations
18 citations
477 days before retraction
PTHrP buffers Wnt/β-catenin activity through a negative feedback loop to maintain articular cartilage homeostasis
Wenxue Tong, Jiankun Xu, Qiuli Qi et al. (12 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Nov 2022
514 days before retraction
Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization
InSug O‐Sullivan, Ranjan Kc, Gurjit Singh et al. (12 authors)
International Journal of Molecular Sciences
Open Access
Published: Oct 2022
16 citations
16 citations
559 days before retraction
Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis
Tae‐Hwan Gil, Haiyan Zheng, Hyo Gyeong Lee et al. (7 authors)
Aging
Open Access
Published: Aug 2022
29 citations
29 citations
621 days before retraction
Mechanisms of bone pain: Progress in research from bench to bedside
Gehua Zhen, Yuhan Fu, Chi Zhang et al. (10 authors)
Bone Research
Open Access
Published: Jun 2022
39 citations
39 citations
686 days before retraction
Osteoarthritis Pain
Huan Yu, Tianwen Huang, William W. Lu et al. (5 authors)
International Journal of Molecular Sciences
Open Access
Published: Apr 2022
98 citations
98 citations
731 days before retraction
Rodent models of knee osteoarthritis for pain research
Marta Alves-Simões
Osteoarthritis and Cartilage
Published: Feb 2022
35 citations
35 citations
806 days before retraction
Fibroblasts: the neglected cell type in peripheral sensitisation and chronic pain? A review based on a systematic search of the literature
Naomi Shinotsuka, Franziska Denk
BMJ Open Science
Open Access
Published: Jan 2022
16 citations
16 citations
842 days before retraction
Monoclonal Antibodies for Chronic Pain Treatment: Present and Future
Eva Sánchez-Robles, Rocı́o Girón, Nancy Paniagua et al. (6 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2021
32 citations
32 citations
940 days before retraction
Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies
Yvonne D’Arcy, Patrick W. Mantyh, Tony L. Yaksh et al. (7 authors)
Postgraduate Medicine
Open Access
Published: Jul 2021
54 citations
54 citations
1015 days before retraction
Nerve Growth Factor-Targeted Molecular Theranostics Based on Molybdenum Disulfide Nanosheet-Coated Gold Nanorods (MoS<sub>2</sub>-AuNR) for Osteoarthritis Pain
Man Ting Au, Jingyu Shi, Yadi Fan et al. (6 authors)
ACS Nano
Open Access
Published: Jul 2021
58 citations
58 citations
1026 days before retraction
Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy
Xu Li, Bingyang Dai, Jiaxin Guo et al. (8 authors)
Nano-Micro Letters
Open Access
Published: Jun 2021
109 citations
109 citations
1034 days before retraction
The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain
Sabrina Bimonte, Marco Cascella, Cira Antonietta Forte et al. (5 authors)
Journal of Pain Research
Open Access
Published: Jun 2021
25 citations
25 citations
1056 days before retraction
Inflammation, angiogenesis and sensory nerve sprouting in the synovium of bony ankylosed and not bony ankylosed knees with end‐stage haemophilic arthropathy
Jiaxin Huang, Haijia Zhu, Shuaijie Lv et al. (6 authors)
Haemophilia
Published: May 2021
6 citations
6 citations
1066 days before retraction
Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development
Xiwei Fan, Xiaoxin Wu, Ross Crawford et al. (5 authors)
Frontiers in Cell and Developmental Biology
Open Access
Published: May 2021
36 citations
36 citations
1078 days before retraction
Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
Qi Sun, Gehua Zhen, Tuo Peter Li et al. (14 authors)
eLife
Open Access
Published: Mar 2021
53 citations
53 citations
1148 days before retraction
Fibroblasts – the neglected cell type in peripheral sensitization and chronic pain? - A systematic view on the current state of the literature
Naomi Shinotsuka, Franziska Denk
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Feb 2021
1 citation
1 citation
1157 days before retraction
Animal models of pain: Diversity and benefits
Cynthia Abboud, Alexia Duveau, Rabia Bouali‐Benazzouz et al. (10 authors)
Journal of Neuroscience Methods
Open Access
Published: Nov 2020
85 citations
85 citations
1258 days before retraction
Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2/CCR2 signaling pathway
Bocun Li, Li Jing, Jia Li et al. (8 authors)
Experimental Biology and Medicine
Open Access
Published: Sep 2020
22 citations
22 citations
1328 days before retraction
Peripheral pain mechanisms in osteoarthritis
Tonia L. Vincent
Pain
Open Access
Published: Aug 2020
105 citations
105 citations
1346 days before retraction
Mesenchymal Stem Cell‐Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis
Young Guk Kim, Jonghoon Choi, Kyobum Kim
Biotechnology Journal
Published: Jun 2020
137 citations
137 citations
1403 days before retraction
Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis
Jianxi Zhu, Gehua Zhen, Senbo An et al. (11 authors)
eLife
Open Access
Published: May 2020
49 citations
49 citations
1431 days before retraction
Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models
Jeong-Im Hong, In Young Park, Hyun Ah Kim
International Journal of Molecular Sciences
Open Access
Published: Jan 2020
51 citations
51 citations
1560 days before retraction
Absence of VEGFR‐1/Flt‐1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model
Sujun Qiu, Changgui Shi, Arivarasu Natarajan Anbazhagan et al. (16 authors)
Journal of Cellular Physiology
Open Access
Published: Dec 2019
23 citations
23 citations
1580 days before retraction
Role of NGF‐TrkA signaling in calcification of articular chondrocytes
Yangzi Jiang, Rocky S. Tuan
The FASEB Journal
Open Access
Published: Jun 2019
29 citations
29 citations
1763 days before retraction
Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety
Martin Schmelz, Patrick W. Mantyh, Anne‐Marie Malfait et al. (7 authors)
Pain
Open Access
Published: May 2019
106 citations
106 citations
1797 days before retraction
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors
Yusuke Sakurai, Masahide Fujita, Shiori Kawasaki et al. (13 authors)
Pain
Published: Dec 2018
73 citations
73 citations
1950 days before retraction
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Shouan Zhu, Jianxi Zhu, Gehua Zhen et al. (28 authors)
Journal of Clinical Investigation
Open Access
Published: Dec 2018
360 citations
360 citations
1959 days before retraction
Anti‐nerve growth factor monoclonal antibodies for the control of pain in dogs and cats
Masataka Enomoto, Patrick W. Mantyh, Joanna C. Murrell et al. (5 authors)
Veterinary Record
Open Access
Published: Oct 2018
96 citations
96 citations
2004 days before retraction
Synovial nerve fiber density decreases with naturally-occurring osteoarthritis in horses
Raymond Pujol, Christiane Girard, Hélène Richard et al. (8 authors)
Osteoarthritis and Cartilage
Open Access
Published: Jun 2018
18 citations
18 citations
2127 days before retraction
Blockade of vascular endothelial growth factor receptor-1 (Flt-1), reveals a novel analgesic for osteoarthritis-induced joint pain
Vaskar Das, Ranjan Kc, Xin Li et al. (12 authors)
Gene Reports
Open Access
Published: Mar 2018
21 citations
21 citations
2237 days before retraction
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis
Mikie Hinata, Sunao Imai, Takao Sanaki et al. (19 authors)
Pain
Published: Feb 2018
29 citations
29 citations
2264 days before retraction
Molecular Mediators of Acute and Chronic Itch in Mouse and Human Sensory Neurons
Manouela V. Valtcheva
Unknown Journal
Published: Jan 2018
2303 days before retraction
Traumatic osteoarthritis-induced persistent mechanical hyperalgesia in a rat model of anterior cruciate ligament transection plus a medial meniscectomy
Hsiao-Chien Tsai, Ta-Liang Chen, Yu‐Pin Chen et al. (4 authors)
Journal of Pain Research
Open Access
Published: Dec 2017
20 citations
20 citations
2334 days before retraction
Nerve growth factor inhibitor with novel‐binding domain demonstrates nanomolar efficacy in both cell‐based and cell‐free assay systems
Allison E. Kennedy, Corey A. Laamanen, Mitchell S. Ross et al. (7 authors)
Pharmacology Research & Perspectives
Open Access
Published: Aug 2017
7 citations
7 citations
2433 days before retraction
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Di Chen, Jie Shen, Weiwei Zhao et al. (7 authors)
Bone Research
Open Access
Published: Jan 2017
1045 citations
1045 citations
2652 days before retraction
Osteoarthritis year in review 2016: biology
E.N. Blaney Davidson, A. van Caam, P.M. van der Kraan
Osteoarthritis and Cartilage
Open Access
Published: Jan 2017
46 citations
46 citations
2654 days before retraction
Pro- and Anti-inflammatory Cytokine Profiles in Osteoarthritis
Y.M. Bastiaansen-Jenniskens, Daniël B.F. Saris, Laura B. Creemers
Cartilage
Published: Jan 2017
5 citations
5 citations
2668 days before retraction
The use of surface plasmon resonance spectroscopy in characterizing small molecule-based nerve growth factor inhibitors
Allison E. Kennedy
Unknown Journal
Published: Nov 2016
2721 days before retraction
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis
Augustin Latourte, C. Cherifi, Jérémy Maillet et al. (9 authors)
Annals of the Rheumatic Diseases
Published: Oct 2016
304 citations
304 citations
2734 days before retraction
Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?
Rachel E. Miller, Joel A. Block, Anne‐Marie Malfait
Current Opinion in Rheumatology
Open Access
Published: Sep 2016
66 citations
66 citations
2764 days before retraction
Quick Stats
Total Citations:
51
Years Since Retraction:
1.6 year
Open Access:
Yes
Last Checked:
Jul 24, 2025