Expression of concern
Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor–G protein coupling and Gβγ signaling
Paper Information
Record ID:
36326
Author(s):
Journal:
Neuroscience
(
Elsevier
)
Publication Date:
August 05, 2005
Retraction Date:
December 20, 2021
(3.9 years years ago)
Subjects:
Institutions:
- Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA
- Department of Psychology, Queen's University, Kingston, Ontario, K7L 3N6 Canada
- Pain Therapeutics, Inc., 416 Browning Way, South San Francisco, CA 94080, USA
Countries:
Article Type:
Publisher:
Elsevier
Open Access:
Yes
PubMed ID:
Retraction PubMed ID:
Expression of concern Details
Retraction Reason:
Nature of Retraction:
Expression of concern
Retraction Notice:
10.1016/j.neuroscience.2021.11.019Citations (172)
172
Total Citations12
Post-Retraction(7.0%)
159
Pre-Retraction0
Same DayPost-Retraction Citation Analysis
0
Within 30 days
3
Within 1 year
5
After 2+ years
1167
Days since retraction (latest)
Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways
Ying Liu, Yang Yang, Richard J. Ward et al. (7 authors)
Biochemical Journal
Published: Aug 2015
19 citations
19 citations
2314 days before retraction
Development of opioid-induced constipation: post hoc analysis of data from a 12-week prospective, open-label, blinded-endpoint streamlined study in low-back pain patients treated with prolonged-release WHO step III opioids
Michael A. Ueberall, Gerhard Mueller-Schwefe
Journal of Pain Research
Open Access
Published: Aug 2015
14 citations
14 citations
2333 days before retraction
A randomized clinical trial of the effects of ultra‐low‐dose naloxone infusion on postoperative opioid requirements and recovery
Ying Xiao, Linxin Wu, Qian Zhou et al. (6 authors)
Acta Anaesthesiologica Scandinavica
Published: Jun 2015
23 citations
23 citations
2391 days before retraction
Safety and efficacy of oxycodone/naloxone vs. oxycodone vs. morphine for the treatment of chronic low back pain: results of a 12 week prospective, randomized, open-label blinded endpoint streamlined study with prolonged-release preparations
Michael A. Ueberall, Gerhard Mueller-Schwefe
Current Medical Research and Opinion
Published: May 2015
32 citations
32 citations
2421 days before retraction
Naloxone added to bupivacaine or bupivacaine–fentanyl prolongs motor and sensory block during supraclavicular brachial plexus blockade: a randomized clinical trial
Sayed Mahdi Marashi, Hamidreza Sharifnia, Omid Azimaraghi et al. (6 authors)
Acta Anaesthesiologica Scandinavica
Published: Apr 2015
10 citations
10 citations
2427 days before retraction
(+)-Naloxone inhibits morphine-induced chemotaxis via prevention of heat shock protein 90 cleavage in microglia
Ru‐Yin Tsai, Yu‐Che Cheng, Chih‐Shung Wong
Journal of the Formosan Medical Association
Published: Jan 2015
19 citations
19 citations
2515 days before retraction
Ultralow Dose of Naloxone as an Adjuvant to Intrathecal Morphine Infusion Improves Perceived Quality of Sleep but Fails to Alter Persistent Pain
Linda Block, Christopher Lundborg, Jan Bjersing et al. (6 authors)
Clinical Journal of Pain
Open Access
Published: Jan 2015
19 citations
19 citations
2518 days before retraction
Endocannabinoids and epilepsy
Robert E. Blair, Laxmikant S. Deshpande, Robert J. DeLorenzo
Elsevier eBooks
Open Access
Published: Jan 2015
7 citations
7 citations
2545 days before retraction
An Evaluation of Factors Related to Postoperative Pain Control in Burn Patients
Lucy Wibbenmeyer, Anas Eid, Karen Kluesner et al. (7 authors)
Journal of Burn Care & Research
Published: Jan 2015
22 citations
22 citations
2545 days before retraction
μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids
Marino Convertino, Alexander Samoshkin, Josée Gauthier et al. (7 authors)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Open Access
Published: Dec 2014
27 citations
27 citations
2571 days before retraction
Chronic loss of noradrenergic tone produces β‐arrestin2‐mediated cocaine hypersensitivity and alters cellular <scp>D</scp>2 responses in the nucleus accumbens
