Retraction
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity
Paper Information
Record ID:
58207
Author(s):
Journal:
Publication Date:
March 16, 2009
Retraction Date:
October 29, 2024
(1.1 year years ago)
Subjects:
Institutions:
- Department for Neurosurgery, Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
- Department for Neurology, Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA3 ZZ Biotech Research Laboratory, Rochester, NY, USA
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Wiley
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (83)
83
Total Citations1
Post-Retraction(1.2%)
82
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
1
Within 1 year
0
After 2+ years
64
Days since retraction (latest)
Laboratory Diagnosis of Congenital and Acquired Protein C Deficiencies and Assays for Circulating Activated Protein C Levels
Saeed Hassani, Nader Safarian, Akbar Dorgalaleh et al. (4 authors)
Unknown Journal
Published: Jan 2025
64 days after retraction
An orthosteric/allosteric bivalent peptide agonist comprising covalently linked protease-activated receptor-derived peptides mimics in vitro and in vivo activities of activated protein C
Laura D Healy, José A. Fernández, Roberto Aiolfi et al. (5 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: Apr 2024
1 citation
1 citation
188 days before retraction
Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C
Mohammad Kasim Fatmi, Hao Wang, Lily Slotabec et al. (7 authors)
Aging
Open Access
Published: Feb 2024
7 citations
7 citations
251 days before retraction
A recombinant signalling‐selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models
Ruilong Zhao, Meilang Xue, Haiyan Lin et al. (8 authors)
Wound Repair and Regeneration
Published: Dec 2023
2 citations
2 citations
305 days before retraction
Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells
Hae‐Ryung Park, David Azzara, Ethan D. Cohen et al. (8 authors)
Journal of Hazardous Materials
Published: Nov 2023
4 citations
4 citations
363 days before retraction
Endothelial APC/PAR1 distinctly regulates cytokine-induced pro-inflammatory VCAM-1 expression
Cierra A. Birch, Helen Wedegaertner, Lennis Beatríz Orduña-Castillo et al. (6 authors)
Frontiers in Molecular Biosciences
Open Access
Published: Aug 2023
6 citations
6 citations
432 days before retraction
Diversification of PAR signaling through receptor crosstalk
Irene Lee-Rivera, Edith López, Ana María López‐Colomé
Cellular & Molecular Biology Letters
Open Access
Published: Sep 2022
17 citations
17 citations
780 days before retraction
Protease-activated receptors in health and disease
Chloe J. Peach, Laura E. Edgington‐Mitchell, Nigel W. Bunnett et al. (4 authors)
Physiological Reviews
Open Access
Published: Jul 2022
58 citations
58 citations
824 days before retraction
3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice
Yaoming Wang, Kassandra Kisler, Angeliki M. Nikolakopoulou et al. (6 authors)
Frontiers in Neuroscience
Open Access
Published: Mar 2022
18 citations
18 citations
944 days before retraction
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C
Mikko T. Huuskonen, Yaoming Wang, Angeliki M. Nikolakopoulou et al. (11 authors)
The Journal of Experimental Medicine
Open Access
Published: Nov 2021
21 citations
21 citations
1064 days before retraction
L-ARGININE AND L-GLUTAMIC ACID INCREASE THE CONTENT OF PROTEIN C IN THE EARLY STAGES OF ISOLATION FROM DONOR PLASMA
И. И. Паталах, T.F. Drobotko, А. A. Tykhomyrov
Biotechnologia Acta
Open Access
Published: Jun 2021
1 citation
1 citation
1246 days before retraction
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease
Min‐Tae Jeon, Kyu‐Sung Kim, Eun Seon Kim et al. (7 authors)
Ageing Research Reviews
Open Access
Published: Mar 2021
54 citations
54 citations
1315 days before retraction
Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation
Patrick D. Lyden, Kent E. Pryor, Jennifer Minigh et al. (7 authors)
Frontiers in Neurology
Open Access
Published: Mar 2021
13 citations
13 citations
1324 days before retraction
The Next Step in the Treatment of Stroke
Nathanael Matei, Justin Câmara, John H. Zhang
Frontiers in Neurology
Open Access
Published: Jan 2021
28 citations
28 citations
1376 days before retraction
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
Surojit Paul, Eduardo Candelario‐Jalil
Experimental Neurology
Open Access
