Retraction

Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy

Paper Information

Record ID:
54406
Author(s):
Phillip F Giannopoulos
Jin Chu
Margaret Sperow
Jian Guo Li
W Haung Yu
Lynn G Kirby
Mary Abood
Domenico Praticò
Journal:
Biological Psychiatry ( Elsevier )
Publication Date:
February 06, 2015
Retraction Date:
July 15, 2024 (1.3 year years ago)
Subjects:
Broad Categories:
Neuroscience Toxicology Biochemistry
Institutions:
Country:
🇺🇸 United States
Article Type:
Research Article
Publisher:
Elsevier
Open Access:
Yes
DOI:
10.1016/j.biopsych.2015.01.015
PubMed ID:
25802082
Retraction PubMed ID:
38925714

Retraction Details

Retraction Reasons:
Nature of Retraction:

Retraction

Retraction Notice:
10.1016/j.biopsych.2024.05.002
Additional Notes:

See also: https://pubpeer.com/publications/DF7AB349A805675737F898FA6752A0

Citations (45)

45
Total Citations
2
Post-Retraction
(4.4%)
43
Pre-Retraction
0
Same Day
Post-Retraction Citation Analysis
1 Within 30 days
2 Within 1 year
0 After 2+ years
37 Days since retraction (latest)
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Retraction Note to: Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway
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Molecular Neurobiology Open Access
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18 days after retraction
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
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Signal Transduction and Targeted Therapy Open Access
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564 citations
297 days before retraction
Retraction Note to: Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
Phillip F. Giannopoulos, Domenico Praticò
Molecular Neurobiology Open Access
Published: Feb 2023
507 days before retraction
Mitochondria-targeted antioxidant SkQ1 inhibits leukotriene synthesis in human neutrophils
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599 days before retraction
Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling
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EBioMedicine Open Access
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24 citations
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Emerging Therapeutic Approaches for Neurodegenerative Diseases
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BENTHAM SCIENCE PUBLISHERS eBooks
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Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities
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Brain Behavior and Immunity
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16 citations
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Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives
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Frontiers in Molecular Neuroscience Open Access
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14 citations
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Interrelationship between the 5-lipoxygenase pathway and microbial dysbiosis in the progression of Alzheimer's disease
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The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
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International Journal of Molecular Sciences Open Access
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29 citations
1224 days before retraction
High ability of zileuton ((±)-1-(1-benzo[b]thien-2-ylethyl)-1-hydroxyurea) to stimulate IK(Ca) but suppress IK(DR) and IK(M) independently of 5-lipoxygenase inhibition
Te‐Yu Hung, Chin‐Wei Huang, Sheng‐Nan Wu
European Journal of Pharmacology
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7 citations
1433 days before retraction
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation
Zonglin He, Tao Di, Jiaming Xiong et al. (9 authors)
Neurochemical Research
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17 citations
1461 days before retraction
Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease
Rakesh Kumar Singh
Neurological Sciences
Published: Apr 2020
13 citations
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Recent Trends in the Management of Alzheimer’s Disease: Current Therapeutic Options and Drug Repurposing Approaches
Rakesh Kumar Singh
Current Neuropharmacology Open Access
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24 citations
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A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
Jianguo Li, Jin Chiu, Mercy Ramanjulu et al. (5 authors)
Molecular Neurodegeneration Open Access
Published: Jan 2020
74 citations
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Frontrunner in Translation: Progressive Supranuclear Palsy
Ali Shoeibi, Nahid Olfati, Irene Litvan
Frontiers in Neurology Open Access
Published: Oct 2019
28 citations
1728 days before retraction
Current and Emerging Pharmacological Targets for the Treatment of Alzheimer’s Disease
Ahmed Morsy, Paul C. Trippier
Journal of Alzheimer s Disease
