Retraction

Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury

Paper Information

Record ID:
53315
Author(s):
Min Shen
Shan Wang
Xin Wen
Xin Rui Han
Yong Jian Wang
Xiu Min Zhou
Man He Zhang
Dong Mei Wu
Jun Lu
Yuan Lin Zhang
Journal:
Biomedicine & Pharmacotherapy ( Elsevier )
Publication Date:
September 10, 2017
Retraction Date:
November 25, 2023 (2.0 year years ago)
Subjects:
Broad Categories:
Medicine Biology Genetics
Institutions:
Country:
🇨🇳 China
Article Type:
Clinical Study
Publisher:
Elsevier
Open Access:
Yes
DOI:
10.1016/j.biopha.2017.08.125
PubMed ID:
28903184
Retraction PubMed ID:
38008611

Retraction Details

Retraction Reasons:
Nature of Retraction:

Retraction

Retraction Notice:
10.1016/j.biopha.2023.115945
Additional Notes:

Investigation findings: https://www.nsfc.gov.cn/publish/portal0/table442/info85495.htm See also: https://pubpeer.com/publications/7D9475A7397928053FFE9442F8E943

Citations (92)

92
Total Citations
13
Post-Retraction
(14.1%)
79
Pre-Retraction
0
Same Day
Post-Retraction Citation Analysis
3 Within 30 days
10 Within 1 year
0 After 2+ years
459 Days since retraction (latest)
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Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex
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International Immunopharmacology
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iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment
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Molecular Brain Open Access
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1032 days before retraction
MicroRNA expression profiling after recurrent febrile seizures in rat and emerging role of miR-148a-3p/SYNJ1 axis
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Scientific Reports Open Access
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12 citations
1046 days before retraction
Dexmedetomidine post-conditioning ameliorates long-term neurological outcomes after neonatal hypoxic ischemia: The role of autophagy
Hang Xue, Ziyi Wu, Ying Xu et al. (7 authors)
Life Sciences
Published: Jan 2021
19 citations
1048 days before retraction
Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats
Xiaohui Chen, Dongtai Chen, Qiang Li et al. (8 authors)
Oxidative Medicine and Cellular Longevity Open Access
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30 citations
1058 days before retraction
Dexmedetomidine improves oxygen-glucose deprivation/reoxygenation (OGD/R) -induced neurological injury through regulating SNHG11/miR-324-3p/VEGFA axis
Yujie Chen, Zhiying Fan, Qingwei Wu
Bioengineered Open Access
Published: Jan 2021
27 citations
1058 days before retraction
Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug
Michał Wiciński, Oskar Puk, Bartosz Malinowski
Neurochemical Research
Published: Nov 2020
11 citations
1090 days before retraction
Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy
Zhibing Li, Guang‐Cai Li, Jing Qin
Archives of Medical Research
Published: Nov 2020
16 citations
1095 days before retraction
Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury
Hengchang Li, Chengxiang Lu, Wenfei Yao et al. (6 authors)
Aging Open Access
Published: Nov 2020
56 citations
1116 days before retraction
Dexmedetomidine inhibits the PSD95‑NMDA receptor interaction to promote functional recovery following traumatic brain injury
Zhongbai Zhao, Yu Ren, Hong Jiang et al. (4 authors)
Experimental and Therapeutic Medicine Open Access
Published: Nov 2020
15 citations
1118 days before retraction
RETRACTED: Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway
Ensheng Zhang, Qian Chen, Jing Wang et al. (6 authors)
International Immunopharmacology
Published: Jul 2020
15 citations
1239 days before retraction
Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury
Tianyuan Yang, Xiujing Feng, Yuan Zhao et al. (8 authors)
Frontiers in Pharmacology Open Access
Published: Jun 2020
57 citations
1249 days before retraction
Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages
Qingyuan Meng, Pinhao Guo, Zhengyu Jiang et al. (5 authors)
Aging Open Access
Published: May 2020
20 citations
1284 days before retraction
Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures
Volha Liaudanskaya, Joon Yong Chung, Craig Mizzoni et al. (11 authors)
Advanced Healthcare Materials Open Access
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34 citations
1291 days before retraction
Mechanisms of Dexmedetomidine in Neuropathic Pain
Yang Zhao, Jianshuai He, Ning Yu et al. (5 authors)
Frontiers in Neuroscience Open Access
Published: May 2020
99 citations
1299 days before retraction
Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia
Eric E. Abrahamson, Miloš D. Ikonomović
Experimental Neurology
Published: Feb 2020
74 citations
1373 days before retraction
Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway
Yejing Chai, Kangsheng Zhu, Chao Li et al. (7 authors)
Molecular Medicine Reports Open Access
Published: Jan 2020
18 citations
1401 days before retraction
Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury
Miaad Bader, Yazhou Li, David Tweedie et al. (11 authors)
Frontiers in Cell and Developmental Biology Open Access
Published: Jan 2020
39 citations
1415 days before retraction
