Retraction

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

Paper Information

Record ID:

58804

Author(s):

Angelica Benavides-Serrato
Jihye Lee
Brent Holmes
Kenna A Landon
Tariq Bashir
Michael E Jung
Alan Lichtenstein
Joseph Gera

Journal:

PLoS One ( PLoS )

Publication Date:

April 28, 2017

Retraction Date:

September 08, 2023 (2.2 years years ago)

Subjects:

Broad Categories:
Genetics Biology Biochemistry

Specific Fields:
Biochemistry Biology - Cancer Biology - Cellular Genetics

Institutions:

Country:

🇺🇸 United States

Article Type:

Research Article

Publisher:

PLoS

Open Access:

Yes

DOI:

10.1371/journal.pone.0176599

PubMed ID:

28453552

Retraction PubMed ID:

37682814

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction

Retraction Notice:

10.1371/journal.pone.0291490

Additional Notes:

Alan Lichtenstein has VA finding of misconduct: see https://www.federalregister.gov/documents/2024/11/18/2024-26756/findings-of-research-misconduct-c;

Citations (79)

79

Total Citations

9

Post-Retraction
(11.4%)

69

Pre-Retraction

1

Same Day

Post-Retraction Citation Analysis

1 Within 30 days

6 Within 1 year

0 After 2+ years

472 Days since retraction (latest)

Nuclear Functions of TOR: Impact on Transcription and the Epigenome

R. Nicholas Laribee, Ronit Weisman

Genes Open Access

Published: Jun 2020
33 citations

1185 days before retraction

The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance

Margot Riggi, Beata Kuśmider, Robbie Loewith

Journal of Cell Science Open Access

Published: May 2020
42 citations

1225 days before retraction

The 3.2Å resolution structure of human mTORC2

Alain Scaiola, Francesca Mangia, Stefan Imseng et al. (10 authors)

bioRxiv (Cold Spring Harbor Laboratory) Open Access

Published: Apr 2020
4 citations

1246 days before retraction

Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury

Ningning Chen, Pengxiang Zhou, Xizhe Liu et al. (7 authors)

The FASEB Journal Open Access

Published: Mar 2020
15 citations

1256 days before retraction

LncRNA FOXD3-AS1 Mediates AKT Pathway to Promote Growth and Invasion in Hepatocellular Carcinoma Through Regulating RICTOR

Chao Liu, Meng Zhang, Jisen Zhao et al. (8 authors)

Cancer Biotherapy and Radiopharmaceuticals

Published: Mar 2020
13 citations

1268 days before retraction

mTOR complex 2 is an integrator of cancer metabolism and epigenetics

Kenta Masui, Mio Harachi, Webster K. Cavenee et al. (5 authors)

Cancer Letters

Published: Mar 2020
33 citations

1278 days before retraction

The role of RICTOR amplification in targeted therapy and drug resistance

Deze Zhao, Man Jiang, Xiaochun Zhang et al. (4 authors)

Molecular Medicine Open Access

Published: Feb 2020
26 citations

1306 days before retraction

Wnt/beta-catenin and PI3K/Akt/mTOR Signaling Pathways in Glioblastoma: Two Main Targets for Drug Design: A Review

Seyed Hossein Shahcheraghi, Venant Tchokonte-Nana, Marzieh Lotfi et al. (6 authors)

Current Pharmaceutical Design

Published: Jan 2020
104 citations

1316 days before retraction

Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma

Angelica Benavides-Serrato, Jacquelyn T. Saunders, Brent Holmes et al. (6 authors)

International Journal of Molecular Sciences Open Access

Published: Jan 2020
25 citations

1342 days before retraction

KPT-9274, an Inhibitor of PAK4 and NAMPT, Leads to Downregulation of mTORC2 in Triple Negative Breast Cancer Cells

Emma Cordover, Janet Wei, Chadni Patel et al. (11 authors)