Meriem Gaval‐Cruz, Richard Brandon Goertz, Daniel J. Puttick et al. (9 authors)
Addiction Biology
Open Access
Published: Aug 2014
11 citations
11 citations
2686 days before retraction
Actin Filament Reorganization in Astrocyte Networks is a Key Functional Step in Neuroinflammation Resulting in Persistent Pain: Novel Findings on Network Restoration
Elisabeth Hansson
Neurochemical Research
Published: Jun 2014
27 citations
27 citations
2740 days before retraction
Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP
Michal Bajo, Samuel G. Madamba, Marisa Roberto et al. (4 authors)
Frontiers in Integrative Neuroscience
Open Access
Published: Jun 2014
26 citations
26 citations
2756 days before retraction
Combined administration of oxycodone/naloxone in chronic osteo-articular diseases pain therapy.
R Palomba, Miralto Federica, Annamaria Vinciguerra et al. (5 authors)
PubMed
Published: Apr 2014
1 citation
1 citation
2820 days before retraction
Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau
Yuan Jiang, Ni Li, Heping Zhang
Journal of the American Statistical Association
Open Access
Published: Mar 2014
9 citations
9 citations
2834 days before retraction
Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins
Kalindi Bakshi, Raminder Parihar, Satindra Goswami et al. (6 authors)
PLoS ONE
Open Access
Published: Mar 2014
11 citations
11 citations
2839 days before retraction
Combining an oral opioid-receptor agonist and the antagonist naloxone: A smart drug design that removes some but not all adverse effects of the opioid analgesic
Harald Breivik, Mads U. Werner
Scandinavian Journal of Pain
Published: Mar 2014
6 citations
6 citations
2846 days before retraction
A novel controlled release drug delivery system for naltrexone administration combined with intermittent morphine to induce antinociception
Abbas Norouzi‐Javidan, Forooza Samadi, Sahar Latifi et al. (5 authors)
Journal of Drug Delivery Science and Technology
Published: Jan 2014
3 citations
3 citations
2910 days before retraction
ENHANCING PERIPHERAL OPIOID ANALGESIA: DEVELOPMENT OF VIRAL VECTOR AND SMALL PEPTIDE THERAPIES
Sherika Smith
Unknown Journal
Published: Jan 2014
2910 days before retraction
Ultra-low dose (+)-naloxone restores the thermal threshold of morphine tolerant rats
Kuang-Yi Chou, Ru‐Yin Tsai, Wei‐Yuan Tsai et al. (7 authors)
Journal of the Formosan Medical Association
Open Access
Published: Dec 2013
8 citations
8 citations
2941 days before retraction
Inhibitory effect of spinal mGlu5 receptor antisense oligonucleotide on the up-regulated expression of spinal G protein associated with chronic morphine treatment
Moxi Chen, Xiaoli Zhang, Hao Xu et al. (6 authors)
European Journal of Pharmacology
Published: Dec 2013
6 citations
6 citations
2941 days before retraction
Intrathecal Ultra-Low Dose Naloxone Enhances the Antihyperalgesic Effects of Morphine and Attenuates Tumor Necrosis Factor-α and Tumor Necrosis Factor-α Receptor 1 Expression in the Dorsal Horn of Rats with Partial Sciatic Nerve Transection
Chih-Ping Yang, Chen‐Hwan Cherng, Ching‐Tang Wu et al. (7 authors)
Anesthesia & Analgesia
Open Access
Published: Nov 2013
21 citations
21 citations
2951 days before retraction
Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn
D. Wang, T. Chen, Xincan Zhou et al. (5 authors)
Neuroscience
Published: Sep 2013
22 citations
22 citations
3019 days before retraction
A new concept affecting restoration of inflammation-reactive astrocytes
Linda Block, Ulrika Björklund, Anna Westerlund et al. (6 authors)
Neuroscience
Open Access
Published: Jul 2013
37 citations
37 citations
3070 days before retraction
Nitric Oxide in the Hippocampal Cortical Area 1 (CA1) Augments the Naloxone-induced Place Aversion
Masoomeh Pirouzi, Manizheh Karami, Mohammadreza Jalali Nadoushan
Journal of Biological Sciences
Open Access
Published: Jul 2013
3079 days before retraction
OPIOIDS AND GLIA: INVESTIGATING THE MECHANISMS THROUGH WHICH ULTRA-LOW DOSE OPIOID ANTAGONISTS MODULATE OPIOID TOLERANCE AND HYPERALGESIA.
