Expression of concern
Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: the TOGETHER randomized platform clinical trial
Paper Information
Record ID:
60864
Author(s):
Gilmar Reis
Eduardo Augusto dos Santos Moreira Silva
Daniela Carla Medeiros Silva
Lehana Thabane
Aline Cruz Milagres
Thiago Santiago Ferreira
Castilho Vitor Quirino dos Santos
Adhemar Dias de Figueiredo Neto
Eduardo Diniz Callegari
Leonardo Cançado Monteiro Savassi
Maria Izabel Campos Simplicio
Luciene Barra Ribeiro
Rosemary Oliveira
Ofir Harari
Holly Bailey
Jamie I Forrest
Alla Glushchenko
Sheila Sprague
Paula McKay
Craig R Rayner
Hinda Ruton
Gordon H Guyatt
Edward J Mills
Eduardo Augusto dos Santos Moreira Silva
Daniela Carla Medeiros Silva
Lehana Thabane
Aline Cruz Milagres
Thiago Santiago Ferreira
Castilho Vitor Quirino dos Santos
Adhemar Dias de Figueiredo Neto
Eduardo Diniz Callegari
Leonardo Cançado Monteiro Savassi
Maria Izabel Campos Simplicio
Luciene Barra Ribeiro
Rosemary Oliveira
Ofir Harari
Holly Bailey
Jamie I Forrest
Alla Glushchenko
Sheila Sprague
Paula McKay
Craig R Rayner
Hinda Ruton
Gordon H Guyatt
Edward J Mills
Journal:
Publication Date:
December 14, 2021
Retraction Date:
February 22, 2024
(1.7 year years ago)
Subjects:
Broad Categories:
Medicine
Medicine
Institutions:
- Research Division, Cardresearch Cardiologia Assistencial e de Pesquisa, Pontifícia Universidade Catolica de Minas Gerais, Rua Domingos Vieira 300, Sala 606 Santa Efigenia, Belo Horizonte, Minas Gerais, Brazil
- Department of Medicine, Pontifícia Universidade Catolica de Minas Gerais, Brazil
- Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada
- Public Health Care Division, Ibirite, Brazil
- Family Medicine, Mental and Public Health Department, Ouro Preto Federal University, Ouro Preto, Brazil
- Public Health Fellowship Program, Governador Valadares Public Health Authority, Brazil
- Department of Medicine, Juiz de Fora Federal University, Juiz de Fora, Brazil
- Public Health Care Division, Brumadinho, Brazil
- Cytel Inc., Vancouver, British Columbia, Canada
- Certara Inc. NJ, USA
Countries:
Article Type:
Publisher:
Elsevier
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Expression of concern Details
Retraction Reason:
Nature of Retraction:
Expression of concern
Retraction Notice:
10.1016/j.lana.2024.100703Citations (53)
53
Total Citations18
Post-Retraction(34.0%)
35
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
13
Within 1 year
0
After 2+ years
491
Days since retraction (latest)
Emerging uncertainty on the anti-aging potential of metformin
Matthew Thomas Keys, Jesper Hallas, Richard A. Miller et al. (5 authors)
Ageing Research Reviews
Open Access
Published: Jun 2025
491 days after retraction
Therapeutic options for the treatment of post-acute sequelae of COVID-19: a scoping review
Yu Bin Seo, Yu Jung Choi, Jun-Won Seo et al. (6 authors)
BMC Infectious Diseases
Open Access
Published: May 2025
455 days after retraction
Metformin as antiviral therapy protects hyperglycemic and diabetic patients
Xi Wang, Xiaojie Zheng, Honghan Ge et al. (19 authors)
mBio
Open Access
Published: May 2025
453 days after retraction
A Web of Challenges: The Therapeutic Struggle to Target NETs in Disease
