Retraction

Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IκBα kinase-NFκB

Paper Information

Record ID:

29247

Author(s):

Chen Wang
Taoyong Chen
Ning Zhang
Mingjin Yang
Bai Li
Xiang Lu
Xuetao Cao

Journal:

The Journal of Biological Chemistry ( Elsevier )

Publication Date:

December 12, 2008

Retraction Date:

April 29, 2021 (4.6 years years ago)

Subjects:

Broad Categories:
Biology Biochemistry

Specific Fields:
Biochemistry Biology - Cancer Biology - Cellular

Institutions:

Country:

🇨🇳 China

Article Type:

Research Article

Publisher:

Elsevier

Open Access:

Yes

DOI:

10.1074/jbc.M807191200

PubMed ID:

19074436

Retraction PubMed ID:

Not indexed in PubMed

Retraction Details

Retraction Reasons:

Nature of Retraction:

Retraction

Retraction Notice:

10.1016/j.jbc.2021.100767

Citations (192)

192

Total Citations

41

Post-Retraction
(21.4%)

151

Pre-Retraction

0

Same Day

Post-Retraction Citation Analysis

0 Within 30 days

9 Within 1 year

24 After 2+ years

1489 Days since retraction (latest)

Anti-Inflammatory Effects of Bee Venom on Phthalic Anhydride-Induced Atopic Dermatitis

Myung Jin Oh, Ho Sueb Song

Journal of Acupuncture Research Open Access

Published: Feb 2020
2 citations

433 days before retraction

Apoptotic Effects of Melittin on 4T1 Breast Cancer Cell Line is associated with Up Regulation of Mfn1 and Drp1 mRNA Expression

Farnaz Dabbagh Moghaddam, Pejman Mortazavi, Somayeh Hamedi et al. (5 authors)

Anti-Cancer Agents in Medicinal Chemistry

Published: Feb 2020
50 citations

443 days before retraction

Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice

Nermeen M El Bakary, Asmaa Z. Alsharkawy, Zeinab A. Shouaib et al. (4 authors)

Integrative Cancer Therapies Open Access

Published: Jan 2020
34 citations

484 days before retraction

Use of Selected Carbon Nanoparticles as Melittin Carriers for MCF-7 and MDA-MB-231 Human Breast Cancer Cells

Karolina Daniluk, Marta Kutwin, Marta Grodzik et al. (11 authors)

Materials Open Access

Published: Dec 2019
37 citations

493 days before retraction

Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain

Zheng Yu-Xiang, Xiu‐Xiang Zhang, Jorge A. Hernández et al. (10 authors)

Parasites & Vectors Open Access

Published: Nov 2019
12 citations

538 days before retraction

Melittin inhibits proliferation, migration and invasion of bladder cancer cells by regulating key genes based on bioinformatics and experimental assays

Jie Yao, Zhan Zhang, Sheng Li et al. (5 authors)

Journal of Cellular and Molecular Medicine Open Access

Published: Nov 2019
24 citations

541 days before retraction

An overview of the bioactive compounds, therapeutic properties and toxic effects of apitoxin

Ananías Pascoal, María Manuela Estevinho, Altino Choupina et al. (5 authors)

Food and Chemical Toxicology Open Access

Published: Sep 2019
39 citations

579 days before retraction

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Rim Wehbe, Jacinthe Frangieh, Mohamad Rima et al. (6 authors)

Molecules Open Access

Published: Aug 2019
310 citations

619 days before retraction

Two/three-dimensional interfacial properties of the novel peptide as a selective destroyer of biomembrane

Sijia Wang, Mengya Li, Shouhong Xu et al. (4 authors)

Colloids and Surfaces A Physicochemical and Engineering Aspects

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2 citations

740 days before retraction

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Veerle Fleskens, Carlos M. Minutti, Xingmei Wu et al. (14 authors)

Cell Reports Open Access

Published: Mar 2019
40 citations

790 days before retraction

Peptides as Potential Anticancer Agents

Shams Aaghaz, Vivek Gohel, Ähmed Kamal

Current Topics in Medicinal Chemistry

Published: Jan 2019
36 citations

822 days before retraction

Smart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo

Rezvan Yazdian‐Robati, Atefeh Arab, Mohammad Ramezani et al. (8 authors)

Drug Development and Industrial Pharmacy

Published: Jan 2019
40 citations

839 days before retraction

Dual‐Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta–Activated Kinase 1 Suppression

