Retraction
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity
Paper Information
Record ID:
58207
Author(s):
Journal:
Publication Date:
March 16, 2009
Retraction Date:
October 29, 2024
(1.1 year years ago)
Subjects:
Institutions:
- Department for Neurosurgery, Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
- Department for Neurology, Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
- Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA3 ZZ Biotech Research Laboratory, Rochester, NY, USA
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Wiley
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (83)
83
Total Citations1
Post-Retraction(1.2%)
82
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
1
Within 1 year
0
After 2+ years
64
Days since retraction (latest)
Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats
Yaoming Wang, Zhen Zhao, Nienwen Chow et al. (7 authors)
Stroke
Open Access
Published: Oct 2013
56 citations
56 citations
4022 days before retraction
Influence of the 3K3A‐activated protein C variant on the plasma clot lysis activity of t‐PA and of t‐PA on the variant's anticoagulant activity
Laurent O. Mosnier, José A. Fernández, Thomas P. Davis et al. (5 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: Sep 2013
6 citations
6 citations
4073 days before retraction
NF-κB-dependent and -independent pathways in the protective effects of activated protein C in hippocampal and cortical neurons at excitotoxicity
Lubov Gorbacheva, S. M. Strukova, Pinelis Vg et al. (6 authors)
Neurochemistry International
Published: May 2013
13 citations
13 citations
4172 days before retraction
An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR<sub>1</sub>-Akt Pathway
Huang Guo, Zhen Zhao, Qi Yang et al. (11 authors)
Journal of Neuroscience
Open Access
Published: Apr 2013
56 citations
56 citations
4227 days before retraction
Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice
Yaoming Wang, Ranjeet Sinha, Laurent O. Mosnier et al. (5 authors)
Blood Cells Molecules and Diseases
Open Access
Published: Mar 2013
9 citations
9 citations
4233 days before retraction
Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1
Yaoming Wang, Zhen Zhao, Nienwen Chow et al. (6 authors)
Brain Research
Open Access
Published: Feb 2013
29 citations
29 citations
4268 days before retraction
Immunoregulatory Proteases in Systemic Lupus Erythematosus and Lupus Nephritis
Martín Reincke
Unknown Journal
Published: Jan 2013
4319 days before retraction
Novel association of a PROC variant with ischemic stroke in a Chinese Han population
Xuan Lu, Liang Tang, Kang Xu et al. (12 authors)
Human Genetics
Published: Sep 2012
8 citations
8 citations
4429 days before retraction
Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zloković, John H. Griffin et al. (5 authors)
Current Pharmaceutical Design
Open Access
Published: Aug 2012
56 citations
56 citations
4458 days before retraction
Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke
Patrick T. Ronaldson, Thomas P. Davis
Current Pharmaceutical Design
Open Access
Published: Jul 2012
156 citations
156 citations
4479 days before retraction
An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents
Yaoming Wang, Zhenggang Zhang, Nienwen Chow et al. (7 authors)
Stroke
Open Access
Published: Jul 2012
65 citations
65 citations
4486 days before retraction
Activated protein C: reasons to believe
Ramón Montes, Javier Dı́ez, José Hermida
Journal of Thrombosis and Haemostasis
Open Access
Published: Jul 2012
3 citations
3 citations
4493 days before retraction
Protease‐activated receptor‐1 cleaved at R46 mediates cytoprotective effects
Reto A. Schuepbach, Jerzy Madon, Miriam Ender et al. (5 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: Jun 2012
82 citations
82 citations
4515 days before retraction
Protein C anticoagulant and cytoprotective pathways
John H. Griffin, Berislav V. Zloković, Laurent O. Mosnier
International Journal of Hematology
Open Access
Published: Apr 2012
128 citations
128 citations
4594 days before retraction
Thrombin in Ischemic Stroke Targeting
Bo Chen
Translational Stroke Research
Published: Jan 2012
3 citations
3 citations
4685 days before retraction
Is EPCR a multi-ligand receptor? Pros and cons