The Application and Analytical Pathway of Dexmedetomidine in Ischemia/Reperfusion Injury
Ying Tang, Changxin Jia, Jianshuai He et al. (6 authors)
Journal of Analytical Methods in Chemistry Open Access
Published: Dec 2019
15 citations
1429 days before retraction
Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation
Nehal M. Elsherbiny, Yousra Abdel–Mottaleb, Amany Y. Elkazaz et al. (11 authors)
Frontiers in Neuroscience Open Access
Published: Nov 2019
34 citations
1485 days before retraction
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway
Nan Wang, Mingyu Wang
BMC Anesthesiology Open Access
Published: Jul 2019
42 citations
1582 days before retraction
Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation
Zhaohua Tian, Tang Cong-yao, Zhigang Wang
Journal of Cellular Biochemistry
Published: Jul 2019
48 citations
1607 days before retraction
<p>Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1</p>
Yonghong Tan, Xiaobao Bi, Qiong Wang et al. (7 authors)
Drug Design Development and Therapy Open Access
Published: Jul 2019
16 citations
1608 days before retraction
Traumatic Brain Injury Temporal Proteome Guides KCC2-Targeted Therapy
Pavel N. Lizhnyak, Pretal P. Muldoon, Pallavi P. Pilaka et al. (5 authors)
Journal of Neurotrauma Open Access
Published: May 2019
21 citations
1646 days before retraction
Sirt1 improves functional recovery by regulating autophagy of astrocyte and neuron after brain injury
Zhuo Zhang, Dan Li, Li Xu et al. (4 authors)
Brain Research Bulletin
Published: May 2019
25 citations
1654 days before retraction
Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics
Jina Ko, Matthew A. Hemphill, Zijian Yang et al. (12 authors)
Journal of Neurotrauma Open Access
Published: Apr 2019
67 citations
1695 days before retraction
Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5
Yueling Wang, Aijun Jia, Wenjuan Ma
Molecular Medicine Reports Open Access
Published: Nov 2018
22 citations
1825 days before retraction
Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1α signaling pathway
Fayin Li, Xiaodong Wang, Zhi-Kui Deng et al. (6 authors)
Neuropeptides Open Access
Published: Nov 2018
42 citations
1849 days before retraction
Glaucocalyxin B protects against oxygen‐glucose‐deprivation/reperfusion‐induced neuronal injury in PC‐12 cells
Yuxin Liu, Xianchuang Wu, Jihong An et al. (7 authors)
Journal of Cellular Biochemistry
Published: Oct 2018
14 citations
1872 days before retraction
Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1–Bax signaling
Yangyang Shan, Shiwei Sun, Fan Yang et al. (5 authors)
Drug Design Development and Therapy Open Access
Published: Oct 2018
47 citations
1881 days before retraction
Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats
Bin Zheng, Shuncai Zhang, Yan-Lu Ying et al. (7 authors)
Bioscience Reports Open Access
Published: Sep 2018
59 citations
1893 days before retraction
Dexmedetomidine restores autophagy and cardiac dysfunction in rats with streptozotocin-induced diabetes mellitus
Ju Eun Oh, Ji Hae Jun, Hye Jeong Hwang et al. (6 authors)
Acta Diabetologica
Published: Sep 2018
21 citations
1901 days before retraction
Branched-Chain Amino Acids Enhance Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Transection in Rats
Tao Wang, Xiao-Yan Wei, An-An Yang et al. (9 authors)
Current Eye Research
Published: Sep 2018
5 citations
1902 days before retraction
Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
Jiang Fang, Xue Wang, Jian Zhou et al. (8 authors)
Drug Design Development and Therapy Open Access
Published: Aug 2018
94 citations
1942 days before retraction
Neuroprotective effect of vildagliptin against cerebral ischemia in rats
Salma A. El‐Marasy, Rehab F. Abdel‐Rahman, Reham M. Abd‐Elsalam
Naunyn-Schmiedeberg s Archives of Pharmacology
Published: Jul 2018
48 citations
1956 days before retraction
Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
Li Zhang, Xue Wang
Frontiers in Molecular Neuroscience Open Access
Published: Jun 2018
75 citations
1999 days before retraction
Aβ1–42 oligomer induces alteration of tight junction scaffold proteins via RAGE-mediated autophagy in bEnd.3 cells
Yuanjin Chan, Wenjing Chen, Wenbin Wan et al. (6 authors)
Experimental Cell Research
Published: May 2018
38 citations
2006 days before retraction
Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism
Dongpei Yin, Shuai Zhou, Xin Xu et al. (14 authors)
Brain Research
Published: May 2018
64 citations
2009 days before retraction
Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression
Man‐He Zhang, Xiumin Zhou, Jianzhong Cui et al. (6 authors)
Molecular Medicine Reports Open Access
Published: Apr 2018
42 citations
2046 days before retraction
Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
Jianlei Zhao, George Li, Wenbi Xiong et al. (7 authors)
Evidence-based Complementary and Alternative Medicine Open Access
Published: Jan 2018
20 citations
2154 days before retraction
Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms
Ziwei Zhou, Jianning Zhang, Dong Wang et al. (6 authors)
Neural Regeneration Research Open Access
Published: Jan 2018
57 citations
2154 days before retraction
Quick Stats
Total Citations: 92
Years Since Retraction: 2.0 year
Open Access: Yes
Last Checked: Jul 24, 2025
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