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31 citations
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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar et al. (10 authors)
Nature Communications Open Access
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276 citations
1782 days before retraction
Intersection of pathological tau and microglia at the synapse
Thomas Vogels, Adriana‐Natalia Murgoci, Tomáš Hromádka
Acta Neuropathologica Communications Open Access
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160 citations
1837 days before retraction
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Rongcan Luo, Ling-Yan Su, Guiyu Li et al. (12 authors)
Autophagy Open Access
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296 citations
1942 days before retraction
RETRACTED ARTICLE: Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35
Jianguo Li, Jin Chiu, Domenico Praticò
Molecular Psychiatry Open Access
Published: Feb 2019
51 citations
1985 days before retraction
Lipidomics
Valeria Benedusi
Materials and Methods
Published: Nov 2018
3 citations
2069 days before retraction
Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer’s disease mouse model with plaques, tangles, and memory impairments
Jianguo Li, Jin Chu, Domenico Praticò
Molecular Psychiatry
Published: Oct 2018
20 citations
2113 days before retraction
The leukotriene signaling pathway: a druggable target in Alzheimer’s disease
Johanna Michael, Julia Marschallinger, Ludwig Aigner
Drug Discovery Today Open Access
Published: Sep 2018
57 citations
2127 days before retraction
Leukotriene biosynthetic enzymes as therapeutic targets
Jesper Z. Haeggström
Journal of Clinical Investigation Open Access
Published: Jul 2018
142 citations
2206 days before retraction
RETRACTED ARTICLE: Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway
Phillip F. Giannopoulos, Jian Chiu, Domenico Praticò
Molecular Neurobiology
Published: Jun 2018
19 citations
2230 days before retraction
Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase
Elisabetta Lauretti, Domenico Praticò
Journal of Alzheimer s Disease Open Access
Published: May 2018
9 citations
2257 days before retraction
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy
Antonio Di Meco, Jianguo Li, Carlos A. Barrero et al. (5 authors)
Molecular Psychiatry Open Access
Published: Apr 2018
29 citations
2268 days before retraction
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
Phillip F. Giannopoulos, Jian Chiu, Domenico Praticò
Aging Cell Open Access
Published: Apr 2018
17 citations
2297 days before retraction
The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Translational Psychiatry Open Access
Published: Dec 2017
30 citations
2404 days before retraction
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease
Elisabetta Lauretti, Domenico Praticò
Scientific Reports Open Access
Published: Dec 2017
9 citations
2418 days before retraction
RETRACTED ARTICLE: Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
Phillip F. Giannopoulos, Domenico Praticò
Molecular Neurobiology
Published: Nov 2017
15 citations
2438 days before retraction
Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò
Aging Cell Open Access
Published: Nov 2017
35 citations
2445 days before retraction
Tau-based therapies in neurodegeneration: opportunities and challenges
Chuanzhou Li, Jürgen Götz
Nature Reviews Drug Discovery
Published: Oct 2017
230 citations
2474 days before retraction
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy
Elisabetta Lauretti, Luigi Iuliano, Domenico Praticò
Annals of Clinical and Translational Neurology Open Access
Published: Jun 2017
77 citations
2581 days before retraction
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
Jianguo Li, Carlos A. Barrero, Salim Merali et al. (4 authors)
Scientific Reports Open Access
Published: Apr 2017
28 citations
2657 days before retraction
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology
Jianguo Li, Carlos A. Barrero, Salim Merali et al. (4 authors)
Human Molecular Genetics Open Access
Published: Mar 2017
11 citations
2687 days before retraction
Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
Elisabetta Lauretti, J-G Li, Antonio Di Meco et al. (4 authors)
Translational Psychiatry Open Access
Published: Jan 2017
82 citations
2722 days before retraction
Rescue of Neurons by Resolving Inflammation
Erik Hjorth, Marianne Schultzberg
Elsevier eBooks
Published: Jan 2017
1 citation
2752 days before retraction
What can lipidomics tell us about the pathogenesis of Alzheimer disease?
Yanhui Xiang, Sin Man Lam, Guanghou Shui
Biological Chemistry Open Access
Published: Jul 2015
27 citations
3272 days before retraction
Minocycline and St. John’s Wort as Therapeutic Drugs for Human Tauopathy
Kenji Hashimoto
Biological Psychiatry
Published: May 2015
2 citations
3358 days before retraction
Quick Stats
Total Citations: 45
Years Since Retraction: 1.3 year
Open Access: Yes
Last Checked: Jul 24, 2025
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