Adrian I. Espiritu, Kim M. O’Sullivan
International Journal of Molecular Sciences
Open Access
Published: May 2025
449 days after retraction
Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials
Saifur Rahman Chowdhury, Nazmul Islam, Qi Zhou et al. (12 authors)
BMJ Medicine
Open Access
Published: May 2025
434 days after retraction
Klotho Deficiency in Severe COVID-19: A Unifying Hypothesis
Natalia Campos‐Obando, M. Carola Zillikens, Román F. Macaya
COVID
Open Access
Published: Nov 2024
1 citation
1 citation
274 days after retraction
Impact of blood glucose control on clinical outcomes in type 2 diabetes patients hospitalized with COVID-19 infection
Elena Chertok Shacham, Nimra Maman, Avraham Ishay
Diabetes and Vascular Disease Research
Open Access
Published: Nov 2024
253 days after retraction
Targeting AMP-activated protein kinase in sepsis
Tetsuya Yumoto, Craig M. Coopersmith
Frontiers in Endocrinology
Open Access
Published: Oct 2024
235 days after retraction
Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19
David C. Harmon, Jacqueline Levene, Christine Rutlen et al. (6 authors)
Journal of General Internal Medicine
Published: Sep 2024
2 citations
2 citations
210 days after retraction
Effect of spirulina on risk of hospitalization among patients with COVID-19: the TOGETHER randomized trial
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva et al. (22 authors)
American Journal of Clinical Nutrition
Published: Aug 2024
1 citation
1 citation
175 days after retraction
Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study
Han Na Jang, Sun Joon Moon, Jin‐Hyung Jung et al. (6 authors)
Endocrinology and Metabolism
Open Access
Published: Jun 2024
1 citation
1 citation
123 days after retraction
COVID-19 therapeutics
Daniele Focosi, Massimo Franchini, Fabrizio Maggi et al. (4 authors)
Clinical Microbiology Reviews
Published: May 2024
17 citations
17 citations
89 days after retraction
Is there room for metformin at COVID-19’s dinner table? Updated Analysis of Clinical Trials
Todd C. Lee, David R. Boulware
Clinical Infectious Diseases
Published: May 2024
3 citations
3 citations
85 days after retraction
The impact of innovative glucose-lowering drugs on the course and outcome of COVID-19 in patients with type 2 diabetes mellitus
Т. Н. Маркова, M. Stas
Diabetes Mellitus
Open Access
Published: May 2024
1 citation
1 citation
74 days after retraction
Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019
Carolyn T. Bramante, Kenneth B. Beckman, Tanvi Mehta et al. (100 authors)
Clinical Infectious Diseases
Published: May 2024
21 citations
21 citations
69 days after retraction
Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses
David Scheim, Peter Parry, David J. Rabbolini et al. (8 authors)
Viruses
Open Access
Published: Apr 2024
1 citation
1 citation
60 days after retraction
Estimating the effect of realistic improvements of metformin adherence on COVID-19 mortality using targeted machine learning
S. Qiu, Alan Hubbard, Juan Pablo Gutiérrez et al. (8 authors)
Global Epidemiology
Open Access
Published: Mar 2024
4 citations
4 citations
37 days after retraction
Is Metformin Use Associated with a More Favorable COVID-19 Course in People with Diabetes?