Theresa Alexandra Mattioli
Unknown Journal
Published: Apr 2013
3161 days before retraction
Oxycodone combined with opioid receptor antagonists: efficacy and safety
Mellar P. Davis, Harold W. Goforth, Pam Gamier
Expert Opinion on Drug Safety
Published: Mar 2013
20 citations
20 citations
3189 days before retraction
Opioid antagonists for pain
Robert Taylor, Joseph V. Pergolizzi, Frank Porreca et al. (4 authors)
Expert Opinion on Investigational Drugs
Published: Mar 2013
16 citations
16 citations
3204 days before retraction
The stereoisomer (+)-naloxone potentiates G-protein coupling and feeding associated with stimulation of mu opioid receptors in the parabrachial nucleus
Nayla Chaijale, Vincent J. Aloyo, Kenny J. Simansky
Journal of Psychopharmacology
Published: Jan 2013
8 citations
8 citations
3252 days before retraction
Challenges for Pain Management in the Twenty-First Century
Mellar P. Davis
Springer eBooks
Published: Jan 2013
3275 days before retraction
Pacjent z opornym bólem, leczony dużymi dawkami opioidów. Czy możemy uniknąć zwiększania dawki opioidów?
Piotr Sobański, Małgorzata Krajnik, Lucas Ritz et al. (6 authors)
Palliative Medicine in Practice
Published: Jan 2013
3275 days before retraction
Endorphinergic Attenuation of Distress by Concomitantly Enhancing Endogenous Opioid Release and Switching Opioid Receptor Signaling from an Excessively Excitatory to a Normal Inhibitory Mode
Steven Crain, Stanley M. Crain
Journal of Behavioral and Brain Science
Open Access
Published: Jan 2013
1 citation
1 citation
3275 days before retraction
Methadone Hyperalgesia
Peggy Compton
Springer eBooks
Published: Jan 2013
3275 days before retraction
Studies on the Role of G Protein Alpha Subunits in Opioid Signaling and Behavior.
Jennifer T. Lamberts
Deep Blue (University of Michigan)
Open Access
Published: Jan 2013
3275 days before retraction
Abuse-deterrent and tamper-resistant opioids: how valuable are novel formulations in thwarting non-medical use?
