Retraction

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

Paper Information

Record ID:
58804
Author(s):
Angelica Benavides-Serrato
Jihye Lee
Brent Holmes
Kenna A Landon
Tariq Bashir
Michael E Jung
Alan Lichtenstein
Joseph Gera
Journal:
PLoS One ( PLoS )
Publication Date:
April 28, 2017
Retraction Date:
September 08, 2023 (2.2 years years ago)
Subjects:
Broad Categories:
Genetics Biology Biochemistry
Institutions:
Country:
🇺🇸 United States
Article Type:
Research Article
Publisher:
PLoS
Open Access:
Yes
DOI:
10.1371/journal.pone.0176599
PubMed ID:
28453552
Retraction PubMed ID:
37682814

Retraction Details

Retraction Reasons:
Nature of Retraction:

Retraction

Retraction Notice:
10.1371/journal.pone.0291490
Additional Notes:

Alan Lichtenstein has VA finding of misconduct: see https://www.federalregister.gov/documents/2024/11/18/2024-26756/findings-of-research-misconduct-c;

Citations (79)

79
Total Citations
9
Post-Retraction
(11.4%)
69
Pre-Retraction
1
Same Day
Post-Retraction Citation Analysis
1 Within 30 days
6 Within 1 year
0 After 2+ years
472 Days since retraction (latest)
Tumor-associated macrophages enhance tumor innervation and spinal cord repair
Sissi Dolci, Loris Mannino, Alexandre Campanelli et al. (38 authors)
bioRxiv (Cold Spring Harbor Laboratory) Open Access
Published: Dec 2024
1 citation
472 days after retraction
High-density lipoprotein protects normotensive and hypertensive rats against ischemia-reperfusion injury through differential regulation of mTORC1 and mTORC2 signaling
Reham Al-Othman, Aishah Al‐Jarallah, Fawzi Babiker
Frontiers in Pharmacology Open Access
Published: Nov 2024
2 citations
433 days after retraction
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells
Tereza Kořánová, Lukáš Dvořáček, Dana Grebeňová et al. (4 authors)
Pharmacological Reports Open Access
Published: Sep 2024
369 days after retraction
mTORC2: A neglected player in aging regulation
Weitong Xu, Honghan Chen, Hengyi Xiao
Journal of Cellular Physiology
Published: Jul 2024
1 citation
306 days after retraction
Targeting autophagy drug discovery: Targets, indications and development trends
Mengjia Jiang, Wayne Wu, Zijie Xiong et al. (6 authors)
European Journal of Medicinal Chemistry
Published: Jan 2024
9 citations
137 days after retraction
Roles of Rictor alterations in gastrointestinal tumors (Review)
Ruizhen Cao, Shuilong Guo, Li Min et al. (4 authors)
Oncology Reports Open Access
Published: Jan 2024
2 citations
118 days after retraction
Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line
Maiko Sakai, Kohta Ohnishi, Masashi Masuda et al. (15 authors)
Journal of Clinical Biochemistry and Nutrition Open Access
Published: Jan 2024
115 days after retraction
Novel RICTOR amplification harbouring entities: FISH validation of RICTOR amplification in tumour tissue after next-generation sequencing
Dániel Sztankovics, Ildikó Krencz, Dorottya Moldvai et al. (15 authors)
Scientific Reports Open Access
Published: Nov 2023
6 citations
63 days after retraction
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2
Emilien Ezine, Célèste Lebbé, Nicolas Dumaz
Clinical and Translational Medicine Open Access
Published: Oct 2023
5 citations
23 days after retraction
Retraction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
Unknown Authors
PLoS ONE Open Access
Published: Sep 2023
Same day as retraction
Molecular simulations required to target novel and potent inhibitors of cancer invasion
Tian Lu, Tong Li, Mengke Wu et al. (8 authors)
Expert Opinion on Drug Discovery
Published: Sep 2023
3 citations
1 days before retraction
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function
Jianfeng Chen, Xinyi Zhang, Xianming Tan et al. (4 authors)
The Journal of Experimental Medicine
Published: Jun 2023
3 citations
71 days before retraction
mLST8 is essential for coronavirus replication and regulates its replication through the mTORC1 pathway
Yanan Fu, Zhen F. Fu, Zhelin Su et al. (11 authors)
mBio Open Access
Published: Jun 2023
8 citations
72 days before retraction