Ping Ye, Jijun Liu, XU Wu-ping et al. (10 authors)

Hepatology Open Access

Published: Dec 2018
51 citations

857 days before retraction

Effect of Melittin on Metabolomic Profile and Cytokine Production in PMA-Differentiated THP-1 Cells

Abdulmalik M. Alqarni, Valerie A. Ferro, John A. Parkinson et al. (5 authors)

Vaccines Open Access

Published: Oct 2018
14 citations

929 days before retraction

Triggering of cancer cell cycle arrest by a novel scorpion venom‐derived peptide—Gonearrestide

Bin Li, Peng Lyu, Xinping Xi et al. (7 authors)

Journal of Cellular and Molecular Medicine Open Access

Published: Jul 2018
47 citations

1023 days before retraction

Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells

Abeer A. Khamis, Ehab M. M. Ali, Mohamed A. Abd El-Moneim et al. (6 authors)

Biomedicine & Pharmacotherapy

Published: Jun 2018
108 citations

1038 days before retraction

Anti-Tumor Effects of Melittin and Its Potential Applications in Clinic

Can Lyu, Fanfu Fang, Li Bai

Current Protein and Peptide Science

Published: Jun 2018
57 citations

1051 days before retraction

Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway

Sun Mi Gu, Hee Pom Lee, Young Wan Ham et al. (9 authors)

NeuroMolecular Medicine Open Access

Published: May 2018
35 citations

1070 days before retraction

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon et al. (10 authors)

BMC Cancer Open Access

Published: Apr 2018
5 citations

1109 days before retraction

Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells

Xiaotong Li, Hongqing Xie, Yajie Chen et al. (6 authors)

International Journal of Molecular Sciences Open Access

Published: Mar 2018
36 citations

1128 days before retraction

Antioxidant activity and irritation property of venoms from Apis species

Suvimol Somwongin, Panuwan Chantawannakul, Wantida Chaiyana

Toxicon

Published: Mar 2018
76 citations

1154 days before retraction

Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy

Yinglu Feng, Yongan Chen, Yongbin Meng et al. (7 authors)

OncoImmunology Open Access

Published: Jan 2018
29 citations

1199 days before retraction

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

Yan‐Xiao Ji, Zan Huang, Xia Yang et al. (24 authors)

Nature Medicine

Published: Jan 2018
134 citations

1214 days before retraction

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat

Keren Zhou, Budbazar Enkhjargal, Zhiyi Xie et al. (10 authors)

Stroke Open Access

Published: Dec 2017
78 citations

1224 days before retraction

Apoptotic Effect of Melittin Purified from Iranian Honey Bee Venom on Human Cervical Cancer HeLa Cell Line

Hannaneh Zarrinnahad, Amir Mahmoodzadeh, Monireh Parviz Hamidi et al. (7 authors)

International Journal of Peptide Research and Therapeutics Open Access

Published: Nov 2017
73 citations

1265 days before retraction

Evaluation of Efficiency of Modified Polypropylenimine (PPI) with Alkyl Chains as Non-viral Vectors Used in Co-delivery of Doxorubicin and TRAIL Plasmid

Mahboubeh Ebrahimian, Sahar Taghavi, Maryam Ghoreishi et al. (7 authors)

AAPS PharmSciTech

Published: Nov 2017
8 citations

1269 days before retraction

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Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy

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Antibodies Open Access

Published: Oct 2017
72 citations

1282 days before retraction

Paper citing Activation of NF-κB by alloferon through down-regu...

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1303 days before retraction

The anti‑hepatocellular carcinoma activity of Mel‑P15 is mediated by natural killer cells

Tao Xu, Tongxing Cui, Lipan Peng et al. (6 authors)

Oncology Letters Open Access

Published: Sep 2017
16 citations

1316 days before retraction

Exploration Through the Venoms from Hymenoptera as Potential Therapeutic Agents in Cancer Therapy

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International Journal of Pharmacology Open Access

Published: Jul 2017
6 citations

1384 days before retraction

Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer

Nana Pei, Yingying Mao, Pengfei Wan et al. (17 authors)

Journal of Experimental & Clinical Cancer Research Open Access

Published: Jun 2017
48 citations

1420 days before retraction

Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy

Islam Rady, Imtiaz A. Siddiqui, Mohamed I. Rady et al. (4 authors)

