Retraction
Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway
Paper Information
Record ID:
64719
Author(s):
Publication Date:
February 06, 2015
Retraction Date:
March 21, 2025
(<1 year years ago)
Subjects:
Institutions:
Country:
🇨🇳 ChinaArticle Type:
Publisher:
PLoS
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
Nature of Retraction:
Retraction
Retraction Notice:
10.1371/journal.pone.0321151Citations (92)
92
Total Citations1
Post-Retraction(1.1%)
90
Pre-Retraction1
Same DayPost-Retraction Citation Analysis
0
Within 30 days
1
Within 1 year
0
After 2+ years
52
Days since retraction (latest)
Monitoring the Early Response of Fulvestrant Plus Tanshinone IIA Combination Therapy to Estrogen Receptor-Positive Breast Cancer by Longitudinal <sup>18</sup>F-FES PET/CT
Simin He, Mingwei Wang, Yongping Zhang et al. (5 authors)
Contrast Media & Molecular Imaging
Open Access
Published: Jun 2019
8 citations
8 citations
2111 days before retraction
Silencing PDK1 limits hypoxia‑induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway
Ruo‐Min Di, Zhongzhou Yang, Peng Xu et al. (4 authors)
Experimental and Therapeutic Medicine
Open Access
Published: May 2019
19 citations
19 citations
2123 days before retraction
Vanillic Acid Suppresses HIF-1α Expression via Inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK Pathways in Human Colon Cancer HCT116 Cells
Gong Jing-li, Shengxue Zhou, Shihai Yang
International Journal of Molecular Sciences
Open Access
Published: Jan 2019
102 citations
102 citations
2250 days before retraction
Pro‐Angiogenic and Anti‐Angiogenic Effects of Small Molecules from Natural Products
Jingyi Ma, Xuelin Zhou
Unknown Journal
Published: Dec 2018
1 citation
1 citation
2275 days before retraction
Tanshinone II A improves distribution and anti-tumor efficacy of pegylated liposomal doxorubicin via normalizing the structure and function of tumor vasculature in hepa1-6 hepatoma mice model
Ying Zhang, Tie Minghui, Feng Bi et al. (4 authors)
Deleted Journal
Open Access
Published: Dec 2018
7 citations
7 citations
2302 days before retraction
Vandetanib (ZD6474) induces antiangiogenesis through mTOR&ndash;HIF-1 alpha&ndash;VEGF signaling axis in breast cancer cells
Ling Li, Jing-kui Yu, Shuhong Jiao et al. (6 authors)
OncoTargets and Therapy
Open Access
Published: Nov 2018
23 citations
23 citations
2332 days before retraction
HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells
Jia-Hau Yen, Sheng‐Teng Huang, Hung-Sen Huang et al. (7 authors)
Cell Death and Disease
Open Access
Published: Sep 2018
49 citations
49 citations
2368 days before retraction
Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways
Haitao Wang, Xiaoying Su, Jiankang Fang et al. (10 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2018
22 citations
22 citations
2382 days before retraction
Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer
Yongjun Zhang, Shuguang Guo, Jian‐Hong Fang et al. (6 authors)
Experimental and Therapeutic Medicine
Open Access
Published: Aug 2018
39 citations
39 citations
2423 days before retraction
Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine
Cheng Zhang, Ning Wang, Hor‐Yue Tan et al. (6 authors)
Integrative Cancer Therapies
Open Access
Published: May 2018
29 citations
29 citations
2489 days before retraction
MiR-429 Regulated by Endothelial Monocyte Activating Polypeptide-II (EMAP-II) Influences Blood-Tumor Barrier Permeability by Inhibiting the Expressions of ZO-1, Occludin and Claudin-5
Liangyu Chen, Yixue Xue, Jian Zheng et al. (12 authors)
Frontiers in Molecular Neuroscience
Open Access
Published: Feb 2018
23 citations
23 citations
2600 days before retraction
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Jianheng Peng, Xiaolin Wang, Ran Liang et al. (6 authors)
Journal of Breast Cancer
Open Access
Published: Jan 2018
37 citations
37 citations
2636 days before retraction
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility
Bin Huang, Zhong-Yan Zhou, Li Shang et al. (7 authors)
Pharmacological Research
Published: Oct 2017
28 citations
28 citations
2717 days before retraction
Tanshinone IIA Inhibits VEGF Secretion and HIF-1α Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia
Rami M. Alzhrani, Qasim Alhadidi, Rinda Devi Bachu et al. (6 authors)
Current Eye Research
Open Access
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19 citations
19 citations
2737 days before retraction
Tanshinone IIA attenuates nerve transection injury associated with nerve regeneration promotion in rats
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Neuroscience Letters
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Published: Aug 2017
12 citations
12 citations
2759 days before retraction
Participación de HIF-1 en la regulación de la autofagia inducida farmacológicamente en células tumorales de mama y de colon
Rebeca Salgado García
Unknown Journal
Open Access
Published: Aug 2017
2761 days before retraction
Neocortical developmental analysis of vasculature and their growth factors offer new insight into fragile X syndrome abnormalities
Amogh P. Belagodu, Stephen A. Fleming, Roberto Galvez
Developmental Neurobiology
Published: Jul 2017
6 citations
6 citations
2803 days before retraction
Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice
Yao Liu, Xu Wang, Ying Jia et al. (4 authors)
International Journal of Molecular Medicine
Open Access
Published: Jun 2017
13 citations
13 citations
2828 days before retraction
Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer
Hua Sui, Jihui Zhao, Lihong Zhou et al. (13 authors)
Cancer Letters
Published: Jun 2017
150 citations
150 citations
2844 days before retraction
Site-selective Csp 3 -H aryloxylation of natural product Tanshinone IIA and its analogues
Bing Liang, Shujuan Yu, Jie Li et al. (7 authors)
Tetrahedron Letters
Published: Mar 2017
12 citations
12 citations
2915 days before retraction
Paper citing Tanshinone IIA inhibits HIF-1α and VEGF expression...
Unknown Authors
Unknown Journal
Published: Mar 2017
2915 days before retraction
Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway
Ching-Yuan Wu, Yao‐Hsu Yang, Yin-Yin Lin et al. (14 authors)
Oncotarget
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Published: Feb 2017
53 citations
53 citations
2970 days before retraction
Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction
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Scientific Reports
Open Access
Published: Jan 2017
40 citations
40 citations
2982 days before retraction
Anticancer Activity of Salvia miltiorrhiza and Its Secondary Metabolites
Ching‐Fen Wu, Thomas Efferth
Springer eBooks
Published: Jan 2017
2 citations
2 citations
3001 days before retraction
MiR-129-5p Sensitizes the Response of Her-2 Positive Breast Cancer to Trastuzumab by Reducing Rps6
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Cellular Physiology and Biochemistry
Open Access
Published: Jan 2017
37 citations
37 citations
3001 days before retraction
Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way
Jun Xie, Jiahui Liu, Heng Liu et al. (11 authors)
BMC Cancer
Open Access
Published: Nov 2016
54 citations
54 citations
3045 days before retraction
Catalyst-Free sp<sup>3</sup> C–H Acyloxylation: Regioselective Synthesis of 1-Acyloxy Derivatives of the Natural Product Tanshinone IIA
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Journal of Natural Products
Published: Sep 2016
23 citations
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3097 days before retraction
Blocking elevated VEGF‐A attenuates non‐vasculature Fragile X syndrome abnormalities
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Developmental Neurobiology
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13 citations
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3210 days before retraction
Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective
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4 citations
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3276 days before retraction
Paper citing Tanshinone IIA inhibits HIF-1α and VEGF expression...
Unknown Authors
Unknown Journal
Published: Mar 2016
3280 days before retraction
eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation
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Cancer Letters
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25 citations
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Proteome-Wide Effect of 17-β-Estradiol and Lipoxin A4 in an Endometriotic Epithelial Cell Line
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3 citations
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3362 days before retraction
The interplay between autophagy and apoptosis induced by tanshinone IIA in prostate cancer cells
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32 citations
32 citations
3378 days before retraction
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20 citations
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3401 days before retraction
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76 citations
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3409 days before retraction
Tanshinone IIA inhibits acute promyelocytic leukemia cell proliferation and induces their apoptosis in vivo
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28 citations
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3430 days before retraction
<i>In vitro</i> anti-tumor activity of the tanshinone IIA against SKOV3 cells
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Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines
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14 citations
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Tanshinone IIA enhances the effects of TRAIL by downregulating survivin in human ovarian carcinoma cells
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23 citations
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3543 days before retraction
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12 citations
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3549 days before retraction
Renal Toxicities of Targeted Therapies
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Related Records
This article has multiple records in the database due to different notices:
Record #64720
May 12, 2025Quick Stats
Total Citations:
92
Years Since Retraction:
<1 year
Open Access:
Yes
Last Checked:
Jul 23, 2025