L. Lourenco, Michele L. Matthews, Robert N. Jamison
Expert Opinion on Drug Delivery
Published: Dec 2012
22 citations
22 citations
3287 days before retraction
A patient with intractable pain on high dose opioid therapy. Could we manage not to escalate the opioid dose
Piotr Sobański, Małgorzata Krajnik, Lucas Ritz et al. (6 authors)
Advances in Palliative Medicine
Published: Nov 2012
3335 days before retraction
Naloxone in ultralow concentration restores endomorphin-1–evoked Ca2+ signaling in lipopolysaccharide pretreated astrocytes
Linda Block, Johan Forshammar, Anna Westerlund et al. (7 authors)
Neuroscience
Published: Jan 2012
17 citations
17 citations
3633 days before retraction
Evidence from basic research for opioid combinations
Mellar P. Davis
Expert Opinion on Drug Discovery
Published: Jan 2012
15 citations
15 citations
3638 days before retraction
Nitric oxide in the hippocampal cortical area interacts with naloxone in inducing pain
Manizheh Karami, ZahraK Hafeshjani, Masoomeh Biglarnia
Indian Journal of Pharmacology
Open Access
Published: Jan 2012
5 citations
5 citations
3641 days before retraction
Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine‐induced adenylyl cyclase sensitization but not mitogen‐activated protein kinase phosphorylation
Mohammad Seyedabadi, Seyed Nasser Ostad, Paul R. Albert et al. (7 authors)
FEBS Journal
Open Access
Published: Dec 2011
9 citations
9 citations
3654 days before retraction
Contribution of G inhibitory protein alpha subunits in paradoxical hyperalgesia elicited by exceedingly low doses of morphine in mice
Enrica Bianchi, Nicoletta Galeotti, Cristina Menicacci et al. (4 authors)
Life Sciences
Open Access
Published: Oct 2011
9 citations
9 citations
3719 days before retraction
Intrathecal Ultra-Low Dose Naloxone Enhances the Antinociceptive Effect of Morphine by Enhancing the Reuptake of Excitatory Amino Acids from the Synaptic Cleft in the Spinal Cord of Partial Sciatic Nerve–Transected Rats
Chih-Ping Yang, Chen‐Hwan Cherng, Ching‐Tang Wu et al. (6 authors)
Anesthesia & Analgesia
Open Access
Published: Oct 2011
44 citations
44 citations
3730 days before retraction
The Optimal Dose of Prophylactic Intravenous Naloxone in Ameliorating Opioid-Induced Side Effects in Children Receiving Intravenous Patient-Controlled Analgesia Morphine for Moderate to Severe Pain
Constance L. Monitto, Sabine Kost‐Byerly, Elizabeth White et al. (7 authors)
Anesthesia & Analgesia
Open Access
Published: Oct 2011
53 citations
53 citations
3733 days before retraction
Can repeated exposure to morphine change the spinal analgesic effects of lidocaine in rats?
Ali Dabbagh, Shervin Farkhondehkish Moghadam, Samira Rajaei et al. (5 authors)
PubMed
Published: Oct 2011
8 citations
8 citations
3733 days before retraction
Paper citing Ultra-low-dose naloxone suppresses opioid toleranc...
Unknown Authors
Unknown Journal
Published: Sep 2011
3763 days before retraction
Acute Pain Management in Opioid-Tolerant Patients: A Growing Challenge
C. A. Huxtable, Lindy J. Roberts, Andrew A. Somogyi et al. (4 authors)
Anaesthesia and Intensive Care
Open Access
Published: Sep 2011
221 citations
221 citations
3763 days before retraction
Functional Selectivity at the μ-Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance
Kirsten M. Raehal, Cullen L. Schmid, Chad E. Groer et al. (4 authors)
Pharmacological Reviews
Open Access
Published: Aug 2011
246 citations
246 citations
3769 days before retraction
Paper citing Ultra-low-dose naloxone suppresses opioid toleranc...
Unknown Authors
Unknown Journal
Published: Aug 2011
3794 days before retraction
Current status and evolving role of abuse-deterrent opioids in managing patients with chronic pain
Lynn R. Webster, Barbara St. Marie, Bill McCarberg et al. (6 authors)
Journal of Opioid Management
Published: Jul 2011
41 citations
41 citations
3800 days before retraction
Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling
Jason R. Goldsmith, Joshua M. Uronis, Christian Jobin
American Journal Of Pathology
Open Access
Published: Jun 2011
45 citations
45 citations
3829 days before retraction
Quick Stats
Total Citations:
172
Years Since Retraction:
3.9 years
Open Access:
Yes
Last Checked:
Jul 24, 2025