Giovanni Antonio Silverii, Carlo Fumagalli, Renzo Rozzini et al. (6 authors)
Journal of Clinical Medicine
Open Access
Published: Mar 2024
4 citations
4 citations
31 days after retraction
A Dual Pharmacological Strategy against COVID-19: The Therapeutic Potential of Metformin and Atorvastatin
Luis Adrián De Jesús‐González, Rosa M. del Ángel, Selvin Noé Palacios-Rápalo et al. (15 authors)
Microorganisms
Open Access
Published: Feb 2024
6 citations
6 citations
9 days before retraction
Metformin Alters mRNA Expression of FOXP3, RORC, and TBX21 and Modulates Gut Microbiota in COVID-19 Patients with Type 2 Diabetes
Pavlo Petakh, Iryna Kamyshna, Valentyn Oksenych et al. (4 authors)
Viruses
Open Access
Published: Feb 2024
10 citations
10 citations
11 days before retraction
Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study
Han Na Jang, Sun Joon Moon, Jin‐Hyung Jung et al. (6 authors)
Endocrinology and Metabolism
Open Access
Published: Jan 2024
24 days before retraction
Outpatient randomized controlled trials to reduce COVID‐19 hospitalization: Systematic review and meta‐analysis
David J. Sullivan, Daniele Focosi, Daniel F. Hanley et al. (8 authors)
Journal of Medical Virology
Open Access
Published: Dec 2023
22 citations
22 citations
83 days before retraction
Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses
Eric A. Meyerowitz, Yijia Li
Clinical Infectious Diseases
Open Access
Published: Nov 2023
13 citations
13 citations
105 days before retraction
Antidiabetic Drug Efficacy in Reduction of Mortality during the COVID-19 Pandemic
Daniel Gonikman, Dmitrijs Kustovs
Medicina
Open Access
Published: Oct 2023
7 citations
7 citations
134 days before retraction
Unveiling the potential pleiotropic effects of metformin in treating COVID-19: a comprehensive review
Pavlo Petakh, Iryna Kamyshna, Oleksandr Kamyshnyi
Frontiers in Molecular Biosciences
Open Access
Published: Oct 2023
7 citations
7 citations
135 days before retraction
A wonder drug? New discoveries potentiate new therapeutic potentials of metformin
Alyssa Matz, Beiyan Zhou
Obesity Medicine
Published: Oct 2023
144 days before retraction
The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases
Mónika Szilveszter, Sándor Pál, Zsuzsánna Simon-Szabó et al. (10 authors)
International Journal of Molecular Sciences
Open Access
Published: Aug 2023
4 citations
4 citations
192 days before retraction
Metformin for Treatment of Acute COVID-19: Systematic Review of Clinical Trial Data Against SARS-CoV-2
Spencer M Erickson, Sarah L. Fenno, Nir Barzilai et al. (8 authors)
Diabetes Care
Open Access
Published: Jun 2023
18 citations
18 citations
247 days before retraction
Clinically Evaluated COVID-19 Drugs with Therapeutic Potential for Biological Warfare Agents
Ido-David Dechtman, Ran Ankory, Keren Sokolinsky et al. (6 authors)
Microorganisms
Open Access
Published: Jun 2023
253 days before retraction
Effectiveness of famotidine on the risk of poor prognosis in patients with COVID-19: A nationwide cohort study in Korea
Rosie Kwon, Hyung‐Jun Kim, Seung Won Lee et al. (8 authors)
Heliyon
Open Access
Published: Jun 2023
3 citations
3 citations
266 days before retraction
Preparing for the next viral threat with broad-spectrum antivirals
Marwah Karim, Chieh‐Wen Lo, Shirit Einav
Journal of Clinical Investigation
Open Access
Published: May 2023
40 citations
40 citations
267 days before retraction
Metformin for treatment of Covid-19: evidence from randomized trials
Unknown Authors
International Journal of Pharmacy and Infections Therapy
Open Access
Published: May 2023
271 days before retraction
When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples
David Scheim, Colleen Aldous, Barbara Osimani et al. (5 authors)
Journal of Clinical Medicine
Open Access
Published: May 2023
4 citations
4 citations
275 days before retraction
Paxlovid for Treating COVID-19 Patients: A Case-Control Study From Two Hospitals in the Eastern Province of Saudi Arabia
Ali Alsaeed, Abdullah Alkhalaf, Ali A Alomran et al. (6 authors)
Cureus
Open Access
Published: May 2023
3 citations
3 citations
279 days before retraction
Metformin: update on mechanisms of action and repurposing potential
Marc Foretz, Bruno Guigas, Benoı̂t Viollet
Nature Reviews Endocrinology
Open Access
Published: May 2023
385 citations
385 citations
296 days before retraction
Metformin in COVID-19: Is There a Role Beyond Glycemic Control?