Chemical Research in Toxicology Open Access

Published: Dec 2019
35 citations

1352 days before retraction

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Cedric Magaway, Eugene Kim, Estela Jacinto

Cells Open Access

Published: Dec 2019
201 citations

1372 days before retraction

Sin1-mediated mTOR signaling in cell growth, metabolism and immune response

Chun Ruan, Xinxing Ouyang, Hongzhi Liu et al. (8 authors)

National Science Review Open Access

Published: Nov 2019
18 citations

1407 days before retraction

Ras functional proximity proteomics establishes mTORC2 as new direct ras effector

Joanna Kovalski, Ronald L. Shanderson, Paul A. Khavari

Oncotarget Open Access

Published: Aug 2019
10 citations

1473 days before retraction

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Kara M. Ruicci, Paul Plantinga, Nicole Pinto et al. (13 authors)

Molecular Oncology Open Access

Published: Aug 2019
29 citations

1492 days before retraction

A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity

Mario I. Vega, Yijiang Shi, Patrick Frost et al. (10 authors)

Molecular Cancer Therapeutics Open Access

Published: Aug 2019
11 citations

1492 days before retraction

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

Connor M. Blair, Nicola M. Walsh, Bruce H. Littman et al. (5 authors)

BMC Cancer Open Access

Published: Mar 2019
16 citations

1628 days before retraction

Targeting the mTORC2 signaling complex in B cell malignancies

Wei Liao, Gwen Jordaan, Angelica Benavides-Serrato et al. (6 authors)

bioRxiv (Cold Spring Harbor Laboratory) Open Access

Published: Mar 2019
1 citation

1648 days before retraction

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

Angelica Benavides-Serrato, Jihye Lee, Brent Holmes et al. (8 authors)

PLoS ONE Open Access

Published: Feb 2019
10 citations

1675 days before retraction

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna Kovalski, Aparna Bhaduri, Ashley Zehnder et al. (7 authors)

Molecular Cell Open Access

Published: Jan 2019
130 citations

1702 days before retraction

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Hannah Walters, Lynne S. Cox

International Journal of Molecular Sciences Open Access

Published: Aug 2018
74 citations

1857 days before retraction

Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex

Αναστάσιος Γκουντάκος, Sara Pilotto, Andrea Mafficini et al. (10 authors)

Carcinogenesis Open Access

Published: Jun 2018
55 citations

1900 days before retraction

Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation

Dipanjan Banerjee, Archana Sinha, Sudeshna Saikia et al. (9 authors)

Biochimie

Published: Jun 2018
24 citations

1920 days before retraction

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Hannah Walters, Lynne S. Cox

Unknown Journal Open Access

Published: Jun 2018
26 citations

1921 days before retraction

Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

Ran Xu, Jason E. Gestwicki

Current Opinion in Chemical Biology Open Access

Published: Jun 2018
236 citations

1925 days before retraction

Who does TORC2 talk to?

Jianling Xie, Xuemin Wang, Christopher G. Proud

Biochemical Journal

Published: May 2018
32 citations

1933 days before retraction

The role of RICTOR downstream of receptor tyrosine kinase in cancers

Ahlem Jebali, Nicolas Dumaz

Molecular Cancer Open Access

Published: Feb 2018
60 citations

2031 days before retraction

Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease

Simon C. Johnson

Sub-cellular biochemistry/Subcellular biochemistry

Published: Jan 2018
78 citations

2076 days before retraction

Towards specific inhibition of mTORC2

Elizabeth R. Murray, Angus J.M. Cameron

Aging Open Access

Published: Dec 2017
16 citations

2096 days before retraction

mTOR signaling in immune cells and its implications for cancer immunotherapy

Hu Zeng

Cancer Letters

Published: Sep 2017
43 citations

2193 days before retraction

Related Records

This article has multiple records in the database due to different notices:

Record #58803

Feb 06, 2019

Correction

Quick Stats

Total Citations: 79

Years Since Retraction: 2.2 years

Open Access: Yes

Last Checked: Jul 24, 2025

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