Retraction

Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IκBα kinase-NFκB

Paper Information

Record ID:
29247
Author(s):
Chen Wang
Taoyong Chen
Ning Zhang
Mingjin Yang
Bai Li
Xiang Lu
Xuetao Cao
Journal:
The Journal of Biological Chemistry ( Elsevier )
Publication Date:
December 12, 2008
Retraction Date:
April 29, 2021 (4.6 years years ago)
Subjects:
Broad Categories:
Biology Biochemistry
Institutions:
Country:
🇨🇳 China
Article Type:
Research Article
Publisher:
Elsevier
Open Access:
Yes
DOI:
10.1074/jbc.M807191200
PubMed ID:
19074436
Retraction PubMed ID:
Not indexed in PubMed

Retraction Details

Retraction Reasons:
Nature of Retraction:

Retraction

Retraction Notice:
10.1016/j.jbc.2021.100767

Citations (192)

192
Total Citations
41
Post-Retraction
(21.4%)
151
Pre-Retraction
0
Same Day
Post-Retraction Citation Analysis
0 Within 30 days
9 Within 1 year
24 After 2+ years
1489 Days since retraction (latest)
Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B
Jie Zheng, Hye Lim Lee, Young Wan Ham et al. (6 authors)
Oncotarget Open Access
Published: Oct 2015
58 citations
2008 days before retraction
Panaxydol, a component of<i>Panax ginseng</i>, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models
Hee Suk Kim, Jang Mi Lim, Joo Young Kim et al. (6 authors)
International Journal of Cancer Open Access
Published: Sep 2015
49 citations
2038 days before retraction
First report on the isolation of melittin from Iranian honey bee venom and evaluation of its toxicity on gastric cancer AGS cells
Amir Mahmoodzadeh, Hannaneh Zarrinnahad, Kamran Pooshang Bagheri et al. (5 authors)
Journal of the Chinese Medical Association Open Access
Published: Aug 2015
42 citations
2074 days before retraction
Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy
Alaa Refaat, Sherif Abdelhamed, Ikuo Saiki et al. (4 authors)
Oncology Letters Open Access
Published: Jul 2015
26 citations
2115 days before retraction
Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo
Dingding Wang, Lili Hu, Manman Su et al. (5 authors)
International Journal of Oncology Open Access
Published: Jul 2015
16 citations
2121 days before retraction
Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway
Sun Mi Gu, Mi Hee Park, Chul Ju Hwang et al. (11 authors)
Journal of Neuroinflammation Open Access
Published: Jun 2015
67 citations
2135 days before retraction
The emerging role of CaMKII in cancer
Yanyang Wang, Ren Zhao, Hong Zhe
Oncotarget Open Access
Published: Apr 2015
102 citations
2192 days before retraction
The Growth and Aggressive Behavior of Human Osteosarcoma Is Regulated by a CaMKII-Controlled Autocrine VEGF Signaling Mechanism
Paul G. Daft, Yang Yang, Dobrawa Napierala et al. (4 authors)
PLoS ONE Open Access
Published: Apr 2015
25 citations
2211 days before retraction
Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy
Xiaoyun Dai, Jingwen Zhang, Frank Arfuso et al. (9 authors)
Experimental Biology and Medicine Open Access
Published: Apr 2015
177 citations
2214 days before retraction
Glochidioboside Kills Pathogenic Bacteria by Membrane Perturbation
Heejeong Lee, Eun‐Rhan Woo, Dong Gun Lee
Current Microbiology
Published: Mar 2015
11 citations
2223 days before retraction
CecropinXJ inhibits the proliferation of human gastric cancer BGC823 cells and induces cell death in vitro and in vivo
Yanling Wu, Lijie Xia, Jinyao Li et al. (4 authors)
International Journal of Oncology Open Access
Published: Mar 2015
27 citations
2234 days before retraction
Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens
Luís Fernando Leandro, Carlos A. Mendes, Luciana Assirati Casemiro et al. (7 authors)
Anais da Academia Brasileira de Ciências Open Access
Published: Mar 2015
96 citations
2251 days before retraction
Bee venom inhibits growth of human cervical tumors in mice
Hye Lim Lee, Sang Ho Park, Tae Myoung Kim et al. (14 authors)
Oncotarget Open Access
Published: Jan 2015
15 citations
2288 days before retraction
The pharmaceutical Impacts of honeybee venom against thioacetamide-induced hepatic fibrosis in rats
Attalla F. El‐kott, K.M. Mohanny
Advances in life science and technology
Published: Jan 2015
1 citation
2310 days before retraction
Triple-controlled oncolytic adenovirus expressing melittin to exert inhibitory efficacy on hepatocellular carcinoma.
Chun-Yu Qian, Kaili Wang, Fanfu Fang et al. (8 authors)
PubMed
Published: Jan 2015
27 citations
