Retraction
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease
Paper Information
Record ID:
53295
Journal:
Publication Date:
May 09, 2012
Retraction Date:
March 28, 2024
(1.6 year years ago)
Subjects:
Specific Fields:
Genetics Neuroscience Medicine - Neurology Medicine - Pathology Medicine - Psychiatry
Genetics Neuroscience Medicine - Neurology Medicine - Pathology Medicine - Psychiatry
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Wiley
Open Access:
Yes
DOI:
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
Nature of Retraction:
Retraction
Retraction Notice:
10.1002/ana.26938Additional Notes:
See also: https://pubpeer.com/publications/686C000E68AD33C5D34FAFFD8C645C
Citations (76)
76
Total Citations0
Post-Retraction76
Pre-Retraction0
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Published: Feb 2024
1 citation
1 citation
44 days before retraction
Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation
Izhar Livne‐Bar, Shubham Maurya, Karsten Gronert et al. (4 authors)
Journal of Neuroinflammation
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4 citations
4 citations
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Molecular mechanism and potential therapeutic targets of necroptosis and ferroptosis in Alzheimer's disease
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Biomedicine & Pharmacotherapy
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19 citations
19 citations
166 days before retraction
The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strain
Sheng Tian, Tianyuan Ye, Xiaorui Cheng
Experimental Neurology
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Published: Aug 2023
8 citations
8 citations
223 days before retraction
Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
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Pharmaceuticals
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18 citations
18 citations
335 days before retraction
The genetics of phospholipase A2 induced redox signaling in neuroinflammation and neuronal diseases
Amit K. Maiti
Elsevier eBooks
Published: Jan 2023
452 days before retraction
Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer’s Disease
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International Journal of Molecular Sciences
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Published: Sep 2022
10 citations
10 citations
550 days before retraction
Frontotemporal lobar degeneration
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Elsevier eBooks
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1 citation
677 days before retraction
Leukotriene Signaling as a Target in α-Synucleinopathies
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Biomolecules
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Published: Feb 2022
10 citations
10 citations
764 days before retraction
Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
Chun Chen, Jianming Liao, Yiyuan Xia et al. (10 authors)
Gut
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Published: Jan 2022
300 citations
300 citations
807 days before retraction
Interrelationship between the 5-lipoxygenase pathway and microbial dysbiosis in the progression of Alzheimer's disease
Steven Mathis, Sobha R. Bodduluri, Bodduluri Haribabu
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Published: May 2021
5 citations
5 citations
1034 days before retraction
5-Lipoxygenase as an emerging target against age-related brain disorders
Mengdie Yan, Siran Zhang, Cheng-Tan Li et al. (8 authors)
Ageing Research Reviews
Published: May 2021
22 citations
22 citations
1053 days before retraction
Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease
Mayara dos Santos Maia, Gabriela Cristina Soares Rodrigues, Natália Ferreira de Sousa et al. (6 authors)
Oxidative Medicine and Cellular Longevity
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Published: Aug 2020
23 citations
23 citations
1319 days before retraction
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation
Zonglin He, Tao Di, Jiaming Xiong et al. (9 authors)
Neurochemical Research
Published: Jul 2020
17 citations
17 citations
1352 days before retraction
Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease
Rakesh Kumar Singh
Neurological Sciences
Published: Apr 2020
13 citations
13 citations
1445 days before retraction
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
Julia Marschallinger, Barbara Altendorfer, Edward Rockenstein et al. (16 authors)
Neurotherapeutics
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Published: Feb 2020
28 citations
28 citations
1500 days before retraction
Recent Trends in the Management of Alzheimer’s Disease: Current Therapeutic Options and Drug Repurposing Approaches
Rakesh Kumar Singh
Current Neuropharmacology
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Published: Jan 2020
24 citations
24 citations
1521 days before retraction
Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer’s disease mouse model promotes synaptic resilience
Krystyn Z. Bourne, Chandramouli Natarajan, Carlos Perez et al. (6 authors)
Scientific Reports
Open Access
Published: Dec 2019
10 citations
10 citations
1576 days before retraction
Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration
Changmo Kim, Izhar Livne‐Bar, Karsten Gronert et al. (4 authors)
Molecular Nutrition & Food Research
Open Access
Published: Dec 2019
17 citations
17 citations
1576 days before retraction
Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death
Qianyi Sun, Hong‐Hao Zhou, Xiao‐Yuan Mao
Oxidative Medicine and Cellular Longevity
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Published: Nov 2019
133 citations
133 citations
1581 days before retraction
Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach
Atukuri Dorababu
Bioorganic Chemistry
Published: Sep 2019
25 citations
25 citations
1652 days before retraction
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar et al. (10 authors)
Nature Communications
Open Access
Published: Aug 2019
276 citations
276 citations
1673 days before retraction
Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease
Jessica L. Hoffman, Sara Faccidomo, Michelle Kim et al. (9 authors)
bioRxiv (Cold Spring Harbor Laboratory)
Open Access
Published: Aug 2019
7 citations
7 citations
1696 days before retraction
Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia
Joanna Perła‐Kaján, Hieronim Jakubowski
International Journal of Molecular Sciences
Open Access
Published: Jun 2019
82 citations
82 citations
1736 days before retraction
Boswellia serrata Oleo-Gum-Resin and its Effect on Memory Functions: A Review
Mohaddese Mahboubi, Leila Mohammad Taghizadeh Kashani
The Natural Products Journal
Published: Mar 2019
1 citation
1 citation
1840 days before retraction
RETRACTED ARTICLE: Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35
Jianguo Li, Jin Chiu, Domenico Praticò
Molecular Psychiatry
Open Access
Published: Feb 2019
51 citations
51 citations
1876 days before retraction
New flavonoid – <i>N</i>,<i>N</i>-dibenzyl(<i>N</i>-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Martín Estrada, Clara Herrera‐Arozamena, Concepción Pérez et al. (11 authors)
Journal of Enzyme Inhibition and Medicinal Chemistry
Open Access
Published: Jan 2019
34 citations
34 citations
1913 days before retraction
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
Jessica L. Hoffman, Sara Faccidomo, Michelle Kim et al. (9 authors)
International review of neurobiology
Open Access
Published: Jan 2019
89 citations
89 citations
1913 days before retraction
Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats
Peng Zeng, Yan Shi, Xiaoming Wang et al. (12 authors)
The International Journal of Neuropsychopharmacology
Open Access
Published: Nov 2018
60 citations
60 citations
1971 days before retraction
Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer’s disease mouse model with plaques, tangles, and memory impairments
Jianguo Li, Jin Chu, Domenico Praticò
Molecular Psychiatry
Published: Oct 2018
20 citations
20 citations
2004 days before retraction
The leukotriene signaling pathway: a druggable target in Alzheimer’s disease
Johanna Michael, Julia Marschallinger, Ludwig Aigner
Drug Discovery Today
Open Access
Published: Sep 2018
57 citations
57 citations
2018 days before retraction
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Martín Estrada, Clara Herrera‐Arozamena, Lucía de Andrés et al. (13 authors)
European Journal of Medicinal Chemistry
Open Access
Published: Jul 2018
49 citations
49 citations
2087 days before retraction
Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase
Elisabetta Lauretti, Domenico Praticò
Journal of Alzheimer s Disease
Open Access
Published: May 2018
9 citations
9 citations
2148 days before retraction
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy
Antonio Di Meco, Jianguo Li, Carlos A. Barrero et al. (5 authors)
Molecular Psychiatry
Open Access
Published: Apr 2018
29 citations
29 citations
2159 days before retraction
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
Phillip F. Giannopoulos, Jian Chiu, Domenico Praticò
Aging Cell
Open Access
Published: Apr 2018
17 citations
17 citations
2188 days before retraction
The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Translational Psychiatry
Open Access
Published: Dec 2017
30 citations
30 citations
2295 days before retraction
RETRACTED ARTICLE: Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
Phillip F. Giannopoulos, Domenico Praticò
Molecular Neurobiology
Published: Nov 2017
15 citations
15 citations
2329 days before retraction
Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Aging Cell
Open Access
Published: Nov 2017
35 citations
35 citations
2336 days before retraction
Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases
Anne‐Sophie Cornec, Ludovica Monti, Jane Kovalevich et al. (13 authors)
Journal of Medicinal Chemistry
Open Access
Published: May 2017
46 citations
46 citations
2502 days before retraction
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
Jianguo Li, Carlos A. Barrero, Salim Merali et al. (4 authors)
Scientific Reports
Open Access
Published: Apr 2017
28 citations
28 citations
2548 days before retraction
Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease
Jin Chu, Elisabetta Lauretti, Domenico Praticò
Molecular Psychiatry
Published: Jan 2017
82 citations
82 citations
2613 days before retraction
The retromer complex system in a transgenic mouse model of AD: influence of age
Jin Chu, Domenico Praticò
Neurobiology of Aging
Published: Jan 2017
30 citations
30 citations
2640 days before retraction
Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases
Paolo Gelosa, Francesca Colazzo, Elena Tremoli et al. (5 authors)
Mediators of Inflammation
Open Access
Published: Jan 2017
57 citations
57 citations
2643 days before retraction
Homocysteine modulates 5-lipoxygenase expression level via DNA methylation
Li Jianguo, Carlos A. Barrero, Sapna Gupta et al. (6 authors)
Aging Cell
Open Access
Published: Nov 2016
44 citations
44 citations
2676 days before retraction
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms
Rubén Corpas, Susana Revilla, Suzanna Ursulet et al. (10 authors)
Molecular Neurobiology
Published: Sep 2016
107 citations
107 citations
2756 days before retraction
Combined Administration of Melissa officinalis and Boswellia serrata Extracts in an Animal Model of Memory
Mohaddese Mahboubi, Mohsen Taghizadeh, Sayyed Alireza Talaei et al. (6 authors)
Iranian Journal of Psychiatry and Behavioral Sciences
Open Access
Published: Aug 2016
39 citations
39 citations
2782 days before retraction
The 5-Lipoxygenase as modulator of Alzheimer’s γ-secretase and therapeutic target
Jin Chu, Domenico Praticò
Brain Research Bulletin
Open Access
Published: Mar 2016
34 citations
34 citations
2931 days before retraction
N-3 PUFAs and neuroinflammatory processes in cognitive disorders
Quentin Leyrolle, Sophie Layé, Agnès Nadjar
OCL
Open Access
Published: Jan 2016
1 citation
1 citation
3009 days before retraction
The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
Grzegorz A. Czapski, Kinga Czubowicz, Joanna B. Strosznajder et al. (4 authors)
Neurochemical Research
Open Access
Published: Dec 2015
116 citations
116 citations
3025 days before retraction
Gene Therapy Models of Alzheimer’s Disease and Other Dementias
Benjamin Combs, Andrew Kneynsberg, Nicholas M. Kanaan
Methods in molecular biology
Open Access
Published: Nov 2015
30 citations
30 citations
3045 days before retraction
Quick Stats
Total Citations:
76
Years Since Retraction:
1.6 year
Open Access:
Yes
Last Checked:
Jul 24, 2025