Expression of concern

Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor–G protein coupling and Gβγ signaling

Paper Information

Record ID:
36326
Author(s):
Hoau Yan Wang
Eitan Friedman
M C Olmstead
Lindsay H Burns
Journal:
Neuroscience ( Elsevier )
Publication Date:
August 05, 2005
Retraction Date:
December 20, 2021 (3.9 years years ago)
Subjects:
Broad Categories:
Biology Biochemistry Toxicology
Institutions:
Countries:
🇨🇦 Canada 🇺🇸 United States
Article Type:
Research Article
Publisher:
Elsevier
Open Access:
Yes
DOI:
10.1016/j.neuroscience.2005.06.003
PubMed ID:
16084657
Retraction PubMed ID:
35031084

Expression of concern Details

Retraction Reason:

Concerns/Issues About Image

Nature of Retraction:

Expression of concern

Retraction Notice:
10.1016/j.neuroscience.2021.11.019

Citations (172)

172
Total Citations
12
Post-Retraction
(7.0%)
159
Pre-Retraction
0
Same Day
Post-Retraction Citation Analysis
0 Within 30 days
3 Within 1 year
5 After 2+ years
1167 Days since retraction (latest)
Immunohistochemical localization of mu opioid receptor in the marginal division with comparison to patches in the neostriatum of the rat brain
Chuanxing Wang, Si Yun Shu, Zhouyi Guo et al. (9 authors)
Journal of Biomedical Science Open Access
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12 citations
3855 days before retraction
Opioid tolerance and hyperalgesia: basic mechanisms and management in review
Mellar P. Davis
Progress in Palliative Care
Published: Mar 2011
2 citations
3947 days before retraction
Quantitative Detection of μ Opioid Receptor: Western Blot Analyses Using µ Opioid Receptor Knockout Mice
Shinya Kasai, Hideko Yamamoto, Etsuko Kamegaya et al. (7 authors)
Current Neuropharmacology Open Access
Published: Mar 2011
12 citations
3947 days before retraction
Blockade of the Naloxone-induced Aversion in Morphine-conditioned Wistar Rats by L-Arginine Intra-central Amygdala
Mahnaz Rahimpour, Manizheh Karami, Sara Karimi et al. (6 authors)
DOAJ (DOAJ: Directory of Open Access Journals)
Published: Mar 2011
3 citations
3947 days before retraction
Opioids in chronic non-cancer pain
Bob Kwok Bun Chan, Lee Ka Tam, Chun Yin Wat et al. (6 authors)
Expert Opinion on Pharmacotherapy
Published: Jan 2011
58 citations
3985 days before retraction
Reversal effect of intra-central amygdala microinjection of L-arginine on place aversion induced by naloxone in morphine conditioned rats.
Sara Karimi, Manizheh Karami, Hedayat Sahraei et al. (4 authors)
PubMed
Published: Jan 2011
8 citations
4006 days before retraction
CAN REPEATED EXPOSURE TO MORPHINE CHANGE THE SPINAL ANALGESIC EFFECTS OF LIDOCAINE IN RATS? (SHORT COMMUNICATION)
Ali Dabbagh, Farkhondehkish Moghadam Shervin, Samira Rajaei et al. (5 authors)
Unknown Journal
Published: Jan 2011
2 citations
4006 days before retraction
Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases
Michelle L. Halls, Dermot M.F. Cooper
Cold Spring Harbor Perspectives in Biology Open Access
Published: Dec 2010
204 citations
4037 days before retraction
PTI-609: A Novel Analgesic that Binds Filamin A to Control Opioid Signaling
Lindsay H. Burns, Hoau-Yan Wang
Recent Patents on CNS Drug Discovery
Published: Nov 2010
23 citations
4067 days before retraction
The Interaction Between the Mu Opioid Receptor and Filamin A
Eric J. Simon, Irma Onoprishvili
Neurochemical Research
Published: Sep 2010
9 citations
4109 days before retraction
Clinical Pharmacology of Addicting Drugs
Jiang Liu, Hartmut Derendorf
Unknown Journal
Published: Jul 2010
4165 days before retraction
An Ultra-Low Dose of Naloxone Added to Lidocaine or Lidocaine-Fentanyl Mixture Prolongs Axillary Brachial Plexus Blockade
NULL AUTHOR_ID
Survey of Anesthesiology
Published: May 2010
4 citations
4225 days before retraction
Co-administration of ultra-low dose naloxone attenuates morphine tolerance in rats via attenuation of NMDA receptor neurotransmission and suppression of neuroinflammation in the spinal cords
Shinn‐Long Lin, Ru‐Yin Tsai, Ching‐Hui Shen et al. (7 authors)
Pharmacology Biochemistry and Behavior
Published: May 2010
37 citations
4234 days before retraction
