Retraction
Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury
Paper Information
Record ID:
53315
Author(s):
Journal:
Publication Date:
September 10, 2017
Retraction Date:
November 25, 2023
(2.0 year years ago)
Subjects:
Institutions:
Country:
🇨🇳 ChinaArticle Type:
Publisher:
Elsevier
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
- Euphemisms for Plagiarism
- Falsification/Fabrication of Image
- Investigation by Company/Institution
- Investigation by Journal/Publisher
- Investigation by Third Party
- Misconduct - Official Investigation(s) and/or Finding(s)
- Original Data and/or Images not Provided and/or not Available
- Plagiarism of Image
- Unreliable Image
- Unreliable Results and/or Conclusions
Nature of Retraction:
Retraction
Retraction Notice:
10.1016/j.biopha.2023.115945Additional Notes:
Investigation findings: https://www.nsfc.gov.cn/publish/portal0/table442/info85495.htm See also: https://pubpeer.com/publications/7D9475A7397928053FFE9442F8E943
Citations (92)
92
Total Citations13
Post-Retraction(14.1%)
79
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
3
Within 30 days
10
Within 1 year
0
After 2+ years
459
Days since retraction (latest)
Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective
Heena Khan, Aditi Singh, Yashpal Singh et al. (7 authors)
Metabolic Brain Disease
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5 citations
5 citations
459 days after retraction
Microglial Autophagic Dysregulation in Traumatic Brain Injury: Molecular Insights and Therapeutic Avenues
Nargis Bano, Sameera Khan, Shakir Ahamad et al. (7 authors)
ACS Chemical Neuroscience
Published: Feb 2025
1 citation
1 citation
440 days after retraction
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Tomoyoshi Tamura, Changde Cheng, Ana B. Villaseñor-Altamirano et al. (37 authors)
Science Translational Medicine
Published: Dec 2024
375 days after retraction
Neuron-specific deficiency of autophagy increases neuronal loss in traumatic brain injury
Chunying Pei, Bo Li, Sijia Wen et al. (12 authors)
PNAS Nexus
Open Access
Published: Oct 2024
311 days after retraction
Dexmedetomidine Attenuates Hemodynamic and Proinflammatory Responses During Craniotomy for Traumatic Brain Injury
Liying Li, Yanxin Cheng, Zhao Guang-ping et al. (8 authors)
American Journal of Therapeutics
Published: Sep 2024
1 citation
1 citation
304 days after retraction
Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury
Seyedeh Parisa Navabi, Firuzeh Badreh, Maryam Khombi Shooshtari et al. (6 authors)
Heliyon
Open Access
Published: Aug 2024
5 citations
5 citations
250 days after retraction
Dexmedetomidine improves the circulatory dysfunction of the glymphatic system induced by sevoflurane through the PI3K/AKT/ΔFosB/AQP4 pathway in young mice
Shuying Wang, Xiaojin Yu, Lili Cheng et al. (14 authors)
Cell Death and Disease
Open Access
Published: Jun 2024
6 citations
6 citations
213 days after retraction
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
Nina Gu, Yan Jin, Wei Tang et al. (13 authors)
Journal of Neuroinflammation
Open Access
Published: Jun 2024
15 citations
15 citations
192 days after retraction
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury
Nina Gu, Yan Jin, Wei Tang et al. (13 authors)
Research Square (Research Square)
Open Access
Published: Feb 2024
68 days after retraction
Nicorandil attenuates cisplatin-induced acute kidney injury in rats via activation of PI3K/AKT/mTOR signaling cascade and inhibition of autophagy
Mohamed I. Fahmy, Samar S. Khalaf, Noha N. Yassen et al. (4 authors)
International Immunopharmacology
Published: Dec 2023
9 citations
9 citations
35 days after retraction
The neuroprotection of controlled decompression after traumatic epidural intracranial hypertension through suppression of autophagy via PI3K/Akt signaling pathway
Yuanyuan Che, Wei Wu, Xiao Qian et al. (8 authors)
Heliyon
Open Access
Published: Dec 2023
2 citations
2 citations
24 days after retraction
Future directions in ventilator-induced lung injury associated cognitive impairment: a new sight
Yinuo Liu, Xintong Cai, Ruiying Fang et al. (6 authors)
Frontiers in Physiology
Open Access
Published: Dec 2023
2 citations
2 citations
23 days after retraction
Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury through the GUO-PI3K/Akt signaling pathway
Nina Gu, Yan Jin, Wei Tang et al. (13 authors)
Research Square (Research Square)
Open Access
Published: Dec 2023
18 days after retraction
Inflammasome pathway in kidney transplantation
Simona Granata, Daniele La Russa, Giovanni Stallone et al. (5 authors)
Frontiers in Medicine
Open Access
Published: Nov 2023
5 citations
5 citations
17 days before retraction
