Retraction
The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy
Paper Information
Record ID:
64805
Publication Date:
March 19, 2014
Retraction Date:
March 12, 2024
(1.7 year years ago)
Subjects:
Institutions:
- Department of Cardiovascular Medicine, Central Hospital of Xuzhou, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China
- Department of Ultrasonography, Central Hospital of Xuzhou, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China
Country:
🇨🇳 ChinaArticle Type:
Publisher:
PLoS
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Retraction Details
Retraction Reasons:
Nature of Retraction:
Retraction
Retraction Notice:
10.1371/journal.pone.0300689Citations (44)
44
Total Citations3
Post-Retraction(6.8%)
40
Pre-Retraction1
Same DayPost-Retraction Citation Analysis
0
Within 30 days
2
Within 1 year
0
After 2+ years
479
Days since retraction (latest)
Harnessing the therapeutic value of Tanshinone IIA: a breakthrough therapy in cardiovascular diseases
Lei Du, Chengyan Guan, Hao Zhang et al. (5 authors)
Frontiers in Pharmacology
Open Access
Published: Jul 2025
479 days after retraction
Pharmacological and toxicological effects of Jiangfangbaoxin and determination of its components in the blood of spontaneously hypertensive rats
Zhiqi Shi, Qing Wang, Fan Jia et al. (5 authors)
Scientific Reports
Open Access
Published: Feb 2025
335 days after retraction
Unveiling the Mechanism of Protective Effects of Tanshinone as a New Fighter Against Cardiovascular Diseases: A Systematic Review
Mohammad Mahdi Dabbaghi, Hesan Soleimani Roudi, Rozhan Safaei et al. (6 authors)
Cardiovascular Toxicology
Published: Sep 2024
3 citations
3 citations
194 days after retraction
Retraction: The Complex Regulation of Tanshinone IIA in Rats with Hypertension-Induced Left Ventricular Hypertrophy
Unknown Authors
PLoS ONE
Open Access
Published: Mar 2024
Same day as retraction
The recent advance and prospect of natural source compounds for the treatment of heart failure
Xingjuan Chen, Siyuan Liu, Siming Li et al. (11 authors)
Heliyon
Open Access
Published: Feb 2024
7 citations
7 citations
16 days before retraction
The mechanisms of tanshinone in the treatment of tumors
Pengyu Zhang, Wendi Liu, Yuan Wang
Frontiers in Pharmacology
Open Access
Published: Oct 2023
11 citations
11 citations
138 days before retraction
Chemical Characterization of Phytoconstituents for Lifestyle Diseases
Yvan Anderson T. Ngandjui, Joseph Tchamgoue, Donald Ulrich Kenou Kagho et al. (6 authors)
Unknown Journal
Published: Jan 2023
436 days before retraction
A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment
Zhangyang Bi, Yayun Wang, Caiqing Zhang
Biomedicine & Pharmacotherapy
Open Access
Published: Mar 2021
40 citations
40 citations
1106 days before retraction
Protective Effects of Shenfuyixin Granule on H2O2-Induced Apoptosis in Neonatal Rat Cardiomyocytes
Xinlu Wang, Xuanxuan Hao, Youping Wang et al. (8 authors)
Evidence-based Complementary and Alternative Medicine
Open Access
Published: Jan 2021
1138 days before retraction
Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases
Zhibei Li, Jing Zou, Dan Cao et al. (4 authors)
Biomedicine & Pharmacotherapy
Open Access
Published: Aug 2020
49 citations
49 citations
1302 days before retraction
Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents
Fatima Saqib, Muhammad Arif Aslam, Khizra Mujahid et al. (7 authors)
Molecules
Open Access
Published: Jul 2020
7 citations
7 citations
1321 days before retraction
<p>Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis</p>
Hong Xu, Haiqing Li, Pengxiong Zhu et al. (6 authors)
Drug Design Development and Therapy
Open Access
Published: Jul 2020
13 citations
13 citations
1350 days before retraction
A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis
Miao-Juan Shi, Xiuli Yan, Ben-Sheng Dong et al. (6 authors)
Journal of Ethnopharmacology