How to design an opioid drug that causes reduced tolerance and dependence
Amy Berger, Jennifer L. Whistler
Annals of Neurology Open Access
Published: Apr 2010
67 citations
4256 days before retraction
Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone
D. Andrew Tompkins, Ryan K. Lanier, Joseph A. Harrison et al. (5 authors)
Psychopharmacology Open Access
Published: Apr 2010
28 citations
4270 days before retraction
Modulation by Neuropeptide FF of the interaction of Mu-opioid (MOP) receptor with G-proteins
Flavie Kersanté, Lionel Moulédous, Jean‐Marie Zajac et al. (4 authors)
Neurochemistry International
Published: Mar 2010
9 citations
4304 days before retraction
Gabapentin improves cold-pressor pain responses in methadone-maintained patients
Peggy Compton, Priscilla Kehoe, Karabi Sinha et al. (5 authors)
Drug and Alcohol Dependence Open Access
Published: Feb 2010
76 citations
4319 days before retraction
Opioid-induced hyperalgesia: a clinical challenge
Lesley Colvin, Marie Fallon
British Journal of Anaesthesia Open Access
Published: Jan 2010
73 citations
4353 days before retraction
No hyperalgesia following opioid withdrawal after the oripavine derivative etorphine compared to remifentanil and sufentanil
Enno Freye, Joseph V. Levy
European Journal of Anaesthesiology Open Access
Published: Jan 2010
9 citations
4361 days before retraction
Ultra-Low-Dose Naloxone or Naltrexone to Improve Opioid Analgesia: The History, the Mystery and a Novel Approach
Lindsay H. Burns, Hoau-Yan Wang
Clinical Medicine Insights Therapeutics Open Access
Published: Jan 2010
22 citations
4371 days before retraction
NEUROKININ 1 RECEPTORS AND THEIR ROLE IN OPIOID-INDUCED HYPERALGESIA, ANTINOCICEPTIVE TOLERANCE AND REWARD
Tally M. Largent‐Milnes
Unknown Journal
Published: Jan 2010
1 citation
4371 days before retraction
Pain and Addiction
Lynda Wells
Springer eBooks
Published: Jan 2010
1 citation
4371 days before retraction
A Novel Alternatively Spliced Isoform of the Mu-Opioid Receptor: Functional Antagonism
Pavel Gris, Josée Gauthier, Philip J. Cheng et al. (11 authors)
Molecular Pain Open Access
Published: Jan 2010
60 citations
4371 days before retraction
Stability of heroin metabolites and oxycodone in rat hair and liver during decomposition
Galiena W. Tse
Unknown Journal
Published: Jan 2010
4371 days before retraction
Ultra-Low Dose Naltrexone Attenuates Chronic Morphine-Induced Gliosis in Rats
Theresa-Alexandra M Mattioli, Brian Milne, Catherine M. Cahill
Molecular Pain Open Access
Published: Jan 2010
54 citations
4371 days before retraction
Peripheral antinociceptive effects of low doses of naloxone in an in vivo and in vitro model of trigeminal nociception
Alessandro Capuano, Alice De Corato, Mariangela Treglia et al. (7 authors)
Neuropharmacology
Published: Dec 2009
12 citations
4374 days before retraction
Challenging Clinical Issues on the Interaction Between Addiction and Hyperalgesia
Walter Ling, Peggy Compton
CRC Press eBooks
Published: Oct 2009
3 citations
4438 days before retraction
An Ultra-Low Dose of Naloxone Added to Lidocaine or Lidocaine-Fentanyl Mixture Prolongs Axillary Brachial Plexus Blockade
Ali Movafegh, Behrang Nouralishahi, Mustafa Sadeghi et al. (4 authors)
Anesthesia & Analgesia Open Access
Published: Oct 2009
27 citations
4449 days before retraction
The Growing Challenge
Unknown Authors
Harvard University Press eBooks
Published: Aug 2009
11 citations
4494 days before retraction
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of μ-opioid receptors from Gs-protein to coupling to Gi-protein
R.-Y. Tsai, Yueh-Hua Tai, J I Tzeng et al. (6 authors)
Neuroscience
Published: Aug 2009
45 citations
4512 days before retraction
Supraspinal Gβγ‐dependent stimulation of PLCβ<sub>3</sub> originating from G inhibitory protein‐μ opioid receptor‐coupling is necessary for morphine induced acute hyperalgesia
Enrica Bianchi, Monica Norcini, Alan V. Smrcka et al. (4 authors)
Journal of Neurochemistry Open Access
Published: Jul 2009
41 citations
4529 days before retraction
Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal
Ruth Drdla-Schutting, Matthias Gassner, Ewald Gingl et al. (4 authors)
Science
Published: Jul 2009
209 citations