Ramón Montes, Cristina Puy, Eva Molina et al. (4 authors)
Thrombosis and Haemostasis
Published: Jan 2012
30 citations
30 citations
4685 days before retraction
expressing the anticoagulant prothrombin mutant W215A/E217A The development of inflammatory joint disease is attenuated in mice
Sherry Thornton, Leslie A. Pelc, Denisa D. Wagner et al. (14 authors)
Unknown Journal
Published: Jan 2012
4685 days before retraction
Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C
Christopher John, Meilang Xue
InTech eBooks
Open Access
Published: Dec 2011
2 citations
2 citations
4701 days before retraction
Inflammatory Diseases - A Modern Perspective
Amit Nagal
InTech eBooks
Published: Dec 2011
17 citations
17 citations
4701 days before retraction
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes
Thati Madhusudhan, Hongjie Wang, Beate K. Straub et al. (16 authors)
Blood
Open Access
Published: Nov 2011
123 citations
123 citations
4723 days before retraction
Activated protein C protects against myocardial ischemic/reperfusion injury through AMP‐activated protein kinase signaling
Jie Wang, Lili Yang, Alireza R. Rezaie et al. (4 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: May 2011
87 citations
87 citations
4929 days before retraction
Thrombin Mutant W215A/E217A Treatment Improves Neurological Outcome and Reduces Cerebral Infarct Size in a Mouse Model of Ischemic Stroke
Michelle A. Berny‐Lang, Sawan Hurst, Erik I. Tucker et al. (9 authors)
Stroke
Open Access
Published: Apr 2011
28 citations
28 citations
4938 days before retraction
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
Matthew J. Flick, Anil K. Chauhan, Malinda Frederick et al. (17 authors)
Blood
Open Access
Published: Mar 2011
38 citations
38 citations
4968 days before retraction
The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model
Enming J. Su, Melissa Geyer, Margarethe M. Wahl et al. (8 authors)
Journal of Thrombosis and Haemostasis
Open Access
Published: Mar 2011
29 citations
29 citations
4968 days before retraction
Cytoprotective protein C pathways and implications for stroke and neurological disorders
Berislav V. Zloković, John H. Griffin
Trends in Neurosciences
Open Access
Published: Feb 2011
129 citations
129 citations
4993 days before retraction
Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway
Huang Guo, Theresa M. Barrett, Zhihui Zhong et al. (7 authors)
Molecular Neurodegeneration
Open Access
Published: Feb 2011
33 citations
33 citations
5017 days before retraction
Multiple receptor-mediated functions of activated protein C
Hartmut Weiler
Hämostaseologie
Published: Jan 2011
38 citations
38 citations
5050 days before retraction
Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3–Phosphatidylinositol 3-Kinase–Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region
Zhihui Zhong, Yaoming Wang, Huang Guo et al. (10 authors)
Journal of Neuroscience
Open Access
Published: Nov 2010
58 citations
58 citations
5095 days before retraction
Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact
Corey T. Walker, Andrew Marky, Anthony L. Petraglia et al. (6 authors)
Brain Research
Open Access
Published: Jun 2010
35 citations
35 citations
5263 days before retraction
Utilidad de los biomarcadores plasmáticos en el diagnóstico, tratamiento y pronóstico de la enfermedad cerebrovascular aguda
M Iriarte, M. Teresa
TDX (Tesis Doctorals en Xarxa)
Published: Jun 2010
5264 days before retraction
Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human blood–brain barrier
Krystyna M. Cowan, Alexander S. Easton
Brain Research
Published: Mar 2010
25 citations
25 citations
5331 days before retraction
Neuron Protection as a Therapeutic Target in Acute Ischemic Stroke
Antonino Tuttolomondo, Riccardo Di Sciacca, Domenico Di Raimondo et al. (7 authors)
Current Topics in Medicinal Chemistry
Published: Oct 2009
104 citations
104 citations
5507 days before retraction
Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation
Ádám Dénes, Peter Thornton, Nancy J. Rothwell et al. (4 authors)
Brain Behavior and Immunity
Published: Sep 2009
287 citations
287 citations
5518 days before retraction
Quick Stats
Total Citations:
83
Years Since Retraction:
1.1 year
Open Access:
Yes
Last Checked:
Jul 24, 2025