Cancer Letters Open Access

Published: May 2017
328 citations

1440 days before retraction

The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-κB, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp ( Ctenopharyngodon idella )

Yanlin Guo, Wei‐Dan Jiang, Pei Wu et al. (10 authors)

Fish & Shellfish Immunology

Published: Apr 2017
68 citations

1472 days before retraction

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

Berthony Deslouches, Y. Peter Di

Oncotarget Open Access

Published: Mar 2017
348 citations

1490 days before retraction

Anticancer potential of bioactive peptides from animal sources

Linghong Wang, Chao Dong, Xian Li et al. (5 authors)

Oncology Reports Open Access

Published: Feb 2017
116 citations

1548 days before retraction

Calmodulin Binding to Death Receptor 5-mediated Death-Inducing Signaling Complex in Breast Cancer Cells

Romone M. Fancy, Harrison Kim, Tong Zhou et al. (6 authors)

Journal of Cellular Biochemistry Open Access

Published: Jan 2017
9 citations

1564 days before retraction

Design, synthesis, and antiproliferative activities of stapled melittin peptides

Ye Wu, Mengfei Han, Chao Liu et al. (8 authors)

RSC Advances Open Access

Published: Jan 2017
20 citations

1579 days before retraction

Application of bee venom and its main constituent melittin for cancer treatment

Cuicui Liu, Dingjun Hao, Qian Zhang et al. (8 authors)

Cancer Chemotherapy and Pharmacology

Published: Sep 2016
88 citations

1675 days before retraction

Finishing monkeypox genomes from short reads: assembly analysis and a neural network method

Kun Zhao, Robert M. Wohlhueter, Li Yu

BMC Genomics Open Access

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8 citations

1732 days before retraction

Insect antimicrobial peptides: potential tools for the prevention of skin cancer

Miray Tonk, Andreas Vilcinskas, Mohammad Rahnamaeian

Applied Microbiology and Biotechnology Open Access

Published: Jul 2016
71 citations

1750 days before retraction

Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development

Juan Wang, Guixiang Tai

Targeted Oncology

Published: Jul 2016
40 citations

1756 days before retraction

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

Mingjun Liu, Haitao Wang, Linjie Liu et al. (5 authors)

Journal of Translational Medicine Open Access

Published: May 2016
46 citations

1794 days before retraction

From a pro-apoptotic peptide to a lytic peptide: One single residue mutation

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Biochimica et Biophysica Acta (BBA) - Biomembranes

Published: May 2016
32 citations

1808 days before retraction

Characterization of the Interactions between Calmodulin and Death Receptor 5 in Triple-negative and Estrogen Receptor-positive Breast Cancer Cells

Romone M. Fancy, Lingyun Wang, Qinghua Zeng et al. (7 authors)

Journal of Biological Chemistry Open Access

Published: Apr 2016
16 citations

1832 days before retraction

Bee Venom and Its Therapeutic Values: A Review

Nejash Abdela Kula Jilo

Advances in life science and technology

Published: Jan 2016
17 citations

1945 days before retraction

Melittin induces human gastric cancer cell apoptosisviaactivation of mitochondrial pathway

Guimei Kong, Tao Wenhua, Yali Diao et al. (7 authors)

World Journal of Gastroenterology Open Access

Published: Jan 2016
82 citations

1945 days before retraction

Melittin induced cytogenetic damage, oxidative stress and changes in gene expression in human peripheral blood lymphocytes

Goran Gajski, Ana‐Marija Domijan, Bojana Žegura et al. (11 authors)

Toxicon

Published: Dec 2015
76 citations

1959 days before retraction

Bee venom acupuncture alleviates trimellitic anhydride-induced atopic dermatitis-like skin lesions in mice

Bongjun Sur, Bombi Lee, Mijung Yeom et al. (10 authors)

BMC Complementary and Alternative Medicine Open Access

Published: Dec 2015
25 citations

1976 days before retraction

Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris

Manman Su, Weiqin Chang, Kun Zhang et al. (6 authors)

Oncology Reports Open Access

Published: Nov 2015
18 citations

1982 days before retraction

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This article has multiple records in the database due to different notices:

Record #29248

Jun 26, 2020

Expression of concern

Quick Stats

Total Citations: 192

Years Since Retraction: 4.6 years

Open Access: Yes

Last Checked: Jul 24, 2025

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