Lakshmi Nagendra, Saptarshi Bhattacharya, Sanjay Kalra et al. (4 authors)
International Journal of Endocrinology and Metabolism
Open Access
Published: Apr 2023
1 citation
1 citation
308 days before retraction
Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva et al. (100 authors)
Annals of Internal Medicine
Open Access
Published: Apr 2023
30 citations
30 citations
311 days before retraction
Analogies between COVID-19 and Preeclampsia: Focus on Therapies
Valentina Giardini, Carlo Gambacorti‐Passerini, Marco Casati et al. (5 authors)
International Journal of Translational Medicine
Open Access
Published: Apr 2023
5 citations
5 citations
322 days before retraction
Antidiabetic Treatment before Hospitalization and Admission Parameters in Patients with Type 2 Diabetes, Obesity, and SARS-CoV-2 Viral Infection
Patricia-Andrada Reștea, Mariana Mureşan, Adrian Voicu et al. (9 authors)
Journal of Personalized Medicine
Open Access
Published: Feb 2023
2 citations
2 citations
364 days before retraction
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
Bibo Zhu, Xiaoqin Wei, Harish Narasimhan et al. (20 authors)
Science Immunology
Open Access
Published: Feb 2023
28 citations
28 citations
364 days before retraction
Platform trials for anaesthesia and perioperative medicine: a narrative review
Paul S. Myles, Joyce Yeung, W. Scott Beattie et al. (6 authors)
British Journal of Anaesthesia
Open Access
Published: Nov 2022
9 citations
9 citations
451 days before retraction
Metformin use and mortality and length of stay among hospitalized patients with type 2 diabetes and COVID-19: A multiracial, multiethnic, urban observational study
Emily Miao, Kaleena Zhang, Jianyou Liu et al. (6 authors)
Frontiers in Endocrinology
Open Access
Published: Nov 2022
3 citations
3 citations
470 days before retraction
Targeting T cell (oxidative) metabolism to improve immunity to viral infection in the context of obesity
Elizabeth Greene, Nancie J. MacIver
Frontiers in Immunology
Open Access
Published: Oct 2022
6 citations
6 citations
504 days before retraction
COVID‐19 immunopathology: From acute diseases to chronic sequelae
Mohd Arish, Wei Qian, Harish Narasimhan et al. (4 authors)
Journal of Medical Virology
Open Access
Published: Sep 2022
47 citations
47 citations
537 days before retraction
Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19
Carolyn T. Bramante, Jared D. Huling, Christopher J. Tignanelli et al. (37 authors)
New England Journal of Medicine
Open Access
Published: Aug 2022
214 citations
214 citations
554 days before retraction
Metformin therapy in COVID-19: inhibition of NETosis
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan
Journal of Thrombosis and Thrombolysis
Open Access
Published: Jun 2022
4 citations
4 citations
630 days before retraction
Surgisphere II: Repeated refusals to disclose the death and hospitalization rates for the TOGETHER trial, ivermectin vs. placebo
David Scheim, Jerome Dancis, Colleen Aldous
Unknown Journal
Open Access
Published: May 2022
634 days before retraction
Antidepressants for COVID-19: A systematic review
Wei Zheng, Heli Sun, Hong Cai et al. (6 authors)
Journal of Affective Disorders
Open Access
Published: Mar 2022
25 citations
25 citations
701 days before retraction
COVID-19 breakthrough infections, hospitalizations and mortality in fully vaccinated patients with hematologic malignancies: A clarion call for maintaining mitigation and ramping-up research
Lindsey Wang, David C. Kaelber, Rong Xu et al. (4 authors)
Blood Reviews
Open Access
Published: Jan 2022
66 citations
66 citations
752 days before retraction
Editorial: Obesity, metabolic phenotypes and COVID-19
Despina Sanoudou, Michael A. Hill, Matthew J. Belanger et al. (5 authors)
Metabolism
Open Access
Published: Jan 2022
27 citations
27 citations
773 days before retraction
Quick Stats
Total Citations:
53
Years Since Retraction:
1.7 year
Open Access:
Yes
Last Checked:
Jul 24, 2025