Therapeutic potential of natural compounds from herbs and nutraceuticals in spinal cord injury: Regulation of the mTOR signaling pathway
Yan Du, Xue Cai
Biomedicine & Pharmacotherapy Open Access
Published: May 2023
8 citations
114 days before retraction
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Weiwei Xu, Mirza Muhammad Fahd Qadir, Daniela Nasteska et al. (35 authors)
Cell Reports Open Access
Published: May 2023
17 citations
130 days before retraction
UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer
Sanam Sane, Rekha Srinivasan, Rashaun Potts et al. (21 authors)
Oncogene Open Access
Published: Apr 2023
6 citations
151 days before retraction
Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
Mohamed El‐Tanani, Hamdi Nsairat, Alaa A. A. Aljabali et al. (9 authors)
Life Sciences
Published: Apr 2023
19 citations
156 days before retraction
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents
Maria Antonietta Occhiuzzi, Gernando Lico, Giuseppina Ioele et al. (6 authors)
European Journal of Medicinal Chemistry
Published: Nov 2022
48 citations
284 days before retraction
Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Eunüs S. Ali, Kangkana Mitra, Shamima Akter et al. (10 authors)
Cancer Cell International Open Access
Published: Sep 2022
119 citations
358 days before retraction
Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication
Christoph C. Carter, Fred D. Mast, Jean Paul Olivier et al. (6 authors)
Frontiers in Cellular and Infection Microbiology Open Access
Published: Sep 2022
13 citations
361 days before retraction
High Glucose modulates the cancer cell fate by regulation of mTOR-HDAC-microRNA axis
M. Janaki Ramaiah, Kurappalli Rohil Kumar, Prasanna Srinivasan Ramalingam et al. (8 authors)
Research Square (Research Square) Open Access
Published: Aug 2022
388 days before retraction
A Tumor Suppressor Gene, N-myc Downstream-Regulated Gene 1 (NDRG1), in Gliomas and Glioblastomas
Yukiko Nakahara, Hiroshi Ito, Hiroki Namikawa et al. (8 authors)
Brain Sciences Open Access
Published: Apr 2022
5 citations
523 days before retraction
mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis
Deepthi Rapaka, Veera Raghavulu Bitra, Siva Reddy Challa et al. (4 authors)
Neurochemistry International
Published: Feb 2022
45 citations
562 days before retraction
The Bumpy Road towards mTOR Inhibition in Glioblastoma: Quo Vadis?
Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Biomedicines Open Access
Published: Dec 2021
7 citations
646 days before retraction
Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations
Ildikó Krencz, Dániel Sztankovics, Titanilla Dankó et al. (5 authors)
Cancer and Metastasis Reviews Open Access
Published: Dec 2021
31 citations
646 days before retraction
RICTOR Affects Melanoma Tumorigenesis and Its Resistance to Targeted Therapy
Ahlem Jebali, Maxime Battistella, Célèste Lebbé et al. (4 authors)
Biomedicines Open Access
Published: Oct 2021
15 citations
689 days before retraction
Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery
Raef Shams, Yoshihiro Ito, Hideyuki Miyatake
Pharmacology & Therapeutics Open Access
Published: Oct 2021
18 citations
695 days before retraction
Regulation of human mTOR complexes by DEPTOR
Matthias Wälchli, Karolin Berneiser, Francesca Mangia et al. (8 authors)
eLife Open Access
Published: Sep 2021
16 citations
724 days before retraction
TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer
Neeraj Agarwal, Sébastien Rinaldetti, Bassem Ben Cheikh et al. (11 authors)
Proceedings of the National Academy of Sciences Open Access
Published: Sep 2021
48 citations
725 days before retraction
Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2–Driven Regulation of Nitric Oxide and Invadopodia Formation
Divya Sahu, Jianya Huan, Huawei Wang et al. (8 authors)
American Journal Of Pathology Open Access
Published: Aug 2021
10 citations
748 days before retraction
Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype
Sana-Kay Whyte-Allman, Rupert Kaul, Reina Bendayan
Frontiers in Pharmacology Open Access
Published: Aug 2021
6 citations
765 days before retraction
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics
Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T. Saunders et al. (6 authors)
Neoplasia Open Access
Published: Jul 2021
25 citations
769 days before retraction
mTORC2: The other mTOR in autophagy regulation
Josué Ballesteros‐Álvarez, Julie K. Andersen
Aging Cell Open Access
Published: Jul 2021
139 citations
788 days before retraction
Rapamycin Pretreatment Rescues the Bone Marrow AML Cell Elimination Capacity of CAR-T Cells
Zhigang Nian, Xiaohu Zheng, Yingchao Dou et al. (9 authors)
Clinical Cancer Research Open Access
Published: Jul 2021
41 citations
793 days before retraction
RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
Timothy Catlett, Massimo M. Onesto, Alec J. McCann et al. (7 authors)
Nature Communications Open Access
Published: May 2021
26 citations
851 days before retraction
mTOR-Rictor-EGFR axis in oncogenesis and diagnosis of glioblastoma multiforme
M. Janaki Ramaiah, Rohil Kumar Kurappalli
Molecular Biology Reports
Published: May 2021
25 citations
860 days before retraction
A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma
Sakthi Lenin, Elise Ponthier, Kaitlin G. Scheer et al. (13 authors)
International Journal of Molecular Sciences Open Access
Published: Apr 2021
37 citations
870 days before retraction
Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer
Mio Harachi, Kenta Masui, Webster K. Cavenee et al. (5 authors)
Metabolites Open Access
Published: Apr 2021
24 citations
890 days before retraction
Combining mTOR Inhibitors and T Cell-Based Immunotherapies in Cancer Treatment
A. Hage, Olivier Dormond
Cancers Open Access
Published: Mar 2021
36 citations
905 days before retraction
mTOR Signaling Pathways
Jianling Xie, Christopher G. Proud
Springer eBooks
Published: Jan 2021
980 days before retraction
mTOR Signaling Pathways
Jianling Xie, Christopher G. Proud
Springer eBooks
Published: Jan 2021
980 days before retraction
Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma
Jessica Guenzle, Harue Akasaka, Katharina Joechle et al. (9 authors)
International Journal of Molecular Sciences Open Access
Published: Dec 2020
28 citations
990 days before retraction
The Role of Mammalian Target of Rapamycine Signaling Pathway in Central Nervous System Cancers: A Review
Forough Alemi Serej, Hosein Aliyari Serej, Abbas Ebrahimi‐Kalan et al. (7 authors)
The Journal of Qazvin University of Medical Sciences Open Access
Published: Dec 2020
1011 days before retraction
The 3.2-Å resolution structure of human mTORC2
Alain Scaiola, Francesca Mangia, Stefan Imseng et al. (10 authors)
Science Advances Open Access
Published: Nov 2020
83 citations
1036 days before retraction
Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication
Christoph C. Carter, Jean Paul Olivier, Alexis Kaushansky et al. (5 authors)
bioRxiv (Cold Spring Harbor Laboratory) Open Access
Published: Sep 2020
1 citation
1081 days before retraction
Research progress of mTOR inhibitors
Yifan Chen, Xiao‐Ping Zhou
European Journal of Medicinal Chemistry
Published: Sep 2020
167 citations
1090 days before retraction
Regulation of mTORC2 Signaling
Wenxiang Fu, Michael N. Hall
Genes Open Access
Published: Sep 2020
173 citations
1099 days before retraction
Developing the novel bioinformatics algorithms to systematically investigate the connections among survival time, key genes and proteins for Glioblastoma multiforme
Yujie You, Xufang Ru, Wanjing Lei et al. (8 authors)
BMC Bioinformatics Open Access
Published: Sep 2020
11 citations
1102 days before retraction
Regulation | mTOR and its Substrates
Christopher G. Proud, Jianling Xie
Elsevier eBooks
Published: Jul 2020
1163 days before retraction
The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Phillip E. MacCallum, Jacqueline Blundell
Psychopharmacology
Published: Jun 2020
10 citations
1166 days before retraction
Related Records

This article has multiple records in the database due to different notices:

Record #58803
Feb 06, 2019
Correction
Quick Stats
Total Citations: 79
Years Since Retraction: 2.2 years
Open Access: Yes
Last Checked: Jul 24, 2025
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