Published: Nov 2020
573 citations
573 citations
1457 days before retraction
Low-Dose Activated Protein C Suppresses the Development of Cerebral Infarction and Neurological Deficits in Mice
Keiko Yamato, Yukako Nakajo, Hitomi Yamamoto‐Imoto et al. (8 authors)
Neurosurgery Practice
Open Access
Published: Oct 2020
1477 days before retraction
Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation
Ravi Kant, Sebok K. Halder, José A. Fernández et al. (5 authors)
Frontiers in Neuroscience
Open Access
Published: Apr 2020
26 citations
26 citations
1658 days before retraction
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function
Ying Lin, Jacob M. Wozniak, Neil Grimsey et al. (10 authors)
Proceedings of the National Academy of Sciences
Open Access
Published: Feb 2020
34 citations
34 citations
1715 days before retraction
Activated protein C assays: A review
Júlia Oto, Álvaro Fernández‐Pardo, Manuel Miralles et al. (7 authors)
Clinica Chimica Acta
Published: Nov 2019
26 citations
26 citations
1812 days before retraction
Neuroprotection and vasculoprotection using genetically targeted protease-ligands
Padmesh S. Rajput, Jessica Lamb, José A. Fernández et al. (9 authors)
Brain Research
Open Access
Published: Mar 2019
6 citations
6 citations
2056 days before retraction
Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside
Ruilong Zhao, Haiyan Lin, Lara Bereza-Malcolm et al. (6 authors)
International Journal of Molecular Sciences
Open Access
Published: Feb 2019
17 citations
17 citations
2079 days before retraction
3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
Divna Lazić, Abhay P. Sagare, Angeliki M. Nikolakopoulou et al. (6 authors)
The Journal of Experimental Medicine
Open Access
Published: Jan 2019
61 citations
61 citations
2114 days before retraction
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms
Shaun P. Jackson, Roxane Darbousset, Simone M. Schoenwaelder
Blood
Open Access
Published: Jan 2019
536 citations
536 citations
2115 days before retraction
Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents
Fangyu Du, Qifan Zhou, Xiaoxiao Fu et al. (8 authors)
RSC Advances
Open Access
Published: Jan 2019
6 citations
6 citations
2128 days before retraction
Final Results of the RHAPSODY Trial: A Multi‐Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A‐APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke
Patrick D. Lyden, Kent E. Pryor, Christopher S. Coffey et al. (31 authors)
Annals of Neurology
Open Access
Published: Nov 2018
140 citations
140 citations
2171 days before retraction
Cell biology of activated protein C
Khurrum Shahzad, Shrey Kohli, Moh’d Mohanad Al‐Dabet et al. (4 authors)
Current Opinion in Hematology
Published: Nov 2018
30 citations
30 citations
2173 days before retraction
Activated protein C, protease activated receptor 1, and neuroprotection
John H. Griffin, Berislav V. Zloković, Laurent O. Mosnier
Blood
Open Access
Published: Jun 2018
120 citations
120 citations
2339 days before retraction
RETRACTED ARTICLE: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system
Axel Montagne, Angeliki M. Nikolakopoulou, Zhen Zhao et al. (20 authors)
Nature Medicine
Open Access
Published: Feb 2018
333 citations
333 citations
2458 days before retraction
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke
Ranjeet Sinha, Yaoming Wang, Zhen Zhao et al. (12 authors)
Blood
Open Access
Published: Jan 2018
90 citations
90 citations
2477 days before retraction
Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C
Arun Paul Amar, Abhay P. Sagare, Zhen Zhao et al. (7 authors)
Neuropharmacology
Open Access
Published: Sep 2017
19 citations
19 citations
2598 days before retraction
A new concept of action of hemostatic proteases on inflammation, neurotoxicity, and tissue regeneration
Л. Р. Горбачева, Kiseleva Ev, И. Г. Савинкова et al. (4 authors)
Biochemistry (Moscow)
Published: Jul 2017
11 citations
11 citations
2677 days before retraction
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo
Laura D. Healy, Cristina Puy, José A. Fernández et al. (12 authors)
Journal of Biological Chemistry
Open Access
Published: Apr 2017
104 citations
104 citations
2755 days before retraction
Endothelial protein C receptor–dependent antichemotactic effects of canine protein C
Valerie M. Wong, Olivier Côté, Dorothee Bienzle et al. (5 authors)
American Journal of Veterinary Research