2310 days before retraction
Melittin exerts antitumorigenic effects in human MM1.S multiple myeloma cells through the suppression of AKT/mTOR/S6K1/4E-BP1 signaling cascades
Chulwon Kim, Dong Sub Kim, Dongwoo Nam et al. (6 authors)
Oriental Pharmacy and Experimental Medicine
Published: Nov 2014
4 citations
2353 days before retraction
Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells
Kyung Un Choi, Chul Ju Hwang, Gu Sun et al. (12 authors)
Toxins Open Access
Published: Jul 2014
66 citations
2470 days before retraction
Hepatocellular carcinoma: targeting of oncogenic signaling networks in TRAIL resistant cancer cells
Sundas Fayyaz, İlhan Yaylım, Saime Turan et al. (5 authors)
Molecular Biology Reports
Published: Jul 2014
9 citations
2477 days before retraction
Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis
Seong Cheol Ko, Ho Sueb Song
The Acupuncture Open Access
Published: Jun 2014
2 citations
2505 days before retraction
Melittin radiosensitizes esophageal squamous cell carcinoma with induction of apoptosis in vitro and in vivo
Hongcheng Zhu, Xi Yang, Jia Liu et al. (14 authors)
Tumor Biology
Published: May 2014
20 citations
2528 days before retraction
Review of the anticancer activities of bee products
Pongsathon Premratanachai, Chanpen Chanchao
Asian Pacific Journal of Tropical Biomedicine Open Access
Published: Apr 2014
132 citations
2576 days before retraction
Melittin Ameliorates the Inflammation of Organs in an Amyotrophic Lateral Sclerosis Animal Model
Sun Hwa Lee, Sun-Mi Choi, Eun Jin Yang
Experimental Neurobiology Open Access
Published: Mar 2014
30 citations
2587 days before retraction
Melittin suppresses EGF-induced cell motility and invasion by inhibiting PI3K/Akt/mTOR signaling pathway in breast cancer cells
Yun‐Jeong Jeong, Yong-Soo Choi, Jae-Moon Shin et al. (12 authors)
Food and Chemical Toxicology
Published: Mar 2014
128 citations
2592 days before retraction
The use of versatile plant antimicrobial peptides in agribusiness and human health
Elizabete de Souza Cândido, Marlon H. Cardoso, Daniel Amaro Sousa et al. (7 authors)
Peptides
Published: Feb 2014
122 citations
2629 days before retraction
Sensitization of Hepatocellular Carcinoma Cells to <scp>A</scp>po2<scp>L</scp>/<scp>TRAIL</scp> by a Novel Akt/<scp>NF</scp>‐κ<scp>B</scp> Signalling Inhibitor
Hany A. Omar, El‐Shaimaa A. Arafa, Ibrahim A. Maghrabi et al. (4 authors)
Basic & Clinical Pharmacology & Toxicology
Published: Jan 2014
28 citations
2668 days before retraction
Co-culture with NK-92MI cells enhanced the anti-cancer effect of bee venom on NSCLC cells by inactivation of NF-κB
Pushpa Saranya Kollipara, Jung‐Hyun Kim, Dohee Won et al. (12 authors)
Archives of Pharmacal Research
Published: Dec 2013
13 citations
2676 days before retraction
Dual‐Functional PEI–Poly(γ‐Cholesterol‐<scp>l</scp>‐Glutamate) Copolymer for Drug/Gene Co‐delivery
Jinkun Zhang, Dailong Fang, Qing Ma et al. (11 authors)
Macromolecular Chemistry and Physics
Published: Nov 2013
10 citations
2713 days before retraction
Cytotoxicity of melittin and apamin in human hepatic L02 and HepG2 cells<i>in vitro</i>
Jinhui Zhou, Yitao Qi, Qingyun Diao et al. (7 authors)
Toxin Reviews
Published: Oct 2013
17 citations
2744 days before retraction
Isolating Melittin from Bee Venom and Evaluating its Effect on Proliferation of Gastric Cancer Cells
Amir Mahmoodzadeh, Ali Morady, Hannaneh Zarrinnahad et al. (8 authors)
Basic & Clinical Cancer Research
Published: Oct 2013
4 citations
2767 days before retraction
A Neural-network Algorithm for All k Shortest Paths Problem
Kun Zhao, Abdoul Sylla
Unknown Journal
Published: Sep 2013
1 citation
2776 days before retraction
Effects of cosmetics containing purified honeybee (Apis mellifera L.) venom on acne vulgaris
Sang Mi Han, Kwang Gill Lee, Sok Cheon Pak
Journal of Integrative Medicine
Published: Sep 2013
45 citations
2797 days before retraction
Oxyphenisatin acetate (<scp>NSC</scp>59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine<scp>TNF</scp>α‐mediated apoptosis
Bethanie L. Morrison, Michael E. Mullendore, Luke H. Stockwin et al. (6 authors)
Cancer Medicine Open Access
Published: Jul 2013
14 citations
2837 days before retraction
Melittin: A lytic peptide with anticancer properties
Goran Gajski, Vera Garaj‐Vrhovac
Environmental Toxicology and Pharmacology
Published: Jun 2013
279 citations
2862 days before retraction