4547 days before retraction
Molecular, Anatomical, Physiological, and Behavioral Studies of Rats Treated with Buprenorphine after Spinal Cord Injury
José M. Santiago, Odrick R. Rosas, Aranza I. Torrado et al. (6 authors)
Journal of Neurotrauma Open Access
Published: Jun 2009
34 citations
4560 days before retraction
Early Outcomes Following Low Dose Naltrexone Enhancement of Opioid Detoxification
Paolo Mannelli, Ashwin A. Patkar, Kathleen Peindl et al. (6 authors)
American Journal on Addictions Open Access
Published: Mar 2009
22 citations
4674 days before retraction
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin–treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway
R.-Y. Tsai, Yueh-Hua Tai, J I Tzeng et al. (9 authors)
Neuroscience
Published: Feb 2009
31 citations
4702 days before retraction
Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor–Gs Coupling and CREB Activation of Acute Morphine
Hoau-Yan Wang, Lindsay H. Burns
PLoS ONE Open Access
Published: Jan 2009
63 citations
4711 days before retraction
Ultra-Low-Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids
Lindsay H. Burns, Francesco Leri, Mary C. Olmstead
Humana Press eBooks
Published: Jan 2009
2 citations
4736 days before retraction
Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance
Lindsay H. Burns, Todd W. Vanderah, Hoau-Yan Wang
Humana Press eBooks
Published: Jan 2009
2 citations
4736 days before retraction
THE PHARMACOLOGY OF OXYCODONE, Studies In Vitro, In Vivo and in Humans
Kim K. Lemberg
Unknown Journal
Published: Dec 2008
4756 days before retraction
Tolerance to the anticonvulsant effect of morphine in mice: Blockage by ultra-low dose naltrexone
Maryam Roshanpour, Mehdi Ghasemi, Kiarash Riazi et al. (6 authors)
Epilepsy Research
Published: Dec 2008
27 citations
4761 days before retraction
Membrane signalling complexes: Implications for development of functionally selective ligands modulating heptahelical receptor signalling
Graciela Piñeyro
Cellular Signalling
Published: Sep 2008
29 citations
4852 days before retraction
CLINICAL STUDY: Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial
Paolo Mannelli, Ashwin A. Patkar, Kathi Peindl et al. (6 authors)
Addiction Biology Open Access
Published: Aug 2008
42 citations
4871 days before retraction
Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone
Stanley M. Crain, Ke-Fei Shen
Brain Research
Published: Jul 2008
13 citations
4908 days before retraction
Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, tolerance, and withdrawal
Nobue Kitanaka, Junichi Kitanaka, F. Scott Hall et al. (8 authors)
Synapse Open Access
Published: Jun 2008
19 citations
4927 days before retraction
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice
Arash Bahremand, Hamed Shafaroodi, Mehdi Ghasemi et al. (6 authors)
Epilepsy Research
Published: May 2008
38 citations
4953 days before retraction
Oxycodone Plus Ultra-Low-Dose Naltrexone Attenuates Neuropathic Pain and Associated μ-Opioid Receptor–Gs Coupling
Tally M. Largent‐Milnes, Wenhong Guo, Hoau-Yan Wang et al. (5 authors)
Journal of Pain Open Access
Published: May 2008
69 citations
4969 days before retraction
Co-administration of opioid agonists and antagonists in addiction and pain medicine
Francesco Leri
Expert Opinion on Pharmacotherapy
Published: May 2008
9 citations
4970 days before retraction
Cocaine exposure during the early postnatal period diminishes medial frontal cortex Gs coupling to dopamine D1-like receptors in adult rat
N. Zhao, Hoau-Yan Wang, Diana Dow-Edwards
Neuroscience Letters Open Access
Published: Apr 2008
8 citations
5001 days before retraction
Use of Potent Opioids for Chronic Pain Management
Enno Freye, Joseph V. Levy
Springer eBooks
Published: Mar 2008
5032 days before retraction
Supersensitivity to μ-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Gα protein subunits
Ricardo Mostany, Álvaro Díaz, Elsa M. Valdizán et al. (6 authors)
Neuropharmacology
Published: Feb 2008
12 citations
5052 days before retraction
Quick Stats
Total Citations: 172
Years Since Retraction: 3.9 years
Open Access: Yes
Last Checked: Jul 24, 2025
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