Published: Jan 2017
2828 days before retraction
Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury
William D. Whetstone, Breset A. Walker, Alpa Trivedi et al. (6 authors)
PLoS ONE
Open Access
Published: Jan 2017
13 citations
13 citations
2834 days before retraction
Coagulation factor and protease pathways in thrombosis and cardiovascular disease
Hugo Ten Cate, Tilman M. Hackeng, Pablo Garcı́a de Frutos
Thrombosis and Haemostasis
Open Access
Published: Jan 2017
72 citations
72 citations
2858 days before retraction
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research
Cesar Reis, Onat Akyol, Wing Mann Ho et al. (7 authors)
BioMed Research International
Open Access
Published: Jan 2017
40 citations
40 citations
2858 days before retraction
2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis
John H. Griffin, Laurent O. Mosnier, José A. Fernández et al. (4 authors)
Arteriosclerosis Thrombosis and Vascular Biology
Open Access
Published: Oct 2016
32 citations
32 citations
2944 days before retraction
Thrombomodulin‐dependent protein C activation is required for mitochondrial function and myelination in the central nervous system
Jan Sebastian Wolter, Lorenz Schild, Fabian Bock et al. (13 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: Sep 2016
25 citations
25 citations
2978 days before retraction
A simplified assay for the quantification of circulating activated protein C
Laura Martos, Santiago Bonanad, Luis Ramón et al. (10 authors)
Clinica Chimica Acta
Published: Jun 2016
6 citations
6 citations
3071 days before retraction
Activated protein C promotes neuroprotection: mechanisms and translation to the clinic
John H. Griffin, José A. Fernández, Patrick D. Lyden et al. (4 authors)
Thrombosis Research
Open Access
Published: May 2016
38 citations
38 citations
3103 days before retraction
Activated protein C to treat chronic wounds
Chris Jackson, Meilang Xue
Elsevier eBooks
Published: Jan 2016
3224 days before retraction
Glial Support of Blood–Brain Barrier Integrity: Molecular Targets for Novel Therapeutic Strategies in Stroke
Patrick T. Ronaldson, Thomas P. Davis
Springer series in translational stroke research
Published: Jan 2016
3224 days before retraction
Hereditary protein S deficiency leads to ischemic stroke
Z.P. Wang, Zhijun Zhao, Kang Xu et al. (7 authors)
Molecular Medicine Reports
Open Access
Published: May 2015
12 citations
12 citations
3452 days before retraction
Protective Effects of Non-Anticoagulant Activated Protein C Variant (D36A/L38D/A39V) in a Murine Model of Ischaemic Stroke
Anna P. Andreou, Maria Efthymiou, Yao Yu et al. (8 authors)
PLoS ONE
Open Access
Published: Apr 2015
14 citations
14 citations
3499 days before retraction
Deficiency of Factor <scp>VII</scp> activating protease alters the outcome of ischemic stroke in mice
Amit U. Joshi, Cyrille Orset, Britta Engelhardt et al. (7 authors)
European Journal of Neuroscience
Published: Jan 2015
30 citations
30 citations
3567 days before retraction
Purification of protein C from canine plasma
Valerie M. Wong, Dorothee Bienzle, M. Anthony Hayes et al. (5 authors)
BMC Veterinary Research
Open Access
Published: Oct 2014
1 citation
1 citation
3665 days before retraction
Effects of Activated Protein C on the Size of Modeled Ischemic Focus and Morphometric Parameters of Neurons and Neuroglia in Its Perifocal Zone
Р. М. Худоерков, И. Г. Савинкова, S. M. Strukova et al. (10 authors)
Bulletin of Experimental Biology and Medicine
Published: Aug 2014
2 citations
2 citations
3742 days before retraction
Activated protein C: A regulator of human skin epidermal keratinocyte function
Kelly J. McKelvey
World Journal of Biological Chemistry
Open Access
Published: May 2014
37 citations
37 citations
3809 days before retraction
Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers
Patrick D. Lyden, Howard Levy, Sara Weymer et al. (8 authors)
Current Pharmaceutical Design
Open Access
Published: Jan 2014
63 citations
63 citations
3949 days before retraction
Cytoprotective-selective activated protein C therapy for ischaemic stroke
Berislav V. Zloković, John H. Griffin, Laurent Mosnier
Thrombosis and Haemostasis
Open Access
Published: Jan 2014
49 citations
49 citations
3954 days before retraction
Quick Stats
Total Citations:
83
Years Since Retraction:
1.1 year
Open Access:
Yes
Last Checked:
Jul 24, 2025