Comparative proteome analysis of Tumor necrosis factor α-stimulated human Vascular Smooth Muscle Cells in response to melittin
Hyun-Ji Cho, Jeong Han Kang, Kwan‐Kyu Park et al. (13 authors)
Proteome Science Open Access
Published: May 2013
11 citations
2914 days before retraction
Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways
Camila M. Adade, Isabelle Rocha Oliveira, Joana A.R. Pais et al. (4 authors)
Toxicon Open Access
Published: Apr 2013
82 citations
2949 days before retraction
Isolation of melittin from bee venom and evaluation of its effect on proliferation of gastric cancer cells
Amir Mahmoodzadeh, Ali Morady, Hannaneh Zarrinnahad et al. (8 authors)
DOAJ (DOAJ: Directory of Open Access Journals)
Published: Mar 2013
4 citations
2981 days before retraction
A novel melittin-MhIL-2 fusion protein inhibits the growth of human ovarian cancer SKOV3 cells in vitro and in vivo tumor growth
Mingjun Liu, Jinbao Zong, Zimin Liu et al. (7 authors)
Cancer Immunology Immunotherapy Open Access
Published: Feb 2013
23 citations
2984 days before retraction
Inhibitory Effect of Snake Venom Toxin on Colorectal Cancer HCT116 Cells Growth through Induction of Intrinsic or Extrinsic Apoptosis&amp;lt;sup&amp;gt;※&amp;lt;/sup&amp;gt;
Kyung Tae Kim, Ho Sueb Song
The Acupuncture
Published: Feb 2013
3 citations
2990 days before retraction
Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides
Kelly C.L. Mulder, Loiane Alves de Lima, Vívian de Jesus Miranda et al. (5 authors)
Frontiers in Microbiology Open Access
Published: Jan 2013
191 citations
3040 days before retraction
Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli
Hongyan Liu, Yangyang Han, Haiyan Fu et al. (8 authors)
Applied Microbiology and Biotechnology
Published: Nov 2012
30 citations
3090 days before retraction
Melittin Suppresses VEGF-A-Induced Tumor Growth by Blocking VEGFR-2 and the COX-2-Mediated MAPK Signaling Pathway
Jeong‐Eun Huh, Jung Won Kang, Dongwoo Nam et al. (7 authors)
Journal of Natural Products
Published: Oct 2012
58 citations
3103 days before retraction
Programmable nanoparticle functionalization for<i>in vivo</i>targeting
Hua Pan, Jacob W. Myerson, Lingzhi Hu et al. (13 authors)
The FASEB Journal Open Access
Published: Oct 2012
63 citations
3124 days before retraction
Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins
Mi Hee Park, Miran Jo, Dohee Won et al. (6 authors)
APOPTOSIS
Published: Sep 2012
20 citations
3139 days before retraction
Expression and functional role of vacuolar H+-ATPase in human hepatocellular carcinoma
Jingyu Xu, Rui Xie, Xingguang Liu et al. (12 authors)
Carcinogenesis
Published: Sep 2012
70 citations
3156 days before retraction
Predicting Ca<sup>2+</sup>‐binding sites using refined carbon clusters
Kun Zhao, Xue Wang, Hing C. Wong et al. (7 authors)
Proteins Structure Function and Bioinformatics Open Access
Published: Jul 2012
16 citations
3194 days before retraction
Skin sensitization study of bee venom (<i>Apis mellifera</i>L.) in guinea pigs and rats
Sang Mi Han, Kwang Gill Lee, Kwan Kyu Park et al. (4 authors)
Cutaneous and Ocular Toxicology
Published: Jul 2012
20 citations
3205 days before retraction
<i>Apis mellifera</i>venom induces different cell death pathways in<i>Trypanosoma cruzi</i>
Camila M. Adade, GABRIELA S. F. CHAGAS, Thaïs Souto-Padrón
Parasitology
Published: Jul 2012
30 citations
3206 days before retraction
Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4α in Vitro and in Vivo
Zhenhuan Zhao, Wei Hong, Zhengyang Zeng et al. (8 authors)
Journal of Biological Chemistry Open Access
Published: Jul 2012
70 citations
3212 days before retraction
Acute Dermal Toxicity Study of Bee Venom (Apis mellifera L.) in Rats
Sang-Mi Han, Gwang-Gill Lee, Kwan Kyu Park
Toxicological Research Open Access
Published: Jun 2012
23 citations
3225 days before retraction
Alterations of GSH and MDA levels and their association with bee venom‐induced DNA damage in human peripheral blood leukocytes
Goran Gajski, Ana‐Marija Domijan, Vera Garaj‐Vrhovac
Environmental and Molecular Mutagenesis
Published: Jun 2012
28 citations
3230 days before retraction
Related Records

This article has multiple records in the database due to different notices:

Record #29248
Jun 26, 2020
Expression of concern
Quick Stats
Total Citations: 192
Years Since Retraction: 4.6 years
Open Access: Yes
Last Checked: Jul 24, 2025
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