Published: Feb 2020
49 citations
49 citations
1479 days before retraction
Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents
Matteo Micucci, Cristiano Bolchi, Roberta Budriesi et al. (9 authors)
Phytochemistry
Open Access
Published: Dec 2019
14 citations
14 citations
1560 days before retraction
Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM
Ying Wang, Ruonan Zhang, Hailin Shen et al. (5 authors)
Bioscience Reports
Open Access
Published: Dec 2019
6 citations
6 citations
1563 days before retraction
<i>Bacopa monniera</i> extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway
T. Mohan Manu, T. Anand, G. R. Sharath Babu et al. (5 authors)
Archives of Physiology and Biochemistry
Published: Nov 2019
4 citations
4 citations
1572 days before retraction
Phytochemicals as potential IKK-β inhibitor for the treatment of cardiovascular diseases in plant preservation: terpenoids, alkaloids, and quinones
Fang Hua, Lingli Shi, Peng Zhou
Inflammopharmacology
Published: Sep 2019
12 citations
12 citations
1650 days before retraction
Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2
Mailin Gan, Ting Zheng, Linyuan Shen et al. (11 authors)
Biomedicine & Pharmacotherapy
Open Access
Published: Feb 2019
37 citations
37 citations
1846 days before retraction
Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats
Zhiyong Wang, Xiaomei Yang, Weiguang Zhang et al. (5 authors)
PLoS ONE
Open Access
Published: Aug 2018
10 citations
10 citations
2028 days before retraction
Tanshinone IIA effects on ovarian cancer cell line
Nan Li, Liang Yang, Baolian Zhang et al. (4 authors)
Journal of Pharmacy and Pharmacology
Published: Jun 2018
25 citations
25 citations
2087 days before retraction
Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF‐κB signaling pathways
Fabo Feng, Hai‐Yan Qiu
The Kaohsiung Journal of Medical Sciences
Open Access
Published: Apr 2018
23 citations
23 citations
2146 days before retraction
Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
Zhuo-ming Li, Suowen Xu, Peiqing Liu
Acta Pharmacologica Sinica
Open Access
Published: Apr 2018
431 citations
431 citations
2147 days before retraction
<i>Retracted:</i> Tanshinone <scp>IIA</scp> prevents left ventricular remodelling via the <scp>TLR</scp>4/MyD88/<scp>NF</scp>‐κB signalling pathway in rats with myocardial infarction
Dongmei Wu, Yong‐Jian Wang, Xin‐Rui Han et al. (8 authors)
Journal of Cellular and Molecular Medicine
Open Access
Published: Mar 2018
50 citations
50 citations
2194 days before retraction
Blockage of AKAP12 accelerates angiotensin II (Ang II)-induced cardiac injury in mice by regulating the transforming growth factor β1 (TGF-β1) pathway
Yong Li, Qiuhua Yu, Ying Chu et al. (7 authors)
Biochemical and Biophysical Research Communications
Published: Mar 2018
14 citations
14 citations
2198 days before retraction
Tanshinone IIA ameliorates apoptosis of myocardiocytes by up-regulation of miR-133 and suppression of Caspase-9
Tao Song, Yuan Yao, Teng Wang et al. (5 authors)
European Journal of Pharmacology
Published: Sep 2017
45 citations
45 citations
2384 days before retraction
Tanshinone IIA attenuates nerve transection injury associated with nerve regeneration promotion in rats
Li Mo, Jingyi Wang, Lixiang Ding et al. (6 authors)
Neuroscience Letters
Open Access
Published: Aug 2017
12 citations
12 citations
2385 days before retraction
Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy
Ya‐Fang Chen, N. Lee, Pei‐Ying Pai et al. (11 authors)
Journal of Receptors and Signal Transduction
Published: Aug 2017
14 citations
14 citations
2400 days before retraction
Gardenia jasminoides has therapeutic effects on L-NNA-induced hypertension in vivo
Shaocheng Chen, Peng Sun, Xin Zhao et al. (7 authors)
Molecular Medicine Reports
Published: May 2017
26 citations
26 citations
2506 days before retraction
Tanshinone IIA protects against pulmonary arterial hypertension in broilers
