Retraction
Upregulation of mTORC2 Activation by the Selective Agonist of EPAC, 8-CPT-2Me-cAMP, in Prostate Cancer Cells: Assembly of a Multiprotein Signaling Complex
Paper Information
Record ID:
66191
Author(s):
Journal:
Publication Date:
December 15, 2011
Retraction Date:
July 15, 2025
(<1 year years ago)
Subjects:
Country:
🇺🇸 United StatesArticle Type:
Publisher:
Wiley
Open Access:
Yes
DOI:
PubMed ID:
Retraction PubMed ID:
Retraction Details
Citations (41)
41
Total Citations0
Post-Retraction41
Pre-Retraction0
Same DayRetraction: Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells
Unknown Authors
PLoS ONE
Open Access
Published: Jun 2025
1 citation
1 citation
40 days before retraction
Retraction: Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with raptor
Unknown Authors
PLoS ONE
Open Access
Published: Jun 2025
2 citations
2 citations
40 days before retraction
The mTORC2 signaling network: targets and cross-talks
Aparna Ragupathi, Christian Kim, Estela Jacinto
Biochemical Journal
Open Access
Published: Jan 2024
35 citations
35 citations
537 days before retraction
Revisiting the roles of cAMP signalling in the progression of prostate cancer
Emma C. Parsons, Ralf Hoffmann, George S. Baillie
Biochemical Journal
Open Access
Published: Oct 2023
3 citations
3 citations
641 days before retraction
Cell surface GRP78: a potential mechanism of therapeutic resistant tumors
Rajalakshmi Amaresan, Udhayakumar Gopal
Cancer Cell International
Open Access
Published: May 2023
26 citations
26 citations
784 days before retraction
The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane
Mei-Ling Li, Aparna Ragupathi, Nikhil Patel et al. (8 authors)
Journal of Biological Chemistry
Open Access
Published: Aug 2022
7 citations
7 citations
1053 days before retraction
The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
Zhengyin Gao, Weng I Lei, Leo Tsz On Lee
Molecules
Open Access
Published: Jan 2022
13 citations
13 citations
1287 days before retraction
Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention
Nazanin Momeni Roudsari, Naser‐Aldin Lashgari, Saeideh Momtaz et al. (12 authors)
Pharmaceutics
Open Access
Published: Aug 2021
54 citations
54 citations
1442 days before retraction
Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis
Siddharth Sunilkumar, Scot R. Kimball, Michael D. Dennis
Cellular Signalling
Open Access
Published: Apr 2021
6 citations
6 citations
1549 days before retraction
Regulation and metabolic functions of mTORC1 and mTORC2
Angelia Szwed, Eugene Kim, Estela Jacinto
Physiological Reviews
Open Access
Published: Feb 2021
517 citations
517 citations
1608 days before retraction
Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold
Prasanna K.R. Allu, Esther Paulo, Ambre M. Bertholet et al. (11 authors)
Journal of Biological Chemistry
Open Access
Published: Jan 2021
14 citations
14 citations
1656 days before retraction
The Role of Epac in Cancer Progression
Nadine Wehbe, Hasan Slika, Joelle Mesmar et al. (10 authors)
International Journal of Molecular Sciences
Open Access
Published: Sep 2020
31 citations
31 citations
1774 days before retraction
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
Sonu Kashyap, Kyaw Zaw Hein, Claudia C.S. Chini et al. (11 authors)
JCI Insight
Open Access
Published: Jan 2020
23 citations
23 citations
1995 days before retraction
Phosphorylated ERM Mediates Lipopolysaccharide Induced Pulmonary Microvascular Endothelial Cells Permeability Through Negatively Regulating Rac1 Activity
Liming Fei, Gengyun Sun, Zhongming Zhu et al. (4 authors)
Archivos de Bronconeumología
Published: Jun 2019
1 citation
1 citation
2236 days before retraction
Simultaneous activation of PKA and Epac is cardioprotective in neonatal and adult hearts
Martin Lewis
Unknown Journal
Published: Jan 2019
2387 days before retraction
Phosphorylated ERM Mediates Lipopolysaccharide Induced Pulmonary Microvascular Endothelial Cells Permeability Through Negatively Regulating Rac1 Activity
Liming Fei, Gengyun Sun, Zhongming Zhu et al. (4 authors)
Archivos de Bronconeumología
Published: Nov 2018
5 citations
5 citations
2434 days before retraction
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development
William G. Robichaux, Xiaodong Cheng
Physiological Reviews
Open Access
Published: Mar 2018
183 citations
183 citations
2680 days before retraction
Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment
Naveen Kumar, Peeyush Prasad, Eshna Jash et al. (7 authors)
Molecular and Cellular Biochemistry
Published: Feb 2018
33 citations
33 citations
2715 days before retraction
EPAC1 overexpression is a prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer
Ding‐Ping Sun, Chia-Lang Fang, Han‐Kun Chen et al. (8 authors)
Oncology Reports
Open Access
Published: Feb 2017
26 citations
26 citations
3073 days before retraction
Effect of Epac1 on pERK and VEGF Activation in Postoperative Persistent Pain in Rats
Su Cao, Zhen Bian, Xiang Zhu et al. (4 authors)
Journal of Molecular Neuroscience
Published: Jun 2016
9 citations
9 citations
3322 days before retraction
Paper citing Upregulation of mTORC2 Activation by the Selective...