Weight-drop model as a valuable tool to study potential neurobiological processes underlying behavioral and cognitive changes secondary to mild traumatic brain injury
Caroline Amaral Machado, Bruna da Silva Oliveira, Thomaz Lüscher Dias et al. (24 authors)
Journal of Neuroimmunology
Open Access
Published: Nov 2023
6 citations
6 citations
19 days before retraction
The effects of dexmedetomidine on trauma-induced secondary injury in rat brain
Ahmet Şen, Başar Erdivanlı, Levent Tümkaya et al. (7 authors)
Neurological Research
Open Access
Published: Oct 2023
40 days before retraction
Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic–ischemic neonatal rats
Xiaohong Chen, Andi Chen, Jianjie Wei et al. (14 authors)
CNS Neuroscience & Therapeutics
Open Access
Published: Oct 2023
32 citations
32 citations
43 days before retraction
HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice
Hongxia Xing, Shensen Li, Yongchao Fu et al. (11 authors)
Renal Failure
Open Access
Published: Aug 2023
4 citations
4 citations
107 days before retraction
Cenobamate (YKP3089) and Drug-Resistant Epilepsy: A Review of the Literature
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
Medicina
Open Access
Published: Jul 2023
16 citations
16 citations
120 days before retraction
The Role of Inhaled Estradiol and Myrtenol, Alone and in Combination, in Modulating Behavioral and Functional Outcomes Following Traumatic Experimental Brain Injury: Hemodynamic, Molecular, Histological and Behavioral Study
Mohammad Amin Rajizadeh, Mohammad Khaksari, Mohammad Abbas Bejeshk et al. (7 authors)
Neurocritical Care
Published: Apr 2023
13 citations
13 citations
213 days before retraction
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K/Akt/mTOR pathway
Jianli Li, Keyan Wang, Meinv Liu et al. (6 authors)
Journal of Molecular Histology
Published: Apr 2023
17 citations
17 citations
213 days before retraction
Second Generation of Antiepileptic Drugs and Oxidative Stress
Kamil Kośmider, Maciej Kamieniak, Stanisław J. Czuczwar et al. (4 authors)
International Journal of Molecular Sciences
Open Access
Published: Feb 2023
20 citations
20 citations
283 days before retraction
Are GABAergic drugs beneficial in providing neuroprotection after traumatic brain injuries? A comprehensive literature review of preclinical studies
Shyam Kumar Sudhakar
Frontiers in Neurology
Open Access
Published: Feb 2023
7 citations
7 citations
296 days before retraction
Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive
Annalisa Nobili, Livia La Barbera, Roberta Mastrantonio et al. (7 authors)
Contemporary clinical neuroscience
Published: Jan 2023
328 days before retraction
Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis
Sebastián Gatica, Cristobal Aravena, Yolanda Prado et al. (9 authors)
Advances in experimental medicine and biology
Published: Jan 2023
3 citations
3 citations
328 days before retraction
Electroacupuncture alleviates traumatic brain injury by inhibiting autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway in rats
Tao Wu, Jiushe Kou, Xuemei Li et al. (7 authors)
Metabolic Brain Disease
Published: Dec 2022
6 citations
6 citations
345 days before retraction
Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): Relevant signaling pathways and therapeutic strategies
Jing Jin, Ji’an Duan, Leiya Du et al. (6 authors)
Frontiers in Immunology
Open Access
Published: Nov 2022
76 citations
76 citations
367 days before retraction
Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side
Alice Jacquens, Edward Needham, Elisa R. Zanier et al. (6 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2022
37 citations
37 citations
428 days before retraction
The neuroprotective effect of dexmedetomidine and its mechanism
Yijun Hu, Hong Zhou, Huanxin Zhang et al. (10 authors)
Frontiers in Pharmacology
Open Access
Published: Sep 2022
60 citations
60 citations
431 days before retraction
Assessment of the effects of dexmedetomidine on outcomes of traumatic brain injury using propensity score analysis
Jinbu Xu, Qing Xiao
BMC Anesthesiology
Open Access
Published: Sep 2022
9 citations
9 citations
449 days before retraction
SLC26A4 Mutation Promotes Cell Apoptosis by Inducing Pendrin Transfer, Reducing Cl- Transport, and Inhibiting PI3K/Akt/mTOR Pathway
Xiang Dai, Jun Li, Xi‐Jiang Hu et al. (5 authors)
BioMed Research International
Open Access
Published: Aug 2022
6 citations
6 citations
453 days before retraction
Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy
Shankun Zhao, Weizhou Wu, Xuezheng Lin et al. (7 authors)
Cellular & Molecular Biology Letters
Open Access
Published: May 2022
26 citations
26 citations
570 days before retraction
Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Ahmad Movahedpour, Omid Vakili, Masoomeh Khalifeh et al. (12 authors)