Guoliang Hu, Yalu Song, Shanlin Ke et al. (11 authors)
Poultry Science
Open Access
Published: Oct 2016
8 citations
8 citations
2715 days before retraction
RETRACTED: The effects of tanshinone IIA on hypoxia/reoxygenation-induced myocardial microvascular endothelial cell apoptosis in rats via the JAK2/STAT3 signaling pathway
Zhen-Tian Cui, Jianping Liu, Wanlin Wei
Biomedicine & Pharmacotherapy
Published: Aug 2016
27 citations
27 citations
2761 days before retraction
Tanshinone IIA ameliorates apoptosis of cardiomyocytes induced by endoplasmic reticulum stress
Jun Feng, Shusheng Li, Chen Hua-wen
Experimental Biology and Medicine
Open Access
Published: Jul 2016
17 citations
17 citations
2784 days before retraction
Therapeutic Effects of Tanshinone IIA towards Early Renal Damage in Patients with Type 2 Diabetes
FULONG HAN, Sheng Li, Qi Jian et al. (4 authors)
West Indian Medical Journal
Open Access
Published: Apr 2016
1 citation
1 citation
2897 days before retraction
Molecular Mechanisms of Cardioprotective Actions of Tanshinones
Hyou-Ju Jin, Chun Guang Li
Journal of Chemistry
Open Access
Published: Jan 2016
4 citations
4 citations
2993 days before retraction
Tanshinone IIA promotes the proliferation of WB-F344 hepatic oval cells via Wnt/β-catenin signaling
Xingyu Ze, Jidong Jia, Xinmin Li et al. (7 authors)
Molecular Medicine Reports
Open Access
Published: Dec 2015
16 citations
16 citations
3007 days before retraction
Tanshinone <scp>IIA</scp> treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A
Shuai Ma, W Liu, P. Liu et al. (6 authors)
Journal of Periodontal Research
Published: Nov 2015
7 citations
7 citations
3048 days before retraction
Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells
Yu Jin Jeon, Joong‐Sun Kim, Geun Hye Hwang et al. (11 authors)
European Journal of Pharmacology
Published: Jul 2015
43 citations
43 citations
3157 days before retraction
Herbal drugs against cardiovascular disease: traditional medicine and modern development
Lingjun Li, Xiuwen Zhou, Na Li et al. (6 authors)
Drug Discovery Today
Published: May 2015
62 citations
62 citations
3233 days before retraction
The role of TIMPs in regulation of extracellular matrix proteolysis
Valerie Arpino, Michael S. Brock, Sean E. Gill
Matrix Biology
Open Access
Published: Apr 2015
644 citations
644 citations
3256 days before retraction
Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction
Huilin Hu, Changlin Zhai, Gang Qian et al. (12 authors)
Pharmaceutical Biology
Open Access
Published: Apr 2015
73 citations
73 citations
3256 days before retraction
Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells
Li‐Ling Lin, Chieh-Ren Hsia, Chia‐Lang Hsu et al. (5 authors)
BMC Genomics
Open Access
Published: Feb 2015
49 citations
49 citations
3324 days before retraction
microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling
Fan Yang, Ping Li, Haiyu Li et al. (6 authors)
Journal of Cardiovascular Pharmacology
Published: Jan 2015
31 citations
31 citations
3329 days before retraction
Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="italic">β</mml:mi></mml:mrow></mml:math>
Mingjie Zhou, Huanhuan Ren, Jichun Han et al. (6 authors)
Oxidative Medicine and Cellular Longevity
Open Access
Published: Jan 2015
113 citations
113 citations
3358 days before retraction
The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats
Nam Nhut Phan, Chih‐Yang Wang, Yen-Chang Lin
Toxicology
Published: Jul 2014
28 citations
28 citations
3513 days before retraction
Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain
Yuqing Ma, Yi‐Rong Chen, Yufang Leng et al. (4 authors)
Evidence-based Complementary and Alternative Medicine
Open Access
Published: Jan 2014
33 citations
33 citations
3723 days before retraction
Quick Stats
Total Citations:
44
Years Since Retraction:
1.7 year
Open Access:
Yes
Last Checked:
Jul 24, 2025