Unknown Authors
Unknown Journal
Published: Apr 2016
3385 days before retraction
tPA promotes cortical neuron survival via mTOR-dependent mechanisms
Julia A. Grummisch, Nafisa M. Jadavji, Patrice D. Smith
Molecular and Cellular Neuroscience
Published: Mar 2016
16 citations
16 citations
3408 days before retraction
Paper citing Upregulation of mTORC2 Activation by the Selective...
Unknown Authors
Unknown Journal
Published: Jan 2016
3469 days before retraction
<scp>mTORC</scp> 2 sustains thermogenesis via Akt‐induced glucose uptake and glycolysis in brown adipose tissue
Verena Albert, Kristoffer Svensson, Mitsugu Shimobayashi et al. (9 authors)
EMBO Molecular Medicine
Open Access
Published: Jan 2016
121 citations
121 citations
3469 days before retraction
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
Mousumi Ghosh, Yong Xu, Damien D. Pearse
Journal of Neuroinflammation
Open Access
Published: Jan 2016
170 citations
170 citations
3471 days before retraction
The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention
Muayad F. Almahariq, Fang Mei, Xiaodong Cheng
Acta Biochimica et Biophysica Sinica
Open Access
Published: Dec 2015
33 citations
33 citations
3492 days before retraction
Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function
B.R. Lackey, Sandra L. Gray
General and Comparative Endocrinology
Published: Jul 2015
7 citations
7 citations
3652 days before retraction
Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics
Upasana Banerjee, Xiaodong Cheng
Gene
Open Access
Published: Jun 2015
60 citations
60 citations
3672 days before retraction
Activated α2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses
Uma Kant Misra, Salvatore V. Pizzo
Journal of Biological Chemistry
Open Access
Published: Feb 2015
27 citations
27 citations
3791 days before retraction
β-Adrenergic Receptor Signaling in Prostate Cancer
Peder R. Braadland, H. Ramberg, Helene Hartvedt Grytli et al. (4 authors)
Frontiers in Oncology
Open Access
Published: Jan 2015
66 citations
66 citations
3837 days before retraction
Dual Differential Roles of Cancerous Immunoglobulins as Suggested by Interactions with Human Serum Proteins
Gregory Lee
Journal of Clinical & Cellular Immunology
Published: Jan 2015
2 citations
2 citations
3848 days before retraction
Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo
Muayad F. Almahariq, Celia Chao, Fang Mei et al. (7 authors)
Molecular Pharmacology
Open Access
Published: Nov 2014
51 citations
51 citations
3900 days before retraction
Paper citing Upregulation of mTORC2 Activation by the Selective...
Unknown Authors
Unknown Journal
Published: Aug 2014
3982 days before retraction
Activated α2-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor
Uma Kant Misra, Salvatore V. Pizzo
PLoS ONE
Open Access
Published: Feb 2014
23 citations
23 citations
4177 days before retraction
Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain
Huijing Wang, Cobi J. Heijnen, Cindy T. J. van Velthoven et al. (10 authors)
Journal of Clinical Investigation
Open Access
Published: Nov 2013
94 citations
94 citations
4261 days before retraction
The Monomeric Receptor Binding Domain of Tetrameric α<sub>2</sub>-Macroglobulin Binds to Cell Surface GRP78 Triggering Equivalent Activation of Signaling Cascades
Uma Kant Misra, Sturgis Payne, Salvatore V. Pizzo
Biochemistry
Published: May 2013
13 citations
13 citations
4439 days before retraction
Evidence for a Pro-Proliferative Feedback Loop in Prostate Cancer: The Role of Epac1 and COX-2-Dependent Pathways
Uma Kant Misra, Salvatore V. Pizzo
PLoS ONE
Open Access
Published: Apr 2013
33 citations
33 citations
4459 days before retraction
Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions
Martina Schmidt, Frank J. Dekker, Harm Maarsingh
Pharmacological Reviews
Published: Feb 2013
258 citations
258 citations
4521 days before retraction
iTorin1—An Active Site Inhibitor of mTOR, Suppresses Prostate Cancer Cell Growth Induced by Activated α2M-Macroglobulin Ligation of Cell Surface GRP78
Uma Kant Misra, Salvatore V. Pizzo
Journal of Cancer Therapy
Open Access
Published: Jan 2013
1 citation
1 citation
4578 days before retraction
Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells
Uma Kant Misra, Salvatore V. Pizzo
PLoS ONE
Open Access
Published: Dec 2012
39 citations
39 citations
4596 days before retraction
A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion
Muayad F. Almahariq, Tamara Tsalkova, Fang Mei et al. (8 authors)
Molecular Pharmacology
Open Access
Published: Oct 2012
201 citations
201 citations
4660 days before retraction
Quick Stats
Total Citations:
41
Years Since Retraction:
<1 year
Open Access:
Yes
Last Checked:
Jul 23, 2025