Cell Biochemistry and Function
Published: Mar 2022
29 citations
29 citations
627 days before retraction
Protective role of wogonin following traumatic brain injury by reducing oxidative stress and apoptosis via the PI3K/Nrf2/HO‑1 pathway
Yan Feng, Yaru Ju, Zhongjie Yan et al. (8 authors)
International Journal of Molecular Medicine
Open Access
Published: Feb 2022
33 citations
33 citations
645 days before retraction
Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway
Xinjie Yang, Shizhang Ling, Meng‐Liang Zhou et al. (14 authors)
Neuroscience
Open Access
Published: Feb 2022
14 citations
14 citations
652 days before retraction
Traumatic brain injury and translational research: pharmacological and nonpharmacological perspectives
Denise Battaglini, Chiara Robba, Paolo Pelosi
Elsevier eBooks
Published: Jan 2022
693 days before retraction
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation
Yu Zhang, Qianbo Chen, Dashuang Chen et al. (8 authors)
CNS Neuroscience & Therapeutics
Open Access
Published: Dec 2021
52 citations
52 citations
713 days before retraction
Exosomes Derived from M2 Macrophages Exert a Therapeutic Effect via Inhibition of the PI3K/AKT/mTOR Pathway in Rats with Knee Osteoarthritic
Zha Xi Da-wa, Ma Jun, Liu Chao-zheng et al. (12 authors)
BioMed Research International
Open Access
Published: Dec 2021
36 citations
36 citations
715 days before retraction
MicroRNA-31 inhibits traumatic brain injury-triggered neuronal cell apoptosis by regulating hypoxia-inducible factor-1A/vascular endothelial growth factor A axis
Yan Qian, Xin Li, Raofei Fan et al. (9 authors)
Neuroreport
Published: Nov 2021
10 citations
10 citations
726 days before retraction
Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain Injury
Dicle Karakaya, Canan Cakir-Aktas, Şennur Uzun et al. (5 authors)
Neurocritical Care
Published: Nov 2021
14 citations
14 citations
739 days before retraction
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury
Xuejun He, Yimin Huang, Yanchao Liu et al. (15 authors)
International Journal of Molecular Medicine
Open Access
Published: Nov 2021
28 citations
28 citations
746 days before retraction
Deficiency in Androgen Receptor Aggravates Traumatic Brain Injury-Induced Pathophysiology and Motor Deficits in Mice
Yu‐Hsin Chen, Yen‐Chou Chen, Ling-Ling Hwang et al. (5 authors)
Molecules
Open Access
Published: Oct 2021
4 citations
4 citations
771 days before retraction
Dexmedetomidine regulates sevoflurane‐induced neurotoxicity through the miR‐330‐3p/ULK1 axis
Shan Xu, Ruyue Gao, Liang Chen
Journal of Biochemical and Molecular Toxicology
Published: Sep 2021
12 citations
12 citations
786 days before retraction
The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: Evidence from in vitro and in vivo studies
Kantarakorn Unchiti, Prangmalee Leurcharusmee, Artid Samerchua et al. (6 authors)
European Journal of Neuroscience
Published: Sep 2021
60 citations
60 citations
791 days before retraction
Targeting Abnormal PI3K/AKT/mTOR Signaling in Intracerebral Hemorrhage: A Systematic Review on Potential Drug Targets and Influences of Signaling Modulators on Other Neurological Disorders
Sidharth Mehan, Kuldeep Singh Jadaun, Aarti Sharma et al. (4 authors)
Current Reviews in Clinical and Experimental Pharmacology
Published: Jul 2021
15 citations
15 citations
851 days before retraction
The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
Zaara Liaquat, Xiaoying Xu, Prince Last Mudenda Zilundu et al. (5 authors)
Brain Sciences
Open Access
Published: Jun 2021
67 citations
67 citations
883 days before retraction
JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin Expression
Andrezza Bond Vieira Furtado, Débora Farina Gonçalves, Diane Duarte Hartmann et al. (12 authors)
Molecular Neurobiology
Published: Jun 2021
12 citations
12 citations
889 days before retraction
The Effects of Dexmedetomidine on Trauma-Induced Secondary Injury in Rat Brain
Ahmet Şen, Başar Erdivanlı, Levent Tümkaya et al. (7 authors)
Research Square (Research Square)
Open Access
Published: Jun 2021
893 days before retraction
Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets
Komal Thapa, Heena Khan, Thakur Gurjeet Singh et al. (4 authors)
Journal of Molecular Neuroscience
Published: May 2021
231 citations
231 citations
933 days before retraction
The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury
Yanna Li, Mingcui Qu, Fei Xing et al. (7 authors)
Journal of Cardiovascular Translational Research
Published: Apr 2021
14 citations
14 citations
940 days before retraction
Quick Stats
Total Citations:
92
Years Since Retraction:
2.0 year
Open Access:
Yes
Last Checked:
Jul 24, 2025